Inhibition of Mumps and Influenza B Virus Multiplication by Synthetic Poly-D-Lysine.

Tsuyuki, Emee; Tsuyuki, H.; Stahmann, Mark A.

doi:10.3181/00379727-91-22249

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…An 11‐residue model peptide, 2 , was used for these experiments, which was then modified via incorporation of d ‐lysine to tune the stability of the molecule. As we expected a 100 % d ‐amino acid containing peptide to be proteolytically stable, we investigated decreased percentages of d ‐amino acids to allow us to assess a range of stabilities from these diastereomeric peptides, as well as any protection from the fluorinated side‐chain.…”

Section: Figurementioning

confidence: 99%

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

et al. 2017

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19F MRI is valuable for in vivo imaging due to the only trace amounts of fluorine in biological systems. Because of the low sensitivity of MRI however, designing new fluorochemicals remains a significant challenge for achieving sufficient 19F signal. Here, we describe a new class of high-signal, water-soluble fluorochemicals as 19F MRI imaging agents. A polyamide backbone is used for tuning the proteolytic stability to avoid retention within the body, which is a limitation of current state-of-the-art perfluorochemicals. We show that unstructured peptides containing alternating N-ε-trifluoroacetyllysine and lysine provide a degenerate 19F NMR signal. 19F MRI phantom images provide sufficient contrast at micromolar concentrations, showing promise for eventual clinical applications. Finally, the degenerate high signal characteristics were retained when conjugated to a large protein, indicating potential for in vivo targeting applications, including molecular imaging and cell tracking.

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Section: Figurementioning

confidence: 99%

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

et al. 2017

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“…An 11-residue model peptide, 2,w as used for these experiments,w hich was then modified via incorporation of d-lysine to tune the stability of the molecule.Asweexpected a100 % d-amino acid containing peptide to be proteolytically stable, [24] we investigated decreased percentages of d-amino acids to allow us to assess ar ange of stabilities from these diastereomeric peptides,a s well as any protection from the fluorinated side-chain. To probe this,w es ubjected our lysine-rich peptides to trypsin to monitor the rate of degradation.…”

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confidence: 99%

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

et al. 2017

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19 FM RI is valuable for in vivo imaging due to the only trace amounts of fluorine in biological systems.B ecause of the low sensitivity of MRI however,d esigning new fluorochemicals remains as ignificant challenge for achieving sufficient 19 Fs ignal. Here,w ed escribe an ew class of highsignal, water-soluble fluorochemicals as 19 FM RI imaging agents.Ap olyamide backbone is used for tuning the proteolytic stability to avoid retention within the body,w hichi s al imitation of current state-of-the-art perfluorochemicals.W e show that unstructured peptides containing alternating N-etrifluoroacetyllysine and lysine provide adegenerate 19 FNMR signal. 19 FMRI phantom images providesufficient contrast at micromolar concentrations,s howing promise for eventual clinical applications.F inally,t he degenerate high signal characteristics were retained when conjugated to al arge protein, indicating potential for in vivo targeting applications, including molecular imaging and cell tracking.

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N‐CARBOXY‐β‐AMINOSÄURE‐ANHYDRIDE UND IHRE POLYMERISATION

Birkofer¹,

Modic²

1957

Justus Liebigs Ann. Chem.

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56L. BIRKOFER und R. MODIC Bd. 604 wahrend die Stammlasung bei Raumtemperatur gehalten wurde. Ebenso wurden 0.4348 g Reduktinsaurel4) untersucht. c) Proben der Stammlosung von VIII wurden nach verschiedenen Zeiten mit Phosphatpuffer verdiinnt, mit mindestens 4 Aquiv. Jodlosung versetzt und nach 12 Stdn. zuriicktitriert. Die Ergebnisse zu b) und c) sind unter der Annahme berechnet, dal3 die Reduktone genau 2 Aquiv. Jod verbrauchen (Tab. 2). Tabelle 2. Jodometrische Titrationen 5-Ring-Redukton 7-Ring-Redukton (VIII) Titration nach (Reduktinsaure) Methode b b C 0 Min. 33 Min. 1 Stde. 3 Stdn. 5.5 Stdn. 22 Stdn. 30 Stdn. 44 Stdn. 97.5 % 49.6 103.1 % 96.9 % 96.8 % 96.1 % 40.6 % 102.5 % 95.8% 38.7 % 100.8% 90.8 % 16.7% 152.0 % 92.2% 21.7% 97.5 % 88.0% 5.4 % 1x2 % Ultruviolettspektren. Aufgenommen mit dem Zeil3-Universal-Spektrophotometer M 4 Q 11.Die Losungen wurden ganz frisch hergestellt. Substanz Konzentration (Mol/l) in HexanAlkohol n/20 NaOH

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Inhibition of Mumps and Influenza B Virus Multiplication by Synthetic Poly-D-Lysine.

Cited by 9 publications

References 3 publications

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

N‐CARBOXY‐β‐AMINOSÄURE‐ANHYDRIDE UND IHRE POLYMERISATION

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Inhibition of Mumps and Influenza B Virus Multiplication by Synthetic Poly-D-Lysine.

Cited by 9 publications

References 3 publications

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal 19F MRI Agents

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal 19F MRI Agents

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal 19F MRI Agents

N‐CARBOXY‐β‐AMINOSÄURE‐ANHYDRIDE UND IHRE POLYMERISATION

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Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High‐Signal ¹⁹F MRI Agents