Inhibition of Plaque Formation and Gingivitis in Beagle Dogs by Topical Use of a Degradable Controlled-release System Containing Chlorhexidine

Abstract

The in vivo efficacy of a newly-developed dental application of a film-forming, chlorhexidine-containing system was examined in beagle dogs. A self-disintegrating film-forming solution was applied three times weekly to the dentitions of 7 out of 13 dogs, which were fed a soft-food diet. Plaque accumulation (Plaque Index) and gingival inflammation (Gingival Index) were recorded at one, two, four, six, and eight weeks. The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation. It is concluded that the dental application of a film-forming system may be a preferable method of periodontal disease prophylaxis, and may enhance supragingival plaque control in areas of isolated periodontal problems associated with obvious local predisposing factors.

Modifications of hydrophobicity, in vitro adherence and cellular aggregation of Streptococcus mutans by Helichrysum italicum extract

“…It is possible, moreover, that oral micro‐organisms may be exposed to sub‐inhibitory levels over time following the use of a topically sustained‐release delivery system or following the adsorption of inhibitor to oral tissues or dental material (Southard et al. 1984; Kozlovsky et al. 1992; Toumba and Curzon 1993).…”

Interaction of Chlorhexidine With Smooth and Rough Types of Titanium Surfaces

“…This creates a reservoir of CHX that results in a bacteriostatic milieu in the mouth 17,32‐34 . However, in vivo and in vitro studies show that plaque inhibition is achieved by the antibacterial effect of the chlorhexidine bound to the tooth surface rather than the chlorhexidine desorbed from other oral surfaces 18,34‐38 . The interaction of CHX with hydroxyapatite, enamel, root dentin, and soft oral tissues 39‐42 is the basis of its antibacterial and antiplaque efficacy in a natural tooth surface environment.…”

Effects of Subinhibitory Concentrations of Chemical Agents on Hydrophobicity and in vitro Adherence of Streptococcus mutans and Streptococcus sanguis

“…Sanguinaria extract is incorporated in an oral rinse at a concentration of 0.03%, corresponding to 0.01% sanguinarine chloride. Therefore, it is possible that microorganisms in the mouth could be exposed to SC of antiseptics or fluorides over time following a regimen of rinsing or use of a topically sustained-release delivery sys tem [Kozlovsky et al, 1992;Toumba and Curzon, 1993]. In addition, it has been shown that chlorhexidine [Mandel, 1988;Addy et al, 1992] and sanguinarine [Southard et al.…”