Interaction of Chlorhexidine With Smooth and Rough Types of Titanium Surfaces

Kozlovsky, Avital; Artzi, Zvi; Moses, Ofer; Kamin-Belsky, Nurit; Greenstein, Ronit Bar-Ness

doi:10.1902/jop.2006.050401

Cited by 76 publications

(70 citation statements)

References 48 publications

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“…Studies have absorbed chlorhexidine to the TiO 2 layer on the titanium surface, but the gradual release period is only several days. 27 Silver has also been introduced into titania nanotubes to enhance the bactericidal ability, 28 nevertheless, its bactericidal mechanism needs further clarification. Thus, novel implant antibacterial-coating system is important.…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants

Cheng

Gao

Liu

et al. 2016

IJN

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To prevent peri-implant infection, a new antibacterial coating containing a halogenated furanone compound, ( Z -)-4-bromo-5-(bromomethylene)-2(5 H )-furanone-loaded poly( l -lactic acid) nanoparticles, has been fabricated. The current study was designed to evaluate the preventive effect of the antibacterial coating under a simulated environment of peri-implant infection in vivo. Microarc-oxidized titanium implants treated with minocycline hydrochloride ointment were used as positive control group, and microarc-oxidized titanium implants without any treatment were used as blank control group. Three kinds of implants were implanted in dogs’ mandibles, and the peri-implant infection was simulated by silk ligation and feeding high sugar diet. After 2-month implantation, the results showed that no significant differences were detected between the experimental and positive control groups ( P >0.05), but the data of clinical measurements of the blank control group were significantly higher than those of the other two groups ( P <0.05), and the bone–implant contact rate and ultimate interfacial strength were significantly lower than those of the other two groups ( P <0.05). Scanning electron microscope observation and histological examination showed that more new bone was formed on the surface of the experimental and positive control groups. It can be concluded that the antibacterial coating fabricated on implants has remarkable preventive effect on peri-implant infection at the early stage.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants

Cheng

Gao

Liu

et al. 2016

IJN

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“…The coated antibiotic-HA-composite exhibited a reduced infection rate compared with CaP coatings in vivo [105]. In order to reduce the risk of antibiotic resistance also non-antibiotic organic compounds with antimicrobial activity like chlorhexidine, chloroxylenol, and poly(hexamethylenebiguanide) [106][107][108][109][110][111][112] have been investigated as potential alternatives. These organic molecules are commonly used for their broad spectrum of antimicrobial action and lower risk of drug resistance.…”

Section: Trends In Materials For Composite and Combined Coatings On Bmentioning

confidence: 99%

Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

et al. 2012

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Abstract:The mechanical and biological properties of bone implants need to be optimal to form a quick and firm connection with the surrounding environment in load bearing applications. Bone is a connective tissue composed of an organic collagenous matrix, a fine dispersion of reinforcing inorganic (calcium phosphate) nanocrystals, and bone-forming and -degrading cells. These different components have a synergistic and hierarchical structure that renders bone tissue properties unique in terms of hardness, flexibility and regenerative capacity. Metallic and polymeric materials offer mechanical strength and/or resilience that are required to simulate bone tissue in load-bearing applications in terms of maximum load, bending and fatigue strength. Nevertheless, the interaction between devices and the surrounding tissue at the implant interface is essential for success or failure of implants. In that respect, coatings can be applied to facilitate the process of bone healing and obtain a continuous transition from living tissue to the synthetic implant. Compounds that are inspired by inorganic (e.g., hydroxyapatite crystals) or organic (e.g., collagen, extracellular matrix components, enzymes) components of bone tissue, are the most obvious candidates for application as implant coating to improve the performance of bone implants. This review provides an overview of recent trends and strategies in surface engineering that are currently investigated to improve the biological performance of bone implants in terms of functionality and biological efficacy. OPEN ACCESSCoatings 2012, 2 96

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“…16 The sterile discs were initially immersed in sterile saliva followed by immersion in each of the hygienic protocol solutions (Figure 1a). …”

Section: In Vitro Antibacterial Assaymentioning

confidence: 99%

“…Sterile aligner-material discs (N 5 60) (Cameo 25GAS, 0.45 pore size, Micron Separations, Inc. MSI, Westboro, MA) were placed in the filtered saliva and vortexed for 3 minutes and then dried at 37uC for 2 hours to enable adsorption of the different cleaning solutions. 16 CHX mouthwash. Sterilized saliva-coated aligner discs (N 5 25), were immersed in sterile CHX mouthwash (Lacer Co, Barcelona, Spain) for 15 minutes, washed in sterile distilled water at room temperature for 2 minutes, and dried at 37uC for 2 hours.…”

Section: Disc Immersion Protocolmentioning

confidence: 99%

“…Sterilized saliva-coated aligner discs (N 5 25), were immersed in sterile CHX mouthwash (Lacer Co, Barcelona, Spain) for 15 minutes, washed in sterile distilled water at room temperature for 2 minutes, and dried at 37uC for 2 hours. 16 For positive control, 10 mL of sterile CHX mouthwash was placed onto 5-mm discs of filter paper (N 5 5) following drying at 37uC for 2 hours.…”

Section: Disc Immersion Protocolmentioning

confidence: 99%

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Efficacy of three hygienic protocols in reducing biofilm adherence to removable thermoplastic appliance

Shpack

Greenstein

Gazit

et al. 2013

The Angle Orthodontist

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Objectives: To examine the ability of a removable thermoplastic appliance (RTA) to adsorb hygienic solutions and inhibit bacterial growth and to examine the efficacy of three hygiene protocols in reducing bacterial biofilm adherence to RTA. Materials and Methods: Solution adsorption and bacterial growth inhibition were examined in vitro using paper vs RTA discs. Subsequently, 11 patients treated with RTA (mean age, 29.1 6 4.7 years) were assigned into a sequence of three hygiene protocols: regular RTA brushing (baseline), immersion RTAs in chlorhexidine mouthwash (CHX), and using a vibrating bath with cleaning solution (VBC). For each patient, 12 upper RTAs were examined (2 baseline RTAs, 5 CHX RTAs, and 5 VBC RTAs), for a total of 132 RTAs. All RTAs were stained with gentian violet, and biofilm presence was measured using a photodensitometer. Results: The RTA discs did not adsorb CHX or cleaning solution. The later agent did not show antibacterial features. Baseline RTAs showed significant biofilm adherence (P , .001) on the posterior palatal side of the aligner and on the anterior incisal edge. CHX and VBC hygienic protocols significantly (P , .001) reduced baseline biofilm adherence by 16% and 50%, respectively. Hygienic improvement was maintained over 140 days when CHX and VBC were used. However, VBC was three times more efficient than CHX. Conclusions: This study highly recommends the use of a VBC protocol. Biofilm deposits on the RTA, especially on incisal edges and attachment dimples, could lead to inadequate tooth/RTA and attachment/RTA overlap and consequently impair tooth alignment. (Angle Orthod. 2014;84:161-170.)

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Interaction of Chlorhexidine With Smooth and Rough Types of Titanium Surfaces

Cited by 76 publications

References 48 publications

In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants

In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants

Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

Efficacy of three hygienic protocols in reducing biofilm adherence to removable thermoplastic appliance

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