Inhibition of Pregnancy in the Passively and Actively Immunized Mammals Rabbit, Rat, and Mouse

Buscaglia, Marino; Ong, Michael; Fuller, John Randolph; González, Ana-Maria; Baird, Andrew

doi:10.1111/j.1749-6632.1991.tb49080.x

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…Sustained presence of both FGF-2 and its receptor 1 protein in these cells seems to be essential to initiate and maintain the renewal and growth of endometrial vasculature for successful implantation and conceptus nourishment. In addition to that, the pivotal role of this ligand receptor system in angiogenic and nonangiogenic events in porcine endometrium is brought out by the fact that immunization of rodents with FGF-2 resulted in failure of pregnancy [49].…”

Section: Discussionmentioning

confidence: 99%

Developmental and hormonal regulated gene expression of fibroblast growth factor 2 (FGF-2) and its receptors in porcine endometrium

Welter

Wollenhaupt

Einspanier

2004

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 99%

Developmental and hormonal regulated gene expression of fibroblast growth factor 2 (FGF-2) and its receptors in porcine endometrium

Welter

Wollenhaupt

Einspanier

2004

The Journal of Steroid Biochemistry and Molecular Biology

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“…However, pregnancy is inhibited in rodents immunized against FGF2 [103]. FGFR-1 protein expression is markedly reduced in women with menorrhagia compared to normal cycling women [104].…”

Section: Fgf2 (Bfgf)mentioning

confidence: 99%

Angiogenesis in implantation

Torry

Leavenworth

Chang

et al. 2007

J Assist Reprod Genet

148

109

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VEGF, bFGF, and their receptors in the endometrium of rhesus monkey during menstrual cycle and early pregnancy

Wei

Chen

Song

et al. 2004

Molecular Reproduction Devel

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A number of cytokines and growth factors are known to modulate proliferation and differentiation of human endometrium. In this study, the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and VEGF receptors, fms-like tyrosine kinase (Flt1) and kinase insert domain-containing region (KDR), and bFGF receptor 1 (Flg) were examined in the endometrium of rhesus monkey on Day 5, 10, 16, 20, 25 of menstrual cycle and on Day 19 of early pregnancy. Western blot analysis showed the specificity of the anti-human antibodies with the monkey tissue. The expression of mRNA and protein of VEGF was correlated with that of its receptor KDR, which was detected in epithelial, vascular, and myometrial cells. The localization of bFGF and its receptor Flg was similar to that of VEGF, except that the Flg was absent in the endothelial cells. Strong expression of VEGF and bFGF in the glandular epithelial cells was observed in the proliferative phase, declined in the secretory phase during the cycle. Stronger staining of these factors was also observed in the decidual cells of the pregnant uterus, as compared with the stromal cells of cycling uterus. No expression of Flt1 was detected in the tissue examined in this study. These data suggest that VEGF, bFGF, and their receptors play important roles in epithelial and stromal development, angiogenesis, and blood vessel function in the endometrium during the menstrual cycle and early pregnancy of the rhesus monkey.

show abstract

Inhibition of Pregnancy in the Passively and Actively Immunized Mammals Rabbit, Rat, and Mouse

Cited by 3 publications

References 1 publication

Developmental and hormonal regulated gene expression of fibroblast growth factor 2 (FGF-2) and its receptors in porcine endometrium

Developmental and hormonal regulated gene expression of fibroblast growth factor 2 (FGF-2) and its receptors in porcine endometrium

Angiogenesis in implantation

VEGF, bFGF, and their receptors in the endometrium of rhesus monkey during menstrual cycle and early pregnancy

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