Inhibition of liver glutathione S-transferase placental form-positive foci development in the rat hepatocarcinogenesis by Porphyra tenera (Asakusa-nori)

Ichihara, Toshio; Wanibuchi, Hideki; Taniyama, Tetsuhide; Okai, Yasuji; Yano, Yoshihisa; Otani, Shuzo; Imaoka, Shingi; Funae, Yoshihiko; Fukushima, Shoji

doi:10.1016/s0304-3835(99)00106-8

Cited by 18 publications

(12 citation statements)

References 29 publications

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“…Anti-cancer polysaccharides (dietary fiber, porphyran), phospholipids, sterol, peptide [17,[46][47][48][49][50][51][52][53][54] Prevention of cardiovascular disease (e.g., hypertension, atherosclerosis, ischemia) betaine, dietary fiber, taurine, porphyran [17,[55][56][57][58][59][60][61] Antioxidant effect (e.g., Anti-ageing) porphyran, glycoprotein, polyphenols, tocopherols, peptide [62][63][64][65][66][67] Anti-inflammatory effect and immunomodulation glycoprotein, porphyran [64,[68][69][70][71][72][73] Alcohol metabolism glycoprotein [74,75] Prevention of nervous diseases (e.g., Alzheimer's diseases, methylmalonic acidemias) taurine, porphyran [38,76,77] Prevention of bone disease (e.g., osteoporosis, rheumatoid arthritis) porphyran, glycoprotein [64,78] Anti-diabetes mellitus phenolic compounds (carotenoids, anthocyanins), polysaccharides (porphyran), peptide [79][80][81][82] Porphyran is the distinctive dietary fiber found in laver, and its health effects were intensively studied to determine the nutritional/functional quality of ...…”

Section: Health Functionality Major Components Linked To Health Functmentioning

confidence: 99%

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

Cho

Rhee

2019

Marine Drugs

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The growing interest in laver as a food product and as a source of substances beneficial to health has led to global consumer demand for laver produced in a limited area of northeastern Asia. Here we review research into the benefits of laver consumption and discuss future perspectives on the improvement of laver product quality. Variation in nutritional/functional values among product types (raw and processed (dried, roasted, or seasoned) laver) makes product-specific nutritional analysis a prerequisite for accurate prediction of health benefits. The effects of drying, roasting, and seasoning on the contents of both beneficial and harmful substances highlight the importance of managing laver processing conditions. Most research into health benefits has focused on substances present at high concentrations in laver (porphyran, Vitamin B 12 , taurine), with assessment of the expected effects of laver consumption. Mitigation of chemical/microbiological risks and the adoption of novel technologies to exploit under-reported biochemical characteristics of lavers are suggested as key strategies for the further improvement of laver product quality. Comprehensive analysis of the literature regarding laver as a food product and as a source of biomedical compounds highlights the possibilities and challenges for application of laver products.

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Section: Health Functionality Major Components Linked To Health Functmentioning

confidence: 99%

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

Cho

Rhee

2019

Marine Drugs

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“…It is used as a folk medicine in various types of allergic diseases (Kimiya et al, 2008) and inflammatory diseases such as lymphadenitis, bronchitis. Several ethnopharmacological studies have been conducted on various Porphyra species, indicating their effectiveness in the treatment of stomachache, vomiting and diarrhea (Kim et al, 2006), hypersensitivity (Ishihara et al, 2005;Kimiya et al, 2008), nephritic and cordis diseases (Zhao et al, 2008), cancers (Ichihara et al, 1999;Okai et al, 1996) and acute liver injury (Guo et al, 2007). Phenolic compounds, such as rutin, hesperidin, morin, caffeic acid, catechol (Yoshie et al, 2003), catechin and epigallocatechin gallate (EGCG) (Yoshie et al, 2000), have been identified in Porphyra genus.…”

mentioning

confidence: 98%

Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata

Kazłowska

Hsu

Hou

et al. 2010

Journal of Ethnopharmacology

167

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“…animals 6,17,23 . Using rats from Japan Charles River Co., it is well known that numbers and areas per cm 2 of GST-P positive foci in the liver in the Ito test are increased significantly in PB treated rats compared with control groups given DEN alone 7,[14][15][16][17][18][24][25][26][27] . According to those studies, the number of GST-P positive foci in the liver of control groups ranged from 3.6 ± 1.8 to 5.8 ± 2.4; the area of GST-P positive foci in the livers of control groups ranged from 0.24 ± 0.23 to 0.56 ± 0.35; the number of GST-P positive foci in the livers of PB-treated groups ranged from 7.2 ± 2.8 to 13.9 ± 2.9; and the area of GST-P positive foci in the livers of PBtreated groups ranged from 0.94 ± 0.61 to 1.76 ± 0.74.…”

Section: Discussionmentioning

confidence: 99%

Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity

et al. 2006

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To examine potential variations in sensitivity of F344 rats from different breeders to carcinogens, groups of forty 6-week-old males from CLEA Inc., SLC Co., USA Charles River Co., and Japan Charles River Co. were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p., and 2 weeks later, they were given phenobarbital (PB) at a dose of 500 ppm. in the diet for 6 weeks and then sacrificed; all rats being subjected to two-thirds partial hepatectomy (PH) at week 3. Numbers and areas per cm 2 of preneoplastic lesions, glutathione S-transferase placental form (GST-P) positive foci in the liver in this Ito test, were increased significantly in PB treated rats from all breeders compared with the corresponding control groups given DEN alone. The number of GST-P positive foci in animals from CLEA Japan, however, increased more than in rats from the other breeders. Assessment with Affymetrix Rat Genome 230 2.0 cDNA microarrays, revealed common changes in expression of genes between treated and control group rats from all sources. Hierarchical cluster analysis revealed the gene expression pattern to be quite similar for rats from USA Charles River Co. and Japan Charles River Co. Although the differences are very subtle, sensitivity of F344 rats to carcinogens may vary depending on breeders.

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Inhibition of liver glutathione S-transferase placental form-positive foci development in the rat hepatocarcinogenesis by Porphyra tenera (Asakusa-nori)

Cited by 18 publications

References 29 publications

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata

Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity

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