Inhibition of Lipolytic Activity of Human Growth Hormone With Sheep Prolactin Derivative (Anaprolactin)

Abstract

An acute experiment involving the suppressing of the lipolytic activity of human growth hormone (HGH) with sheep acetyl prolactin has been carried out. The experiment is based on the similarity of the physicochemical properties of native sheep prolactin and human somatotrophin. The derivative obtained inhibits the lipolytic activity of HGH to the same extent as acetylated and iodinated human somatotrophin. Similarly modified albumin and casein appear to produce no inhibitory effect, thus revealing the specific character of the anti-hormonal effect of hormone derivatives obtained. There is good reason for believing that acetylated sheep prolactin (anaprolactin) is a competing anahormone. The data on three types of anahormones are discussed.

Bromocriptine Alters Hormone Rhythms and Lipid Metabolism in Swine

“…Results of several stud ies seem contradictory, indicating stimula tory as well as inhibitory effects of prolactin upon lipid mobilization from adipose tissue [33][34][35][36], Perhaps the effects of prolactin on fat mobilization are also time of day-depen dent. We are presently investigating this pos sibility.…”

Para-Endocrine Tumor Activity with Emphasis on Ectopic ADH Secretion

“…Diagnostic and therapeutic means such as intracellular localization of gonadotropins by immuno fluorescence [8,23] or even administration of gonadotropin antiserum or other antisera directed against respective para-endocrine tumor activity may prove to be useful diagnostic and therapeutic procedures not only in such animal tumors, but also in hormonally active human cancers. Also anahormones -chemically modified hormones which have lost their hormonal activity while they have retained their antigenic specificity and binding affinity to respective hormonal target cells -may be investigated in regard to their possible placement in para-endocrine tumor diagnostic and treatment [39], Anahormones are prepared from respective normal hormones (HGH, ACTH, insulin, gonadotropins) by iodination, acetylation, and oxidation [59] and they can compete with the respective native hormone. Because paraendocrine hormones may support growth and malignant potentials of their 410 VORHERR own tumor cells, anahormones may prove useful in locating ectopically active tissues and inhibiting their growth.…”