Inhibition of Solid Tumor Formation by Prior Immunization with Formalized Neoplastic Spleen Extracts.

Induction of Immunity in Mice with Tissue Culture Cells Chronically Infected with Rauscher Murine Leukemia Virus

“…On the other hand, Tyndall et al (15) reported that such protection can be induced by immunizing mice with formalized neoplastic spleen extracts. On the other hand, Tyndall et al (15) reported that such protection can be induced by immunizing mice with formalized neoplastic spleen extracts.…”

“…Barski and Youn (13) reported on the immunity of mice to Rauscher mouse leukemia virus (RMLV) following injection of tissue culture virus combined with ruptured cells chronically infected with RMLV, or by the injection of live intact virus infected cells (14). Tyndall et al (15) have shown recently that offspring of mice inoculated during pregnancy with RMLV vaccine prepared from infected spleen extract became resistant to challenge with RMLV induced tumor cells.…”

Immunization against primary, transplanted and spontaneous murine leukaemia using a live Moloney sarcoma virus vaccine

“…However, on different occasions, active immunization methods have been used, such as: (1) syngeneic transplantable leukaemia in sub-threshold doses (Axelrad, 1963;Klein & Klein, 1964;Pasternak & Graffi, 1963); (2) allogeneic transplantable leukaemia (Klein & Klein, 1964;McCoy et al, 1967;Pasternak & Graffi, 1963); (3) culture cells chronically infected with virus (Barski & Youn, 1965;Mayyasi et al, 1968); (4) infectious leukaemia virus (Bianco et al, 1966;Glynn et al, 1964Glynn et al, , 1968Klein & Klein, 1964;Mayyasi & Moloney, 1967;McCoy et al, 1967;Sachs, 1962;Slettenmark & Klein, 1962); (5) attenuated leukaemia virus (Fink & Rauscher, 1964;Friend, 1959;Huebner et al, 1976;Kelloff et al, 1976;Mayyasi & Moloney, 1967;McCoy et al, 1967;Tyndall, et al, 1967); (6) infectious murine sarcoma virus Huebner et al, 1976;Basombrio et al, 1977); and (7) purified viral components (Hunsmann et al, 1975;Ihle et al, 1976a,b). The variability among experimental protocols makes a direct comparison of the different results extremely difficult.…”