Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity

Atif, M.; Iqbal, Seemab; Fakhar-e-Alam, M.; Ismail, Muhammad; Mansoor, Qaisar; Mughal, Lubna; Aziz, Muhammad Hammad; Hanif, Atif; Farooq, W. A.

doi:10.1155/2019/7156828

Cited by 49 publications

(18 citation statements)

References 37 publications

(76 reference statements)

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“…Many nanomedicine studies have stated that ZnO NPs could be used to develop antitumor agents due to their toxic nature. 34,35 The FSEderived ZnO NPs cytotoxicity results are in good agreement with those of previous studies. 36 Reactive oxygen species (ROS) are promoted by phytoconstituents activity.…”

Section: Results and Discussion Production And Characterization Of Znsupporting

confidence: 90%

<p>Therapeutic Potential Assessment of Green Synthesized Zinc Oxide Nanoparticles Derived from Fennel Seeds Extract</p>

AlSalhi¹,

Devanesan²,

Al-Qahtani³

et al. 2020

IJN

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To study the cytotoxic evaluation, antimicrobial and confocal analysis of zinc oxide nanoparticles (ZnO NPs) obtained from a novel plant product fennel (Foeniculum vulgare Mill.) seed extract (FSE). Methods: ZnO NPs were analyzed using UV-Vis spectroscopy, XRD, FTIR, TEM and EDX techniques. The MTT cell cytotoxicity assay measured the proliferation and survival of MCF-7 cells treated at different concentrations of FSE-derived ZnO NPs. The antimicrobial activity towards pathogenic bacteria and yeast strains was investigated. Results: The UV-Vis spectra showed two peaks at 438 nm and 446 nm, confirming nanoparticle formation. The SEM morphology results showed porous ranging from 23-51 nm. The antitumor activity value (IC 50) was at 50 µg/mL and 100 µg/mL. Besides, morphological changes of MCF-7, cells treated at different concentrations of FSE of ZnO NPs were observed in cell cultures transfected with a transient pCMV6-XL4-GFP-expressing vector containing C-terminal domain GFP-tagged proteins, which resulted in an apoptotic effect. Antimicrobial IZ ranged up No Inhibition to 18.00 ± 0.4. The IZ revealed at the highest concentration was E. faecium VRE and yeast Cryptococcus sp. (18.00 ± 0.4. mm), followed by S. aureus (17.00 ± 0.2 mm) and P. aeruginosa and the yeast C. parapsilosis (16 ± 0.4 mm). The IZ was equal to that caused by the nystatin to Cryptococcus sp., which was significantly highest than ampicillin treatments of S. aureus, P. aeruginosa, C. albicans, and C. parapsilosis. The MIC value of the FSE-derived ZnO NPs tested against E.faecium and C. albicans was 6.00 µg/mL (E. faecium and C. albicans). It was 32.00 µg/mL (S. aureus, S. typhimurium and Cryptococcus sp.), 64.00 µg/mL (P. aeruginosa), and 128 µg/mL (C. parapsilosis). Conclusion: As far as it is to our knowledge, this study established, for the first time, the biological activities of biosynthesized ZnO NPs from FSE and their synergistic therapeutic potential.

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Section: Results and Discussion Production And Characterization Of Znsupporting

confidence: 90%

<p>Therapeutic Potential Assessment of Green Synthesized Zinc Oxide Nanoparticles Derived from Fennel Seeds Extract</p>

AlSalhi¹,

Devanesan²,

Al-Qahtani³

et al. 2020

IJN

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“…In a recent study, different transition metal ions (Fe 2+ , Mn 2+ , and Co 2+ ) doped with nanosized hydroxyapatite (HA) were prepared for the increase of loadbearing capacity and strength; meanwhile, higher antibacterial activities were achieved against most tested bacteria compared with erythromycin (Panneerselvam et al, 2020). These transition metal elements (Fe, Mn, and Co) were also separately doped into CeO 2 NPs and proven to have enhanced antimicrobial activities (Khadar et al, 2019;Atif et al, 2019;Rahdar et al, 2019). The metal ions were placed into the atomic site of the Ce ions and substituted in the matrix of the host CeO 2 .…”

Section: Metal Element Doping Into Cerium Oxide Nps For Antibacterialmentioning

confidence: 99%

“…The metal ions were placed into the atomic site of the Ce ions and substituted in the matrix of the host CeO 2 . The bonding of metal ions with CeO 2 NPs was formed (Khadar et al, 2019;Atif et al, 2019;Rahdar et al, 2019). The antibacterial activity of various transition metal-doped metal oxide nanostructures comes from an electrostatic induction nature between NPs and the bacterial cell membrane (Khadar et al, 2019).…”

