Inhibition of key digestive enzymes related to hyperlipidemia and protection of liver-kidney functions by Cystoseira crinita sulphated polysaccharide in high-fat diet-fed rats

Gara, Amel Ben; Kolsi, Rihab Ben Abdallah; Chaaben, Rim; Hammami, Nadia; Kammoun, Majed; Patti, Francesco Paolo; Feki, Abdelfattah El; Fki, Lotfi; Belghith, Hafedh; Belghith, Karima

doi:10.1016/j.biopha.2016.11.059

Cited by 35 publications

(18 citation statements)

References 37 publications

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“…In the present study, we observed that the HFD decreased the serum urea levels, which disagrees with an HFD treatment for 6 weeks that increased urea levels [63]. Since urea results from the degradation of protein, an enhancement in urea levels should have been expected, although that was not verified in our study.…”

Section: Discussioncontrasting

confidence: 99%

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

et al. 2018

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High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects.

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Section: Discussioncontrasting

confidence: 99%

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

et al. 2018

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“…In present study, although the liver weight was increased in the model group, there was no statistical difference among control, model and AEE groups. It is worth noting that increasing studies have showed that lipid disorders could cause decline of renal function caused by oxidative or pathological damages [34, 35]. In present study, CREA showed no difference and urea was significantly reduced in model and AEE groups.…”

Section: Discussioncontrasting

confidence: 49%

Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia

Liu

Kong

et al. 2018

BMC Vet Res

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BackgroundHyperlipidemia, with an increasing of prevalence, has become one of the common metabolic diseases in companion animal clinic. Aspirin eugenol ester (AEE) is a novel compound that exhibits efficacious anti-hyperlipidemia activities. However, its mechanisms are still not completely known. The objective of present study was to investigate the intervention effects of AEE on cecal contents metabonomics profile and microbiota in hyperlipidemia rats.ResultsThree groups of rats were fed with a control diet, or high fat diet (HFD) containing or not AEE. The results showed the beneficial effects of AEE in HFD-fed rats such as the reducing of aspartate aminotransferase (AST) and total cholesterol (TCH). Distinct changes in metabonomics profile of cecal contents were observed among control, model and AEE groups. HFD-induced alterations of eight metabolites in cecal contents mainly related with purine metabolism, linoleic acid metabolism, glycerophospholipid metabolism, sphingolipid metabolism and pyrimidine metabolism were reversed by AEE treatment. Principal coordinate analysis (PCoA) and cluster analysis of microbiota showed altered patterns with distinct differences in AEE group versus model group, indicating that AEE treatment improved the negative effects caused by HFD on cecal microbiota. In addition, the correction analysis revealed the possible link between the identified metabolites and cecal microbiota.ConclusionsThis study showed regulation effects of AEE on cecal contents metabonomics profile and microbiota, which could provide information to reveal the possible underlying mechanism of AEE on hyperlipidemia treatment.Electronic supplementary materialThe online version of this article (10.1186/s12917-018-1711-x) contains supplementary material, which is available to authorized users.

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“…Zha et al reported that crude polysaccharides from Laminaria japonica at a dose of 400 mg/kg/day caused a reduction in total serum cholesterol, TG, high density lipoprotein (HDL)-cholesterol, and LDL in serum [ 104 ]. In vivo administration of the sulfated polysaccharides from Cystoseira crinite to high-fat-diet rats led to a notable decrease in blood LDL and TG levels, but an increase in HDL levels [ 105 ]. Cao et al reported that porphyran from Pyropia yezoensis at a dose of 200 mg/kg/day can decrease the percentage of body weight gain and serum lipid profiles of mice, similar to the effect of a hypolipidemic drug [ 106 ].…”

Section: Biological Activity Of Polysaccharides From Marine Algaementioning

confidence: 99%

Recent Advances in Marine Algae Polysaccharides: Isolation, Structure, and Activities

2017

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Marine algae have attracted a great deal of interest as excellent sources of nutrients. Polysaccharides are the main components in marine algae, hence a great deal of attention has been directed at isolation and characterization of marine algae polysaccharides because of their numerous health benefits. In this review, extraction and purification approaches and chemico-physical properties of marine algae polysaccharides (MAPs) are summarized. The biological activities, which include immunomodulatory, antitumor, antiviral, antioxidant, and hypolipidemic, are also discussed. Additionally, structure-function relationships are analyzed and summarized. MAPs’ biological activities are closely correlated with their monosaccharide composition, molecular weights, linkage types, and chain conformation. In order to promote further exploitation and utilization of polysaccharides from marine algae for functional food and pharmaceutical areas, high efficiency, and low-cost polysaccharide extraction and purification methods, quality control, structure-function activity relationships, and specific mechanisms of MAPs activation need to be extensively investigated.

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Inhibition of key digestive enzymes related to hyperlipidemia and protection of liver-kidney functions by Cystoseira crinita sulphated polysaccharide in high-fat diet-fed rats

Cited by 35 publications

References 37 publications

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia

Recent Advances in Marine Algae Polysaccharides: Isolation, Structure, and Activities

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