New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application
Jiaqi Wei,
Zhaoli Meng,
Zhenyu Li
et al.
Abstract:Necrotizing enterocolitis (NEC) is an inflammatory intestinal disease that profoundly affects preterm infants. Currently, the pathogenesis of NEC remains controversial, resulting in limited treatment strategies. The preterm infants are thought to be susceptible to gut inflammatory disorders because of their immature immune system. In early life, intestinal macrophages (IMφs), crucial components of innate immunity, demonstrate functional plasticity and diversity in intestinal development, resistance to pathogen… Show more
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