Inhibition of Shigella sonnei adherence to HT-29 cells by lactobacilli from Chinese fermented food and preliminary characterization of S-layer protein involvement

Lactobacillus plantarum isolated from kefir: Protection of cultured Hep-2 cells against Shigella invasion

“…Willer, Lima, and Giugliano (2004) demonstrated that the anti-invasive effects are mediated by the binding of glycoproteins to Shigella surface proteins, thus implying that functional proteins expressed on the bacterium's surface may possibly constitute a specific target on Shigella. Certain lactobacilli have a proteinaceous layer on their surface referred to as the S layer; this structure has accordingly been associated with the protection against adhesion and invasion of Shigella and other pathogens (Golowczyc et al, 2007;Zhang et al 2010). The results presented here, however, demonstrate that the inhibition of Shigella invasion by Lb.…”

Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX

“…This capability has been attributed to the production of antibacterial factors, such as bacteriocins or organic acids (Kaewnopparat et al, 2013;Satish-Kumar et al, 2011), as well as to the presence of specific structural components in the surface of the lactobacilli. It has been indicated that these components are cell surface associated proteins (Varma, Dinesh, Menon, & Biswas, 2010) or Slayer macromolecules built from proteins (Zhang et al, 2010). The putative mechanisms behind the reduction of pathogen attachment to IEC are a steric hindrance of lactobacilli avoiding the interaction of the pathogen (Satish-Kumar et al, 2011) and also co-aggregation phenomena (Kaewnopparat et al, 2013).…”

Epidemiology and molecular mechanism of integron-mediated antibiotic resistance in Shigella

“…The four Shigella species, Shigella boydii, Shigella dysenteriae, Shigella flexneri, and Shigella sonnei, are responsible for gastroenteritis that may progress to mucoid bloody diarrhea, also known as dysentery (Mead et al 1999;Saeed et al 2009;Zhang et al 2010). Each year, 1.1 million people are estimated to die from Shigella infection globally and nearly 580,000 cases of shigellosis are reported among travelers from industrialized countries (Kotloff et al 1999).…”