Use of Biochemical and Molecular Biomarkers for Cancer Risk Assessment in Humans

Amaral-Mendes, J. J.; Pluygers, E

doi:10.1007/978-1-4615-4741-9_4

Cited by 4 publications

(1 citation statement)

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“…Biomarkers of susceptibility are indicators of an inherent or acquired limitation of an organism's ability to respond to the challenge of exposure to a specific xenobiotic substance (25). Examples include interindividual differences in metabolism (activation and detoxification) of carcinogenic chemicals, DNA repair, and the functions of proto-oncogenes or tumor suppressor genes, as well as interindividual differences in nutritional, hormonal, and immunologic factors (26).…”

Section: Introductionmentioning

confidence: 99%

Interindividual Variability in Response to Sodium Dichromate–Induced Oxidative DNA Damage: Role of the Ser326Cys Polymorphism in the DNA-Repair Protein of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine DNA Glycosylase 1

Lee

Hodges

Chipman

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although the genotoxic mechanism(s) of hexavalent chromium (CrVI) carcinogenicity remain to be fully elucidated, intracellular reduction of CrVI and concomitant generation of reactive intermediates including reactive oxygen species and subsequent oxidative damage to DNA is believed to contribute to the process of carcinogenesis. In the current study, substantial interindividual variation (7.19-25.84% and 8.79-34.72% tail DNA as assessed by conventional and FPGmodified comet assay, respectively) in levels of DNA strand breaks after in vitro treatment of WBC with sodium dichromate (100 Amol/L, 1 hour) was shown within a group of healthy adult volunteers (n = 72) as assessed by both comet and formamidopyrimidine glycosylase -modified comet assays. No statistically significant correlation between glutathione S-transferases M1 or T1, NADPH quinone oxidoreductase 1 (codon 187) and X-ray repair cross complementation factor 1 (codon 194) genotypes and individual levels of DNA damage were observed.

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Section: Introductionmentioning

confidence: 99%