Inhibition of Neuroblastoma cancer cells viability by ferromagnetic Mn doped CeO2 monodisperse nanoparticles mediated through reactive oxygen species

Abbas, Fazal; Jan, Tariq; Iqbal, Javed; Naqvi, M. Sajjad H.; Ahmad, Ishaq

doi:10.1016/j.matchemphys.2016.01.042

Cited by 35 publications

(21 citation statements)

References 42 publications

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“…In order to achieve efficient drug development, it is vital to have the understanding of the toxicity of synthesized NS. Normally it has been observed that metal oxide NS show differential cytotoxicity when applied on healthy cells ( Abbas et al, 2016 ). In the current study, olive leaf extract mediated synthesis of NS demonstrates greater biocompatibility with the least lethal effect on Brine shrimps larvae as shown in Figure 9 .…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

et al. 2018

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One of the major challenges of nano-biotechnology is to engineer potent antimicrobial nanostructures (NS) with high biocompatibility. Keeping this in view, we have performed aqueous olive leaf extract mediated one pot facile synthesis of CuO-NS and CeO2-NS. Prepared NS were homogenous, less than 26 nm in size, and small crystallite units as revealed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses. Fourier transform infrared spectroscopy (FTIR) of CuO-NS and CeO2-NS showed typical Cu-O prints around 592–660 cm-1 and Ce-O bond vibrations at 453 cm-1. The successful capping of CuO-NS and CeO2-NS by compounds present in the plant extract was further validated by high performance liquid chromatography (HPLC) and thermal gravimetric analysis (TGA). Active phyto-chemicals from the leaf extract simultaneously acted as strong reducing as well as capping agent in the NS synthesis. NS engineered in the present study showed antibacterial potential at extremely low concentration against highly virulent multidrug-resistant (MDR) gram-negative strains (Escherichia coli, Enterobacter cloacae, Acinetobacter baumannii and Pseudomonas aeruginosa), alarmed by World Health Organization (WHO). Furthermore, CuO-NS and CeO2-NS did not show any cytotoxicity on HEK-293 cell lines and Brine shrimp larvae indicating that the NS green synthesized in the present study are biocompatible.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

et al. 2018

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“…It is a well-understood phenomenon that the SSA and crystallite size are inversely related. Hence, the enhancement in the SSA with the increase in the Mn doping concentration may be attributed to the decrease in the crystallite size [1, 22, 28]. The calculated ionic radii of Mn is 0.80 Å, which is less than the calculated ionic radii of Ce (1.01 Å) that caused the decrease in the crystallite size and lattice constant [12, 16]:1d2=h2+k2+l2a2.…”

Section: Resultsmentioning

confidence: 99%

“…Such a structural transformation may be due to the integration of Mn ions into the host CeO 2 matrix that occurs during chemical reactivity, as well in the lattice establishment of Mn as a dopant in CeO 2 . Thus, the lattice has an elevated proliferation towards a heterogeneous structure [13, 28].…”

Section: Resultsmentioning

confidence: 99%

“…However, differential toxicity occurs because a cell membrane is present along with the cell wall, which results in increased toxicity [19, 21, 31–39]. Many mechanisms have been discussed in relation to the action of nanocomposites towards bacteria [22, 28]. However, it is believed that the small size of the nanocomposites damages the cell wall when in contact, releasing cell/ions constituents by generating reactive oxygen species.…”

Section: Resultsmentioning

confidence: 99%

“…These factors may have affected the 7% activity during the experiment, such as the time lapse between the running of experiments, dissolution in the sample solution, aggregation in the solution, and time of incubation for internalizing the cellular environment. The reduced size of the CeO 2 nanocomposite doped with Mn (Mn x Ce 1− x O 2 at x = 1%) contributed to a higher contact surface area [28]. Despite this size, the results of different doping amounts showed different trends, which were most likely associated with a lower photocatalytic activity due to the high turbidity of the cultures resulting in reduced antibacterial activity.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity

Atif

Iqbal

Fakhar-e-Alam

et al. 2019

BioMed Research International

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In this experimental approach, we explored the structures, morphologies, phototoxicities, and antibacterial activities of undoped and Mn-doped ceria nanocomposite materials, MnxCe1−xO2. The MnxCe1−xO2 nanocomposites were synthesized by employing a soft chemical route. Our prime focus was on the influence of different factors, both physical and chemical, i.e., the concentration of manganese in the product, size of the nanocomposite, drug dose, and incubation time, on the bacterial strains. Different bacterial strains were selected as experimental biological models of the antibacterial activity of the manganese-doped cerium oxide nanocomposite. In addition to the photodynamic response, the adenocarcinoma cell line (MCF-7) was also studied. Based on cell viability losses and bacterial inhibition analyses, the precise mechanisms of apoptosis or necrosis of 5-ALA/PpIX-exposed MCF-7 cells under 630 nm red lights and under dark conditions were elucidated. It was observed that the undoped nanocomposites had lower cytotoxicities and inhibitions compared with those of the doped nanocomposites towards pathogens. The antibacterial activity and effectiveness for photodynamic therapy were enhanced in the presence of the manganese-doped ceria nanocomposite, which could be attributed to the correlation of the maximum reactive oxygen species generation for targeted toxicity and maximum antioxidant property in bacteria growth inhibition. The optimized cell viability dose and doping concentration will be beneficial for treating cancer and bacterial infections in the future.

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Hierarchical Assembly of Flexible Biopolymer Polyphosphate‐Manganese into Nanosheets

Wang

Tao

Juan

et al. 2022

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Polyphosphate (polyP) is one of the most compact inorganic polyanionic biopolymers that participates in various physiological processes. However, the development of polyP‐based nanomaterials is still in its infancy. Here, biocompatible polyphosphate‐manganese nanosheets are designed and synthesized by a hierarchical assembly strategy. The thickness and the lateral size of the resulting polyP‐Mn nanosheets (PMNSs) are 5 nm and 120–130 nm, respectively. Molecular dynamics simulations suggested that the polyP‐hexadecyl trimethyl ammonium bromide flat structure possesses a strong aggregating capacity and serves as the template for the 2D assembly of polyP‐Mn. The PMNSs can activate the inflammatory response of macrophages resulting in the recovery of innate immunological functions to inhibit tumor proliferation. This work has initiated a new direction in constructing layered polyP‐based nanomaterials and provides guidance for biocompatible and biodegradable biopolymer‐based materials in the regulation of innate responses.

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Inhibition of Neuroblastoma cancer cells viability by ferromagnetic Mn doped CeO2 monodisperse nanoparticles mediated through reactive oxygen species

Cited by 35 publications

References 42 publications

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity

Hierarchical Assembly of Flexible Biopolymer Polyphosphate‐Manganese into Nanosheets

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