Section: Metal Element Doping Into Cerium Oxide Nps For Antibacterialmentioning

confidence: 99%

“…However, it was found that CeO 2 NPs at low concentrations (1 mg/L) could not destroy the bacterial biofilms (Hou et al, 2015). Therefore, various cerium-and cerium oxide-based nanomaterials including doping metal ions (Atif et al, 2019), antibacterial element Au/Ag decorations (Babu et al, 2014;Wang et al, 2014), nanocontainers (Gagnon et al, 2015), dopants (Bomila et al, 2018), and a component of blend (Pandey et al, 2018a) were developed to optimize antimicrobial performance as well as physical and biological properties (Anastasiou et al, 2019;Bharathi and Stalin, 2019;Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

Zheng

et al. 2020

Front. Mater.

109

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Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has helped to cure numerous infectious diseases and made huge contributions in the biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to serious drug resistance for many human bacterial pathogens. In particular, bacterial drug resistance decreases therapeutic effects and leads to high mortality. Inspiringly, the introduction of nanomaterials in the biomedical field makes it possible to overcome the difficulty in bacterial drug resistance attributed to their unique antibacterial mechanism. Recently, a variety of metal-and metal oxide-based nanomaterials have been fully integrated in antibacterial applications and achieved excellent performances. Among them, cerium-and cerium oxide-based nanomaterials have received much attention worldwide. Remarkably, cerium oxide nanoparticles with lower toxicity act as effective antibacterial agents owing to their unique functional mechanism against pathogens through the reversible conversion of oxidation state between Ce(III) and Ce(IV). This article provides an overview of the state-of-the-art design and antibacterial applications of cerium-and cerium oxidebased materials. The first part discusses the underlying antibacterial mechanisms for cerium-and cerium oxide-based materials currently applied in biomedicine. The second part focuses on various antibacterial-related materials and their applications. In addition, the existing problems and future perspectives of the cerium-and cerium oxide-based materials make up the third part of this review. This paper could provide the possible mechanisms for antibacterial activities, various designs of cerium-and cerium oxide-based materials, and related antibacterial properties.

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“…Given their shapes, they are classified into Zero-dimensional, onedimensional, and two-dimensional [4]. Recently, some of advanced types of metallic nanomaterials have been applied in pharmaceutical applications such as anti-cancer [5][6][7][8], antimicrobial [9,10] effects. QDs are considered as semi-conductive zero-dimensional nanocrystals with sizes in range of 1-20 nm.…”

Section: Introductionmentioning

confidence: 99%

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

Gholami

Dadmehr

Jelodar

et al. 2020

Mater. Res. Express

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Development of green based synthesis of nanoparticles has been regarded as a novel and safe alternative method compared to conventional methods. Semiconductor cadmium sulfide quantum dots (CdS QDs) possess unique biological and medical applications includes labeling cells, diagnosing of diseases and imaging intercellular events. The present paper reports the biosynthesis of CdS QDs through aqueous extracts of the regenerated hairy roots of Rhaphanus sativus L. as the organic source for both reducing and stabilizing of Cd and S precursor ions. The characterization of synthesized QDs showed maximum absorbance peak of 460 nm and fluorescence spectrum of cadmium sulfide at 530 nm. The results of Transmission Electron Microscope (TEM) and EDS analysis demonstrated that the particles were morphologically spherical with size distribution between 2-7 nm and confirmed presence of CdS QDs. Fourier transform infrared spectroscopy (FT-IR) also showed the active presence of aromatic, amino, and carboxyl groups on the surface of quantum dots. Cytotoxicity effect of the synthesized CdS QDs on two cell lines include MCF-7 breast cancer and AGS gastric cancer were assayed through MTT assay. The results showed significant inhibitory effects of synthesized QDs on treated cells in a dose dependent manner. It was also concluded that CdS QDs had more apoptosis effect on MCF-7 cells rather than AGS cell lines. The obtained results clearly illustrated that the synthesis of CdS quantum dots with standard features would be possible through costeffective, reliable, environmentally friendly and less toxic alternative method compared to chemical and physical processes and the MTT toxicity assay also illustrated the significant apoptotic effects of synthesized CdS QDs on carcinogenesis.

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Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity

Cited by 49 publications

References 37 publications

<p>Therapeutic Potential Assessment of Green Synthesized Zinc Oxide Nanoparticles Derived from Fennel Seeds Extract</p>

<p>Therapeutic Potential Assessment of Green Synthesized Zinc Oxide Nanoparticles Derived from Fennel Seeds Extract</p>

Cerium and Its Oxidant-Based Nanomaterials for Antibacterial Applications: A State-of-the-Art Review

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

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