Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene

Hirose, Masao; Hoshiya, Toru; Akagi, Keisuke; Futakuchi, Mitsuru; Ito, Nobuyuki

doi:10.1016/0304-3835(94)90312-3

Cited by 101 publications

(42 citation statements)

References 14 publications

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“…1,24 There is some supportive evidence in rodent breast cancer models that green tea catechins fed in the diet are associated with a reduction of chemically induced mammary gland carcinogenesis. 29,30 In addition, female rats given green tea as their drinking fluid displayed a significant decrease in carcinogen-induced mammary tumor burden and invasiveness and significantly delayed latency to first tumor. 31 Tea polyphenol may influence breast cancer risk via various mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Green tea and risk of breast cancer in Asian Americans

Tseng

et al. 2003

Intl Journal of Cancer

310

270

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There is substantial in vitro and in vivo evidence implicating tea polyphenols as chemopreventive agents against various cancers. However, epidemiologic data obtained from mainly Western populations are not supportive of a protective role of tea, mainly black tea, in the etiology of breast cancer. Much less is known about the relationship between green tea and breast cancer risk. During 1995-1998, we conducted a population-based, case-control study of breast cancer among Chinese, Japanese and Filipino women in Los Angeles County and successfully interviewed 501 breast cancer patients and 594 control subjects. Detailed information on menstrual and reproductive factors; dietary habits, including intake of black and green tea; and other lifestyle factors was collected. Risk of breast cancer was not related to black tea consumption. In contrast, green tea drinkers showed a significantly reduced risk of breast cancer, and this was maintained after adjusting for age, specific Asian ethnicity, birthplace, age at menarche, parity, menopausal status, use of menopausal hormones, body size and intake of total calories and black tea. Compared to women who did not drink green tea regularly (i.e., less than once a month), there was a significant trend of decreasing risk with increasing amount of green tea intake, adjusted odds ratios being 1.00, 0.71 (95% confidence interval [CI] 0.51-0.99) and 0.53 (95% CI 0.35-0.78), respectively, in association with no, 0 -85.7 and >85.7 ml of green tea per day. The significant inverse association between risk of breast cancer and green tea intake remained after further adjustment for other potential confounders, including smoking; alcohol, coffee and black tea intake; family history of breast cancer; physical activity; and intake of soy and dark green vegetables. While both green tea and soy intake had significant, independent protective effects on breast cancer risk, the benefit of green tea was primarily observed among subjects who were low soy consumers. Similarly, the protective effect of soy was primarily observed among subjects who were nondrinkers of green tea. In summary, our results point to an important role of both green tea and soy intake in relation to breast cancer risk in Asian-American women.

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Section: Discussionmentioning

confidence: 99%

Green tea and risk of breast cancer in Asian Americans

Tseng

et al. 2003

Intl Journal of Cancer

310

270

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“…17 In various studies, rats with breast tumors that were given green tea had reductions in tumor size and tumor growth. 18,19 Some human case-control studies suggest protective effects of polyphenols against breast cancer specifically. 20 These findings, coupled with observations of lower rates of breast cancer in countries where green tea is consumed daily, suggest that green tea may protect against human breast cancer.…”

