Inhibition of Mast Cell‐Dependent Allergy Reaction by Extract of Black Cohosh (Cimicifuga racemosa)

Kim, Chang Deok; Lee, Won-Kyung; Cho, Ho Song; Lee, Yong Koo; Roh, Seok-Seon

doi:10.1081/iph-120037728

Cited by 24 publications

(14 citation statements)

References 23 publications

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“…For preparations combining Hypericum and C. racemosa extracts, however, allergic skin reactions have been reported. On the other hand, recent studies on the potential effects of black cohosh extract (BCE) could also demonstrate that oral administration of BCE may inhibit mast cell-dependent allergic reactions [9]. To the best of our knowledge, this is the first report on the occurrence of PL of the skin induced by C. racemosa rhizoma extract.…”

Section: Discussionmentioning

confidence: 84%

Cutaneous Pseudolymphoma Induced by Cimicifuga racemosa

Meyer

Vogt²,

Obermann³

et al. 2006

Dermatology

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We report a 56-year-old female patient who presented with asymptomatic, localized erythematous plaques on arms and legs. Histologically, the diagnosis of pseudolymphoma (PL) was confirmed. Because of menopausal complaints, the patient had been taking Remifemin®, a phytotherapeutical agent containing a standardized extract of black cohosh (Cimicifuga racemosa) rhizome for 1 year. Six months after initial administration of this herbal drug, first skin lesions appeared which continuously increased. Withdrawal of Remifemin resulted in regression and complete remission of the lesions within 12 weeks. To the best of our knowledge, this is the first report on cutaneous PL induced by a standardized extract of C. racemosa rhizoma. Thus, though claimed to be poor in adverse effects, the potency of phytotherapeutical agents to induce uncommon cutaneous eruptions needs to be taken into careful reconsideration since the course of cutaneous PL tends to be chronic and indolent if the causative agent is not discontinued.

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Section: Discussionmentioning

confidence: 84%

Cutaneous Pseudolymphoma Induced by Cimicifuga racemosa

Meyer

Vogt²,

Obermann³

et al. 2006

Dermatology

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“…Several biological activities have been reported for black cohosh. Based on the traditional use of A. racemosa extract to relieve pain and inflammation, Kim et al [7] conducted a study in which they tested the potential effects of A. racemosa extracts on the allergic response of mast cells. Oral administration of the extract to rats led to a significant inhibition of the anti-IgE-induced passive cutaneous anaphylaxis reaction in a dose-dependent manner.…”

Section: Introductionmentioning

confidence: 99%

Hyperspectral Imaging and Support Vector Machine: A Powerful Combination to Differentiate Black Cohosh (Actaea racemosa) from Other Cohosh Species

et al. 2017

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(black cohosh) has a history of traditional use in the treatment of general gynecological problems. However, the plant is known to be vulnerable to adulteration with other cohosh species. This study evaluated the use of shortwave infrared hyperspectral imaging (SWIR-HSI) in tandem with chemometric data analysis as a fast alternative method for the discrimination of four cohosh species () and 36 commercial products labelled as black cohosh. The raw material and commercial products were analyzed using SWIR-HSI and ultra-high-performance liquid chromatography coupled to mass spectrometry (UHPLC-MS) followed by chemometric modeling. From SWIR-HSI data (920 - 2514 nm), the range containing the discriminating information of the four species was identified as 1204 - 1480 nm using Matlab software. After reduction of the data set range, partial least squares discriminant analysis (PLS-DA) and support vector machine discriminant analysis (SVM-DA) models with coefficients of determination ( ) of ≥ 0.8 were created. The novel SVM-DA model showed better predictions and was used to predict the commercial product content. Seven out of 36 commercial products were recognized by the SVM-DA model as being true black cohosh while 29 products indicated adulteration. Analysis of the UHPLC-MS data demonstrated that six commercial products could be authentic black cohosh. This was confirmed using the fragmentation patterns of three black cohosh markers (cimiracemoside C; 12-,21-dihydroxycimigenol-3--L-arabinoside; and 24--acetylhydroshengmanol-3---D-xylopyranoside). SWIR-HSI in conjunction with chemometric tools (SVM-DA) could identify 80% adulteration of commercial products labelled as black cohosh.

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“…[8] Furthermore, CR extracts exhibited antiallergic activity due to inhibition of histamine release and induction of IL-4, IL-5 and TNFa mRNA in human leukaemia mast cells. [37] Conclusions Our data suggest that the inhibitory effect of CR extracts on inducible NO production is due to inhibition of iNOS expression. Among the triterpene glycosides, 23-epi-26deoxyactein was an inhibitor of inducible NO production in LPS-stimulated macrophages.…”

Section: Discussionmentioning

confidence: 70%