Inhibition of porcine detrusor contractility by the flavonoid fraction of Bryophyllum pinnatum – a potential phytotherapeutic drug for the treatment of the overactive bladder syndrome

Fürer, Karin; Eberli, Daniel; Betschart, Cornelia; Brenneisen, Rudolf; Mieri, Maria De; Hamburger, Matthias; Eiff, M. Mennet-von; Potterat, Olivier; Martin, Sebastian; Simões-Wüst, Ana Paula; Mandach, Ursula von

doi:10.1016/j.phymed.2014.11.009

Cited by 19 publications

(20 citation statements)

References 21 publications

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“…Several retrospective and a few prospective studies on the treatment of preterm contractions and of overactive bladder with BP preparations have been performed and suggest good effectiveness and very good safety/tolerability. The data are in line with the relaxant effects of BP preparations that have been observed in in vitro models, admittedly on smooth muscle, myometrium, or detrusor . Prospective observational studies have also revealed positive effects on sleep quality, both during pregnancy and among cancer patients .…”

Section: Discussionsupporting

confidence: 82%

Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

Manitius

Flügel

Steinlein

et al. 2019

Clinical Case Reports

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Key Clinical Message Restless legs syndrome may seriously affect patients' sleep and quality of life, but established pharmacological therapy can often have severe side effects. Therefore, new therapeutic approaches such as well‐tolerated preparations from the medicinal plant Bryophyllum pinnatum should be considered as alternatives. Their sedative and spasmolytic properties might contribute to improve patients' condition.

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Section: Discussionsupporting

confidence: 82%

Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

Manitius

Flügel

Steinlein

et al. 2019

Clinical Case Reports

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“…An unexpected inhibitory effect was found in the polar fraction that contained substances that were not retained on a HP-20 column. Finally, this effect could be explained by a decreased pH in the organ bath chamber due to the presence of a large amount (17.8 %) of L-malic acid in this fraction [76].…”

Section: Overactive Bladder (Oab) Syndromementioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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“…In contrast, the bufadienolide-containing lipophilic fraction had no inhibitory effect on contractility at the concentrations used in the study. However, due to poor solubility the test concentrations were significantly lower than for the flavonoid-containing fraction [44].…”

Section: Bryophyllum Pinnatummentioning

confidence: 87%

Bryophyllum pinnatum – Reverse Engineering of an Anthroposophic Herbal Medicine

Hamburger

Potterat

Fürer

et al. 2017

Natural Product Communications

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Bryophyllum pinnatum (syn. Kalanchoe pinnata), a plant native to Madagascar, was introduced into anthroposophic medicine in the early 20 th century. In recent years, a number of investigations were conducted on the chemical composition, pharmacological properties, and clinical efficacy of Bryophyllum. Here the phytochemistry, and pharmacological and clinical data are reviewed. With respect to pharmacology, a special focus was put on properties related to the use in anthroposophic medicine as a treatment for "hyperactivity diseases", including preterm labor, restlessness, and sleep disorders. Recent studies suggest that B. pinnatum has also potential as a treatment option in patients suffering from overactive bladder syndrome. Tolerability of Bryophyllum is addressed, and existing toxicological data are discussed in relation to bufadienolides contained in Bryophyllum. Open questions regarding the use of Bryophyllum are also discussed.

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Inhibition of porcine detrusor contractility by the flavonoid fraction of Bryophyllum pinnatum – a potential phytotherapeutic drug for the treatment of the overactive bladder syndrome

Cited by 19 publications

References 21 publications

Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum – Reverse Engineering of an Anthroposophic Herbal Medicine

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