mentioning

confidence: 99%

Coffee, tea, caffeine and risk of breast cancer: A 22‐year follow‐up

Ganmaa

Willett

et al. 2008

Intl Journal of Cancer

118

124

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The relation between consumption of coffee, tea and caffeine and risk of breast cancer remains unsettled. We examined data from a large, long-term cohort study to evaluate whether high intake of coffee and caffeine is associated with increased risk of breast cancer. This was a prospective cohort study with 85,987 female participants in the Nurses' Health Study. Consumption of coffee, tea and caffeine consumption was assessed in 1980, 1984, 1986, 1990, 1994, 1998 and the follow-up continued through 2002. We documented 5,272 cases of invasive breast cancer during 1,715,230 person-years. The multivariate relative risks (RRs) of breast cancer across categories of caffeinated coffee consumption were: 1.0 for <1cup/month (reference category), 1.01 (95% confidence interval: 0.92-1.12) for 1 month to 4.9 week, 0.92 (0.84-1.01) for 5 week to 1.9 days, 0.93 (0.85-1.02) for 2-3.9 days, 0.92 (0.82-1.03) for 4 cups per day (p for trend 5 0.14). Intakes of tea and decaffeinated coffee were also not significantly associated with risk of breast cancer. RRs (95% CI) for increasing quintiles of caffeine intake were 1.00, 0.98 (0.90-1.07), 0.92 (0.84-1.00), 0.94 (0.87-1.03) and 0.93 (0.85-1.01) (p for trend 5 0.06). A significant inverse association of caffeine intake with breast cancers was observed among postmenopausal women; for the highest quintile of intake compared to the lowest RR 0.88 (95% CI 5 0.79-0.97, p for trend 5 0.03). We observed no substantial association between caffeinated and decaffeinated coffee and tea consumption and risk of breast cancer in the overall cohort. However, our results suggested a weak inverse association between caffeine-containing beverages and risk of postmenopausal breast cancer.

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“…The ability of phytic acid to reverse DMBA induced-proliferative changes in rats not only agrees with previous reports in experimental skin, colon and breast carcinogenesis models but also suggest its anti-proliferative properties. [21][22][23][24] This antiproliferative effect of IP-6 may be due to its ability to: (1) enhance baseline Natural Killer cell activity with subsequent destruction of the transformed cells; 21 (2) downregulate genes involved in transcription and cell cycle regulation and to upregulate cell cycle inhibitors 25 and (3) induce apoptotic machinery and to inhibits cell survival signaling. 26 The ability of IP-6 to induce apoptotic activity in our series is in accord with previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…28 Moreover, IP-6 was able to inhibits DMBA-induced mouse skin and mammary tumor development. 23,27 The decreased level of NO following IP-6 administration may be explained by its antioxidant activity. In support, intrinsic IP-6 in corn and soy was protective against lipid peroxidation in colon of pigs.…”

Section: Discussionmentioning

confidence: 99%

The biochemical changes associated with phytic acid on induced breast proliferative lesions in rats: Preliminary findings

Hussein¹,

El-Aziz²,

Ahmad³

et al. 2006

Cancer Biology & Therapy

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Background: Phytic acid is an anti-neoplastic agent. We hypothesize that during mammary tumorigenesis, the administration of phytic acid is associated with biochemical changes including enhancement of apoptosis and inhibition of oxidative stress.Materials and methods: An animal model formed of 25 rats was established. The animals were divided into three groups: (1) a control group which received the same phytic acid treatment in the right route and amount; (2) a carcinogen group which received a carcinogenic substance DMBA that can induce proliferative changes in the mammary gland; (3) treated group which received phytic acid, 60 days after the intake of DMBA. The animals were sacrificed, serum and tissue were evaluated for markers of tumorigenicity (serum total sialic acid, TSA); apoptotic changes (tissue caspase-3 activity and % DNA Fragmentation) and oxidative stress (tissue level of nitric oxide, NO).Results: Following DMBA administration, benign proliferative breast changes occurred in all animals. However, these changes disappeared following phytic acid treatment. As compared to the control group, the development of these proliferative changes in DMBA group was associated with statistically significantly (p < 0.05) increased levels of TSA and NO and decreased apoptotic activity. When compared to DMBA group, the disappearance of the proliferative changes in phytic acid -treated group was associated with statistically significantly (p < 0.05) decreased levels of TSA and NO and increased apoptotic activity.Conclusions: Administration of phytic acid reversed the proliferative effects of DMBA, suggesting its protective role.

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Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene

Cited by 101 publications

References 14 publications

Green tea and risk of breast cancer in Asian Americans

Green tea and risk of breast cancer in Asian Americans

Coffee, tea, caffeine and risk of breast cancer: A 22‐year follow‐up

The biochemical changes associated with phytic acid on induced breast proliferative lesions in rats: Preliminary findings

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