Inhibition of Mitochondrial Lipid Peroxidation by Bakuchiol, a Meroterpene from Psoralea corylifolia

Haraguchi, Hiroyuki; Inoue, Junji; Tamura, Yukiyoshi; Mizutani, Kenji

doi:10.1055/s-2000-8605

Cited by 54 publications

(30 citation statements)

References 12 publications

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“…Bakuchiol has been shown to activate nuclear factor erythroid 2‐related factor 2, a transcription factor that plays a significant role in cellular resistance to oxidative stess . Additional antioxidant capabilities include its capacity for scavenging oxygen free radicals and its significant role in preventing mitochondrial lipid peroxidation …”

Section: Discussionmentioning

confidence: 99%

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

et al. 2018

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“…Bakuchiol was found to have cytotoxic activity against L929 cells in cell culture, and this cytotoxic activity was considered to be due to injury of the cell membrane, based on electron microscopic observation and hemolytic activity (15). Recently, various biological activities of bakuchiol have been reported, e.g., anti-inflammatory effects (3), inhibition of mitochondrial lipid peroxidation (6), stimulation of the immune system (18), inhibition of DNA polymerase (28), inhibition of papilloma formation (17), and prevention of diabetes (11). Therefore, bakuchiol might be a promising lead compound for development of antimicrobial agents against oral pathogens in humans.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activities of Bakuchiol against Oral Microorganisms

Katsura¹,

Tsukiyama²,

Suzuki³

et al. 2001

Antimicrob Agents Chemother

179

112

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Bakuchiol was isolated from the seeds of Psoralea corylifolia, a tree native to China with various uses in traditional medicine, followed by extraction with ether and column chromatography combined with silica gel and octyldecyl silane. In this study, the antimicrobial activities of bakuchiol against some oral microorganisms were evaluated in vitro. The cell growth of Streptococcus mutans was inhibited in a bakuchiol concentrationdependent manner, and growth of S. mutans was completely prevented by 20 g of bakuchiol per ml. The bactericidal effect of bakuchiol on S. mutans was dependent on temperature and stable under the following conditions: sucrose, 0 to 10% (wt/vol); pH, 3.0 to 7.0; organic acids (3% [wt/vol] citric and malic acids). Bakuchiol showed bactericidal effects against all bacteria tested, including S. mutans, Streptococcus sanguis, Streptococcus salivarius, Streptococcus sobrinus, Enterococcus faecalis, Enterococcus faecium, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Actinomyces viscosus, and Porphyromonas gingivalis, with MICs ranging from 1 to 4 g/ml and the sterilizing concentration for 15 min ranging from 5 to 20 g/ml. Furthermore, bakuchiol was also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose and inhibited the reduction of pH in the broth. Thus, bakuchiol would be a useful compound for development of antibacterial agents against oral pathogens and has great potential for use in food additives and mouthwash for preventing and treating dental caries.

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“…In connection with this, several Yang herbs have been shown to possess antioxidant activity both in vitro and in vivo [33]. Studies from various laboratories showed that Yang tonic herbs produced antioxidant actions by free radical-scavenging [34], inhibition of oxidant production [35], inhibition of NADPH-dependent lipid peroxidation [36] and increase of antioxidant enzyme activities [37], with a resultant protection against oxidative tissue damage. These findings were consistent with our earlier study which showed that Yang tonic herbs possessed stronger free radical scavenging activity than that of tonic herbs of other functional categories [38].…”

Section: Pharmacological Basis Of "Yang-invigoration" In Chinese Medimentioning

confidence: 99%

A Hypothetical Anti-Aging Mechanism of “Yang-Invigorating” Chinese Tonic Herbs

Lam¹,

Wong²,

Chen³

et al. 2012

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Chinese tonic herbs are generally classified into Yin and Yang categories based on their health-promoting action. Emerging evidence has suggested that in addition to up-regulating mitochondrial functional status, Yang tonic herbs also enhance cellular/mitochondrial antioxidant capacity, and may thus prevent age-related diseases and prolong the healthy part of lifespan (i.e. healthspan). The proposed biochemical mechanism underlying the antioxidant action of Yang tonic herbs involves a sustained and low level of mitochondrial reactive oxygen species production, which is secondary to the increased activity of the electron transport chain, with the possible involvement of mitochondrial uncoupling. “Yang invigoration” improves antioxidant defense in the body in the long term and thereby offers a promising prospect for preventing or possibly delaying age-related diseases and the detrimental effects of aging

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Inhibition of Mitochondrial Lipid Peroxidation by Bakuchiol, a Meroterpene from Psoralea corylifolia

Cited by 54 publications

References 12 publications

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

In Vitro Antimicrobial Activities of Bakuchiol against Oral Microorganisms

A Hypothetical Anti-Aging Mechanism of “Yang-Invigorating” Chinese Tonic Herbs

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