Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers

Pongkorpsakol, Pawin; Wongkrasant, Preedajit; Kumpun, Saowanee; Chatsudthipong, Varanuj; Muanprasat, Chatchai

doi:10.1016/j.phrs.2015.08.012

Cited by 28 publications

(18 citation statements)

References 31 publications

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“…[ 2 3 ] Focusing on the gastrointestinal effect, there is a new evidence that piperine from black pepper can act against diarrhea. [ 4 ] However, we hereby present an observation against this recent finding. The patient is a case with underlying short bowel syndrome with controllable bowel frequency.…”

contrasting

confidence: 43%

Black pepper: Stimulation of diarrhea in patient with underlying short bowel syndrome

Chaiyasit¹,

Wiwanitkit²

2016

Ancient Sci Life

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contrasting

confidence: 43%

Black pepper: Stimulation of diarrhea in patient with underlying short bowel syndrome

Chaiyasit¹,

Wiwanitkit²

2016

Ancient Sci Life

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“…Piperine (1-piperoyl piperidine, PIP), an abundant alkaloid compound in Piper longum L. (long pepper) and Piper nigrum L. (white or black pepper), exhibits a number of beneficial effects including anti-cancer, anti-inflammation, immunomodulatory, antispasmodic and anti-secretory effects [ 18 – 22 ]. In addition to these pharmacological effects, PIP has been found to significantly inhibit the activities of metabolic enzymes such as CYPs, UDP-glucuronosyltransferase, sulfotransferase, aryl hydroxyoase and O-deethylase [ 23 – 25 ], and selectively inhibit the function of CYP3A4 [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination-in vitroandin vivoinvestigation using a taxane-resistant prostate cancer model

Wang

et al. 2017

Oncotarget

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Docetaxel (DTX) is widely used for metastatic castrated resistant prostate cancer, but its efficacy is often compromised by drug resistance associated with low intracellular concentrations. Piperine (PIP) could enhance the bioavailability of other drugs via the inhibition of CYPs and P-gp activities. Thus, we hypothesize a positive effect with the DTX-PIP combination on the anti-tumor efficacy and intra-tumor DTX concentrations in taxane-resistant prostate cancer. ICR-NOD/SCID mice implanted with taxane-resistant human prostate cancer cells were administrated with saline as well as PIP and DTX separately or in combination. The tumor growth was monitored together with intra-tumor concentrations of DTX. The inhibitory effects on CYPs and P-gp were further assessed in mouse liver microsome and MDCK-MDR1 cells. Compared with DTX alone, DTX-PIP combination significantly inhibited the tumor growth (114% vs. 217%, p = 0.002) with corresponding significantly higher intra-tumor DTX concentrations (5.854 ± 5.510 ng/ml vs. 1.312 ± 0.754 ng/mg, p = 0.037). The percentage of DTX metabolism was significantly decreased from 28.94 ± 1.06% to 18.14 ± 2.22% in mouse liver microsome after administration of PIP for two weeks. DTX accumulation in MDCK-MDR1 cell was significantly enhanced in the presence of PIP. Further microarray analysis revealed that PIP inhibited P-gp as well as CYP1B1 gene expression and induced a significant gene expression change relating to inflammatory response, angiogenesis, cell proliferation, or cell migration. In conclusion, DTX-PIP combination significantly induces activity against taxane-resistant prostate tumor. Such effect appeared to be attributed to the inhibitory effect of PIP on CYPs and P-gp activity as well as gene expression changes relating to tumorigenesis and cellular responses.

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“…In addition to its function as spicy seasoning, pepper has also been valued as medicinal, preservative and perfumery ingredient and its pungent property is mainly attributed to PIP [2]. Recently, various beneficial effects of PIP have been revealed such as the anti-inflammation effect, immunomodulatory and anti-cancer activity, antispasmodic and anti-secretory effect [3][4][5][6]. Besides, PIP demonstrated significant neuroprotective effect for the treatment of Alzheimer's disease and Parkinson's disease [7,8].…”

Section: Introductionmentioning

confidence: 99%

Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats

Wang

Ren

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers

Cited by 28 publications

References 31 publications

Black pepper: Stimulation of diarrhea in patient with underlying short bowel syndrome

Black pepper: Stimulation of diarrhea in patient with underlying short bowel syndrome

Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination-in vitroandin vivoinvestigation using a taxane-resistant prostate cancer model

Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats

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