Inhibition of radical-induced oxidative DNA damage by antioxidants loaded in electrospun polylactide nanofibers

Growth of epithelial cells on films of enzymatically synthesized poly(gallic acid) crosslinked to carboxymethylcellulose

“…water-soluble forms of vitamin B6 (pyridoxine, pyridoxal and pyridoxamine), and small polyphenols such as coumaric and caffeic acids. 14,15 Nonetheless, the characteristics in most of the natural polyphenol extracts, specially their low molecular stability against temperature or UV-irradiation, as well as high hydrophobicity or their limited extractions in large quantities restricts their bioavailability and processability; thereby their modications play an important role to produce synthetic derivatives with adequate characteristics and scale-up feasibility. 16 Enzyme-mediated modications offer environmentally favourable and mild process conditions that resulted in non-toxic products.…”

Multifunctional ternary drug‐loaded electrospun scaffolds

“…PLA is a semicrystalline polymer that exhibits polymorphism, with different crystalline arrangements dependent on the crystallization conditions having been described . Usually, the polymer crystallizes in a 10 7 helical conformation that gives rise to the so‐called α‐, α′,‐ and α″‐ forms and the ε‐crystals when the polymer is complexed with solvents like dimethylformamide.…”

“…PLA is a semicrystalline polymer that exhibits polymorphism, with different crystalline arrangements dependent on the crystallization conditions having been described. 30,35 Usually, the polymer crystallizes in a 10 7 helical conformation that gives rise to the so-called a-, 66-68 a 0 ,- 69 and a 00 -70 forms and the e-crystals 71 when the polymer is complexed with solvents like dimethylformamide. Furthermore, PLA can adopt a 3 2 molecular conformation as reported for b 72,73 and c 74 structures prepared by stretching or epitaxial crystallization.…”

“…Thus, TCS has been extensively used for topical applications, and its controlled release from biomaterials evaluated . CUM is an hydroxycinnamic acid with a recognized activity as scavenger for the prevention of the oxidative stress damage produced by free radicals . KTP is a nonsteroidal anti‐inflammatory drug (NSAID) used to control pain and inflammation in rheumatic diseases, being also effective as an anti‐inflammatory agent in humans with flogistic diseases …”

“…30,34 CUM is an hydroxycinnamic acid with a recognized activity as scavenger for the prevention of the oxidative stress damage produced by free radicals. 35,36 KTP is a nonsteroidal anti-inflammatory drug (NSAID) used to control pain and inflammation in rheumatic diseases, being also effective as an anti-inflammatory agent in humans with flogistic diseases. 37,38 The goal of this work is the preparation of multiactive electrospun scaffolds that could represent an improved material for the regeneration and repair of a damaged tissue.…”