Inhibition of orthotopic secondary hepatic carcinoma in mice by doxorubicin-loaded electrospun polylactide nanofibers

Antitumor activity of electrospun polylactide nanofibers loaded with 5-fluorouracil and oxaliplatin against colorectal cancer

“…In addition, electrospinning affords great flexibility in producing polymer fibers with customizable fiber size, porosity, drug loading rate and release mechanisms, leading to a possibility of tailoring the drug release rate for each application. Another advantage of drug-loaded electrospun fibers is their potential as implantable device intratumorally, adjacent to tumor, or at the surgical resection margins for cancer chemotherapy of solid tumors (Xu et al, 2009;Toshkova et al, 2010;Luo et al, 2012;Ignatova et al, 2013;Liu et al, 2013;Zamani et al, 2013, Zheng et al, 2013a.…”

Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy

“…Furthermore, the high porosity and interconnected porosity of nanofibers makes it easy for cell binding, thus reduced metastasis of cancer cells when used locally [10,11]. Various anticancer drugs, such as doxorubicin (DOX), paclitaxel (PTX) and dichloroacetate (DCA) have been successfully electrospun into fibers which showed enhanced anticancer efficacy [12][13][14]. However, a single cancer treatment method is commonly impossible to eliminate the tumor because of inefficient drug permeability in the tumor site and drug resistance of tumor cells, so the local treatment of malignant tumors using drug loaded electrospun nanofibers remains a great challenge [15][16][17].…”

Designed preparation of polyacrylic acid/calcium carbonate nanoparticles with high doxorubicin payload for liver cancer chemotherapy

“…S5 †) do not reveal any dysfunction in terms of the heart, liver, spleen, lung or kidney. 24 Based on the above discussion, we can conclude that PAA/CaCO 3 NPs possess great potential for application in cancer therapy as efficient drug carriers, which can effectively deliver anticancer drugs to restrain tumors in vivo with few side effects.…”