Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs

Morita, Mayuko; Naito, Yuji; Yoshikawa, Toshikazu; Niki, Etsuo

doi:10.1016/j.bmcl.2016.10.033

Cited by 6 publications

(2 citation statements)

References 57 publications

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“…Edaravone can scavenge 1 O 2 that is generated by activated human neutrophils [ 66 ] and by photoactivated Rose Bengal [ 67 ]. The plasma lipid peroxidation caused by 1 O 2 , however, cannot be suppressed by edaravone and other clinical drugs with antioxidant ability, which include roglitazone, probucol, carvedilol, pentoxifylline and ebselen, although they exhibit suppressive effects on lipid peroxidation caused by free radicals, peroxynitrite, hypochlorite, and lipoxygenase reactions [ 68 ]. Because blood plasma contains high concentrations of proteins and many other compounds that could potentially interfere with the scavenging reaction by these chemicals, such biological compounds may have influenced the results.…”

Section: Fundamental Knowledge Of the Biochemical Properties Of ...mentioning

confidence: 99%

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

2023

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Energy transfer to ground state triplet molecular oxygen results in the generation of singlet molecular oxygen (1O2), which has potent oxidizing ability. Irradiation of light, notably ultraviolet A, to a photosensitizing molecule results in the generation of 1O2, which is thought to play a role in causing skin damage and aging. It should also be noted that 1O2 is a dominant tumoricidal component that is generated during the photodynamic therapy (PDT). While type II photodynamic action generates not only 1O2 but also other reactive species, endoperoxides release pure 1O2 upon mild exposure to heat and, hence, are considered to be beneficial compounds for research purposes. Concerning target molecules, 1O2 preferentially reacts with unsaturated fatty acids to produce lipid peroxidation. Enzymes that contain a reactive cysteine group at the catalytic center are vulnerable to 1O2 exposure. Guanine base in nucleic acids is also susceptible to oxidative modification, and cells carrying DNA with oxidized guanine units may experience mutations. Since 1O2 is produced in various physiological reactions in addition to photodynamic reactions, overcoming technical challenges related to its detection and methods used for its generation would allow its potential functions in biological systems to be better understood.

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Section: Fundamental Knowledge Of the Biochemical Properties Of ...mentioning

confidence: 99%

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

2023

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“…Hydroperoxides can generate alkoxy radical RO upon the breaking of their oxygen–oxygen bonds or other compounds such as aldehydes, acids and hydrocarbons upon the breaking of their carbon–carbon bonds. In addition, RO can also be decomposed into ketones, alcohols and aldehydes, such as the secondary oxidation products malondialdehyde (MDA), α, β-unsaturated aldehyde and hexanal [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Peroxyl Radicals on the Structural Characteristics and Fatty Acid Composition of High-Density Lipoprotein from Duck Egg Yolk

Jing

Zeng

Yang

et al. 2022

Foods

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In this study, high-density lipoprotein (HDL) from duck egg yolk was subjected to oxidation with a system based on 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH)-derived peroxyl radicals. The effects of peroxyl radicals on the protein carbonyl, free sulfhydryl, secondary/tertiary structure, surface hydrophobicity, solubility, particle size distribution, zeta potential and fatty acid composition of HDL were investigated by using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), Fourier-transform infrared spectroscopy (FTIR), circular dichroism (CD), fluorescence spectroscopy, dynamic light scattering and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). The results indicated that the content of protein carbonyl was significantly increased, that of free sulfhydryl was obviously reduced, and the ordered secondary structure was also decreased with increasing AAPH concentration. In addition, the surface hydrophobicity and solubility of HDL showed apparent increases due to the exposure of hydrophobic groups and aggregation of protein caused by oxidation. The fatty acid composition of HDL exhibited pronounced changes due to the disrupted protein–lipid interaction and lipid oxidation by AAPH-derived peroxyl radicals. These results may help to elucidate the molecular mechanism for the effect of lipid oxidation products on the oxidation of duck yolk proteins.

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Isomer distribution of hydroxyoctadecadienoates (HODE) and hydroxyeicosatetraenoates (HETE) produced in the plasma oxidation mediated by peroxyl radical, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen

Umeno

Morita

Yoshida

et al. 2017

Archives of Biochemistry and Biophysics

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Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs

Cited by 6 publications

References 57 publications

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death

Effects of Peroxyl Radicals on the Structural Characteristics and Fatty Acid Composition of High-Density Lipoprotein from Duck Egg Yolk

Isomer distribution of hydroxyoctadecadienoates (HODE) and hydroxyeicosatetraenoates (HETE) produced in the plasma oxidation mediated by peroxyl radical, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen

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