Inhibition of inducible nitric oxide synthesis by &lt;I&gt;Cimicifuga racemosa&lt;/I&gt; (&lt;I&gt;Actaea racemosa&lt;/I&gt;, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages

Schmid, Diethart; Gruber, Miriam; Woehs, Florian; Prinz, Sonja; Etzlstorfer, Barbara; Prucker, Christina; Fuzzati, Nicola; Kopp, Brigitte; Moeslinger, Thomas

doi:10.1211/jpp/61.08.0013

Cited by 13 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extracts from Eucalyptus globulus Labill. and Thymus vulgaris L., [29] Saposhnikovia divaricata , [ 30] Pinus sylvestris L and Plantago lanceolata L., [31] Acanthopanax senticosus , [ 32] Cimicifuga racemosa (aqueous) [33] and Actinodaphne lancifolia (methanolic) [34] confirmed the inhibitory activity on NO production in LPS‐activated macrophage cells at translational and post‐translational levels. In addition, the two main thyme compounds (thymol and carvacrol) displayed concentration‐dependent antioxidant capacity and showed a protective effect against oxidative damage in human lymphocytes and V97 Chinese hamster lung fibroblast cells, while γ ‐terpinene, which lacks a phenolic group, did not show any antioxidant capacity [35,36] .…”

Section: Discussionmentioning

confidence: 76%

Inhibitory effects of Zataria multiflora essential oil and its main components on nitric oxide and hydrogen peroxide production in lipopolysaccharide-stimulated macrophages

Kavoosi

Silva

Saharkhiz

2012

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 76%

Inhibitory effects of Zataria multiflora essential oil and its main components on nitric oxide and hydrogen peroxide production in lipopolysaccharide-stimulated macrophages

Kavoosi

Silva

Saharkhiz

2012

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…The ethyl acetate fraction of the aqueous extract of C. racemosa was also shown to suppress the release of TNF-α, due to cimiracemate A [554]. Aqueous extracts reduced inducible nitric oxide synthase (iNOS) protein expression as well as iNOS mRNA levels, but did not inhibit iNOS enzymatic activity; the triterpenoid glycoside 23-epi-26-deoxyactein was found to be the active principle in the extract [555]. These effects likely explain the anti-inflammatory activities of C. racemosa and their traditional uses to treat rheumatism and other inflammatory diseases.…”

Section: Caulophyllum Thalictroides (L) Michxmentioning

confidence: 99%

The Phytochemistry of Cherokee Aromatic Medicinal Plants

Setzer

2018

Medicines

View full text Add to dashboard Cite

Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines.

show abstract

Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites

et al. 2010

View full text Add to dashboard Cite

Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa, Nutt., Ranunculaceae) is a popular herb used for relieving menopausal discomforts. A variety of secondary metabolites, including triterpenoids, phenolic dimers, and serotonin derivatives have been associated with its biological activity, but the genes and metabolic pathways as well as the tissue distribution of their production in this plant are unknown. A gene discovery effort was initiated in A. racemosa by partial sequencing of cDNA libraries constructed from young leaf, rhizome, and root tissues. In total, 2,066 expressed sequence tags (ESTs) were assembled into 1,590 unique genes (unigenes). Most of the unigenes were predicted to encode primary metabolism genes, but about 70 were identified as putative secondary metabolism genes. Several of these candidates were analyzed further and full-length cDNA and genomic sequences for a putative 2,3 oxidosqualene cyclase (CAS1) and two BAHD-type acyltransferases (ACT1 and HCT1) were obtained. Homology-based PCR screening for the central gene in plant serotonin biosynthesis, tryptophan decarboxylase (TDC), identified two TDC-related sequences in A. racemosa. CAS1, ACT1, and HCT1 were expressed in most plant tissues, whereas expression of TDC genes was detected only sporadically in immature flower heads and some very young leaf tissues. The cDNA libraries described and assorted genes identified provide initial insight into gene content and diversity in black cohosh, and provide tools and resources for detailed investigations of secondary metabolite genes and enzymes in this important medicinal plant.

show abstract

Inhibition of inducible nitric oxide synthesis by <I>Cimicifuga racemosa</I> (<I>Actaea racemosa</I>, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages

Abstract: Extracts from the roots of C. racemosa inhibit nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. This might contribute to the anti-inflammatory activities of C. racemosa.

Cited by 13 publications

References 29 publications

Inhibitory effects of Zataria multiflora essential oil and its main components on nitric oxide and hydrogen peroxide production in lipopolysaccharide-stimulated macrophages

Inhibitory effects of Zataria multiflora essential oil and its main components on nitric oxide and hydrogen peroxide production in lipopolysaccharide-stimulated macrophages

The Phytochemistry of Cherokee Aromatic Medicinal Plants

Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites

Contact Info

Product

Resources

About