Inhibition of pregnancy-associated granulocytic myeloid-derived suppressor cell expansion and arginase-1 production in preeclampsia

Wang, Yinan; Liu, Yanhou; Shu, Chen; Wan, Jiya; Shan, Yanhong; Zhi, Xinyi; Sun, Liguang; Yi, Huanfa; Yang, Yong‐Guang; He, Junqi

doi:10.1016/j.jri.2018.05.002

Cited by 30 publications

(19 citation statements)

References 40 publications

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“…In addition to the cells mentioned above, other recently identified immune cells, such as T follicular helper cells (Tfh), Th9, Th22, and myeloid-derived suppressor cells (MDSCs), also might be involved in PCOS. Tfh are increased in both recurrent spontaneous abortion [105] and preeclampsia patients [106] as compared with healthy pregnant women, whereas MDSCs decreased [107,108]; however, the interplay and relative changes that ultimately redirect and conduct PCOS are still unclear. Further research is warranted to elucidate the relationship between PCOS and immune cells.…”

Section: Other Immunological Mechanisms Of Pcosmentioning

confidence: 99%

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Pang

et al. 2020

Mediators of Inflammation

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Polycystic ovary syndrome (PCOS) a long-known endocrinopathy and one of the most common endocrine-reproductivemetabolic disorders in women, which can lead to infertility. Although the precise etiology remains unclear, PCOS is considered as a complex genetic trait, with a high degree of heterogeneity. Besides, hormones and immune cells, including both innate and adaptive immune cells, are reportedly a cross talk in PCOS. Chronic low-grade inflammation increases autoimmune disease risk. This proinflammatory condition may, in turn, affect vital physiological processes that ultimately cause infertility, such as ovulation failure and embryo implantation. Here, we review the accumulating evidence linking PCOS with inflammatory status providing an overview of the underlying hormone-mediated dysregulation of immune cells. We mainly focus on the correlational evidence of associations between immune status in women and the increased prevalence of PCOS, along with the specific changes in immune responses. Further recognition and exploration of these interactions may help elucidate PCOS pathophysiology and highlight targets for its treatment and prevention.

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Section: Other Immunological Mechanisms Of Pcosmentioning

confidence: 99%

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Pang

et al. 2020

Mediators of Inflammation

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“…In another recent study, G-MDSCs were downregulated in IVF failures patients as well ( 96 ). A very recent literature showed pregnancy associated G-MDSCs and effector molecule Arg-I is significantly inhibited in pre-eclampsia patients with no difference in the population of Treg cells ( 97 ).…”

Section: Yin and Yang Arms Of Mdscsmentioning

confidence: 99%

The Yin and Yang of Myeloid Derived Suppressor Cells

Budhwar

Verma

et al. 2018

Front. Immunol.

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In recent years, most of our knowledge about myeloid derived suppressor cells (MDSCs) has come from cancer studies, which depicts Yin side of MDSCs. In cancer, inherent immunosuppressive action of MDSCs favors tumor progression by inhibiting antitumor immune response. However, recently Yang side of MDSCs has also been worked out and suggests the role in maintenance of homeostasis during non-cancer situations like pregnancy, obesity, diabetes, and autoimmune disorders. Continued work in this area has armored the biological importance of these cells as master regulators of immune system and prompted scientists all over the world to look from a different perspective. Therefore, explicating Yin and Yang arms of MDSCs is obligatory to use it as a double edged sword in a much smarter way. This review is an attempt toward presenting a synergistic coalition of all the facts and controversies that exist in understanding MDSCs, bring them on the same platform and approach their “Yin and Yang” nature in a more comprehensive and coherent manner.

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“…ARG1 is an important effector molecule for granulocytic myeloid-derived suppressor cells (G-MDSCs) which maintain maternal-fetal tolerance during pregnancy. ARG1 has found to be reduced in PE patients compared to healthy pregnant women resulting in inhibition of the development of G-MDSCs 37 . Additionally, one characteristic of hypertension, a major feature of PE, is a decreased endothelium-dependent nitric oxide (NO)-mediated vasodilation.…”

Section: Discussionmentioning

confidence: 97%

Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta

Yadama

Maiorino

Carey

et al. 2020

Sci Rep

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Several studies have linked maternal asthma, excess BMI, and low vitamin D status with increased risk of Preeclampsia (PE) development. Given prior evidence in the literature and our observations from the subjects in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we hypothesized that PE, maternal asthma, vitamin D insufficiency, and excess body mass index (BMI) might share both peripheral blood and placental gene signatures that link these conditions together. We used samples collected in the VDAART to investigate relationships between these four conditions and gene expression patterns in peripheral blood obtained at early pregnancy. We identified a core set of differentially expressed genes in all comparisons between women with and without these four conditions and confirmed them in two separate sets of samples. We confirmed the differential expression of the shared gene signatures in the placenta from an independent study of preeclampsia cases and controls and constructed the preeclampsia module using protein–protein interaction networks. CXC chemokine genes showed the highest degrees of connectivity and betweenness centrality in the peripheral blood and placental modules. The shared gene signatures demonstrate the biological pathways involved in preeclampsia at the pre-clinical stage and may be used for the prediction of preeclampsia.

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Inhibition of pregnancy-associated granulocytic myeloid-derived suppressor cell expansion and arginase-1 production in preeclampsia

Cited by 30 publications

References 40 publications

Immunophenotypic Profiles in Polycystic Ovary Syndrome

Immunophenotypic Profiles in Polycystic Ovary Syndrome

The Yin and Yang of Myeloid Derived Suppressor Cells

Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta

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