Inhibition of intercellular communication by airborne particulate matter

Heussen, G.A.H.

doi:10.1007/bf02307317

Cited by 11 publications

(1 citation statement)

References 27 publications

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“…Combining these results with those of the genotoxicity assays, it can be concluded that nitrosated 4-chloroindoles should be considered as potential genotoxic agents and agents with potential tumor-promoting capacity. The capability to inhibit GJIC had previously been reported for only a few other genotoxic chemicals or mixture of chemicals such as dimethylbenzanthracene (Jongen et al, 1987), cigarette smoke condensate (Jongen et al, 1985), and airborne particulate matter (Heussen, 1991).…”

Section: Discussionmentioning

confidence: 99%

In vitro testing and the carcinogenic potential of several nitrosated indole compounds

et al. 1991

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4-chloro-methoxyindole is a naturally occurring compound in Vicia faba which can easily react with nitrite to form a N-nitroso compound. In this in vitro study, the potential genotoxic effects of nitrosated 4-chloro-6-methoxyindole and its structural analogue 4-chloroindole were evaluated for the first time by using both Salmonella and Chinese hamster V79 cells. Additionally, the inhibition of gap junctional intercellular communication in V79 cells by these compounds was determined; this is a validated parameter for tumor-promoting activity. Most assays were also performed with nitrosated indole-3-acetonitrile, a naturally occurring compound in brassicas. Both nitrosated chloroindoles were highly mutagenic to Salmonella typhimurium TA100 without the need of exogenous metabolic activation and were potent inducers of Sister Chromatid Exchanges. Nitrosated indole-3-acetonitrile generated the same effects, although at much higher concentrations. Equivocal results were obtained for the nitrosated chloroindoles in a forward mutation assay using the hypoxanthine guaninephosphoribosyltransferase locus. All nitrosated indole compounds significantly inhibited gap junctional intercellular communication. These results indicate that nitrosated chloroindoles and nitrosated indole-3-acetonitrile should be considered as mutagens and agents with potential tumor-promoting capacity.

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Section: Discussionmentioning

confidence: 99%

In vitro testing and the carcinogenic potential of several nitrosated indole compounds

et al. 1991

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Use of Biochemical and Molecular Biomarkers for Cancer Risk Assessment in Humans

Amaral-Mendes

Pluygers

1999

Perspectives on Biologically Based Cancer Risk Assessment

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Inhibition of binding of thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats

Heussen

Hikspoors

Spenkelink

et al. 1992

Arch. Environ. Contam. Toxicol.

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Previous studies have indicated that chemicals, e.g., hydroxylated polychlorinated biphenyls (PCBs) decrease plasma thyroxin levels through interaction with transthyretin. As a consequence, plasma vitamin A and thyroxin are depleted. Both thyroxin and vitamin A are important regulators of normal epithelial differentiation and proliferation and might act in the promotion phase of carcinogenesis. In the present report, extracts of indoor and outdoor airborne particulate matter (APM), originating from different pollution sources, were tested for a possible interaction in vitro and in vivo with thyroxin and vitamin A. Results indicated that all APM extracts significantly interfered with thyroxin binding to transthyretin. In all cases, the more polluted samples inhibited binding more than the corresponding control samples. Exposure of rats to a cigarette smoke extract induced clear changes in plasma thyroxin and triiodothyronin hormone levels. Triiodothyronin levels were reduced most. Effects on plasma vitamin A levels were also found, but these were less clear. In addition a decrease in lung vitamin A levels was found, but this decrease was not statistically significant. Exposure of rats to an outdoor APM extract induced significant changes in plasma triiodothyronin levels. Effects on thyroxin levels were not significant, although the same trend was seen as for the cigarette smoke APM extract. No changes in plasma or liver vitamin A concentrations were induced by the outdoor APM extract. Lung vitamin A levels were decreased, but again this decrease was not statistically significant. Taken together, the present report shows that APM extracts have the potency to interfere with thyroid hormone metabolism both in vitro and in vivo and probably with vitamin A metabolism as well.(ABSTRACT TRUNCATED AT 250 WORDS)

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Inhibition of intercellular communication by airborne particulate matter

Cited by 11 publications

References 27 publications

In vitro testing and the carcinogenic potential of several nitrosated indole compounds

In vitro testing and the carcinogenic potential of several nitrosated indole compounds

Use of Biochemical and Molecular Biomarkers for Cancer Risk Assessment in Humans

Inhibition of binding of thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats

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