Inhibition of Na, K-ATPase by sodium selenite and reversal by glutathione

Abstract

Sodium selenite has been shown to inhibit Na,K-ATPase. Glutathione, at sufficient excess, is able to prevent or reverse the inhibition. Dithiothreitol can also reverse much of the inhibition, but KCN cannot. Selenomethionine does not inhibit Na,K-ATPase. The interactions of sodium selenite with Na,K-ATPase and glutathione may aid in understanding the early events in selenium cataractogenesis.

The Effect of Resveratrol in Experimental Cataract Model Formed by Sodium Selenite

“…Resveratrol possibly protects against inhibition of Na + -K + -ATPase and Na + /Ca +2 exchange by detoxification of reactive oxygen radicals. 37,38 In our study, mean lens TN levels in group 2 and group 3 were significantly higher than in group 1 (p < 0.05). In addition, mean TN levels in group 3 were significantly higher than in group 2 (p < 0.05).…”

Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract

“…Possibly, GSPE may be preventing inhibition of the Ca-ATPase pump and selective calcium permeability by means of scavenging reactive oxygen radicals. 26,27 In a recent study, proanthocyanidins derived from cacao (CLP) were tested for their preventive effect on cataract development in rats with diabetes induced by streptozotocin. 28 The authors found that dietary supplementation with CLP did not affect hyperglycemia but made a significant change in production of hydroxynonenal, a marker of oxidative stress.…”

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

“…Among these proteins, NF-κB, AP-1, caspase-3, Cdk2, protein kinase C and JNK are known to act as redox-dependent signal molecules (35,(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Therefore, deregulation of target molecules by selenium-induced thiol modification may be involved in disrupting various signal transduction pathways that control cell survival and apoptosis.…”