Inhibition of Interleukin-6 signaling: A novel therapeutic approach to necrotizing enterocolitis

Yarcı, Erbu; Tayman, Cüneyt; Yarci, Didem Ozturk; Çakır, Ufuk; Gönel, Ataman; Türkmenoğlu, Tuğba Taşkın

doi:10.1016/j.intimp.2021.108358

Cited by 6 publications

(12 citation statements)

References 33 publications

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“…Fecal filtrate transplantation (FFT) is effective in preventing NEC with no significant side effects [ 138 ] and amniotic fluid stem cell injection therapy prevented epithelial cell damage in necrotizing small bowel colitis [ 139 ]. Finally, tocilizumab inhibition of IL-6 may be a potential option for the treatment of NEC [ 140 ].…”

Section: Treatment Of Necmentioning

confidence: 99%

Necrotizing enterocolitis: current understanding of the prevention and management

Hu,

Liang,

et al. 2024

Pediatr Surg Int

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Necrotizing enterocolitis (NEC) is one of the diseases in neonates, with a high morbidity and mortality rate, especially in preterm infants. This review aimed to briefly introduce the latest epidemiology, susceptibility factors, and clinical diagnosis and presentation of NEC. We also organized new prevention strategies by risk factors according to different pathogeneses and then discussed new treatment methods based on Bell's staging and complications, and the classification of mild to high severity based on clinical and imaging manifestations. Such a generalization will help clinicians and researchers to gain a deeper understanding of the disease and to conduct more targeted classification, grading prevention, and exploration. We focused on prevention and treatment of the early and suspected stages of NEC, including the discovery of novel biomarkers and drugs to control disease progression. At the same time, we discussed its clinical application, future development, and shortcomings.

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Section: Treatment Of Necmentioning

confidence: 99%

Necrotizing enterocolitis: current understanding of the prevention and management

Hu,

Liang,

et al. 2024

Pediatr Surg Int

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“…Variations have been described modifying the factors that are considered to be etiopathogenic in NEC [ 29 , 30 ]: Hypoxia in % N 2 and O 2 , the number of times and the time it is induced (from 50s to 10 min). Other models even Re oxygenate after hypoxia [ 31 ]; Hypothermia (if done), at 4°C in combination with hypoxia or after hypoxia with a time of 3 to 10 min [ 24 – 30 , 32 – 37 ]; Administration (if any) of LPS (at doses of 1-20 mg/kg) [ 24 , 26 , 27 , 32 – 34 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The dose of CBD used in this model is 10 mg/kg and is injected only once after induction of NEC. The dose was selected based on our group's previous studies of neonatal hypoxic-ischaemic brain damage [ 1 – 5 , 25 , 36 , 37 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results show that, in the case of weight, the SHAM group increases moderately to almost 8 grams on the last feeding of the third day, i.e. corresponding to the weight of the usual control group [ 35 , 37 ]. However, the VEH and CBD groups decrease or maintain the newborn weight, between 4 and 5 grams, with no differences between them.…”

Section: Discussionmentioning

confidence: 99%

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Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis

Huertos Soto,

Gómez Cervantes,

Fernández Aceñero

et al. 2024

Lab Anim Res

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Background Necrotizing enterocolitis (NEC) is a severe inflammatory bowel disease in neonates. Our group has developed an experimental model of NEC, with an effectiveness of 73%. Cannabidiol (CBD) is an innovative treatment for neonatal cerebral hypoxic-ischemic pathologies due to its neuroprotective effect, as a potent anti-inflammatory and reducing oxidative stress substance. Our aim was to evaluate the effect of CBD on intestinal lesions in an experimental model of NEC. Results Mortality and intestinal histological damage was significantly lower in the CBD group compared to the rest (p<0.05), establishing CBD as a protective factor against the development of NEC (OR=0.0255; 95% CI=0.0015-0.4460). At IHQ level (TUNEL technique), a lower cell death rate was also observed in the CBD group compared to the VEH group (p<0.05). Conclusions In our experimental model, intraperitoneal CBD acts as a protective factor against NEC, resulting in less histological damage and a lower rate of intestinal cell death.

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“…Blocking TNF-α signaling by using an anti-TNF-α monoclonal antibody ( 143 ), pentoxifylline ( 144 ), etanercept ( 145 ), or infliximab ( 146 ) significantly alleviated intestinal inflammation and tissue damage in NEC neonatal rats. Tocilizumab, a humanized monoclonal antibody against IL-6 receptors, inhibits intestinal inflammation in NEC by blocking IL-6-mediated signal transduction ( 147 ). The fourth method involves blocking specific signaling pathways activated by Mφs.…”

Section: Therapeutic Application Of Imφs In Necmentioning

confidence: 99%

New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application

Wei,

Meng,

et al. 2023

Front. Immunol.

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Necrotizing enterocolitis (NEC) is an inflammatory intestinal disease that profoundly affects preterm infants. Currently, the pathogenesis of NEC remains controversial, resulting in limited treatment strategies. The preterm infants are thought to be susceptible to gut inflammatory disorders because of their immature immune system. In early life, intestinal macrophages (IMφs), crucial components of innate immunity, demonstrate functional plasticity and diversity in intestinal development, resistance to pathogens, maintenance of the intestinal barrier, and regulation of gut microbiota. When the stimulations of environmental, dietary, and bacterial factors interrupt the homeostatic processes of IMφs, they will lead to intestinal disease, such as NEC. This review focuses on the IMφs related pathogenesis in NEC, discusses the multi-functional roles and relevant molecular mechanisms of IMφs in preterm infants, and explores promising therapeutic application for NEC.

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Inhibition of Interleukin-6 signaling: A novel therapeutic approach to necrotizing enterocolitis

Cited by 6 publications

References 33 publications

Necrotizing enterocolitis: current understanding of the prevention and management

Necrotizing enterocolitis: current understanding of the prevention and management

Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis

New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application

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