Inhibition of influenza A virus sialidase activity by sulfatide

Suzuki, Takashi; Takahashi, Toshifumi; Nishinaka, Daisuke; Murakami, Masanori; Fujii, Satoshi; Hidari, Kazuya I.P.J.; Miyamoto, Daisei; Li, Yu-Teh; Suzuki, Yasuo

doi:10.1016/s0014-5793(03)01045-7

Cited by 21 publications

(16 citation statements)

References 30 publications

(32 reference statements)

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“…97) Sulfatide also strongly inhibits the sialidase activities of influenza A viruses in a pH-dependent manner, non-competitively. 98) Influenza virus infection of desialylated cells 99) and involvement of the mannose receptor in infection of macrophages by influenza virus 100) have also been reported.…”

Section: )mentioning

confidence: 98%

Sialobiology of Influenza: Molecular Mechanism of Host Range Variation of Influenza Viruses

Suzuki

2005

Biological & Pharmaceutical Bulletin

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382

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The gene pool of influenza A viruses in aquatic birds provides all of the genetic diversity required for human and lower animals. Host range selection of the receptor binding specificity of the influenza virus hemagglutinin occurs during maintenance of the virus in different host cells that express different receptor sialo-sugar chains. In this paper, functional roles of the hemagglutinin and neuraminidase spikes of influenza viruses are described in the relation to 1) host range of influenza viruses, 2) receptor binding specificity of human and other animal influenza viruses, 3) recognition of sialyl sugar chains by Spanish influenza virus hemagglutinin, 4) highly pathogenic and potentially pandemic H5N1, H9N2, and H7N7 avian influenza viruses and molecular mechanism of host range variation of influenza viruses, 5) role of the neuraminidase spike for the host range of influenza viruses, and 6) Development of anti-influenza drugs.

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Section: )mentioning

confidence: 98%

Sialobiology of Influenza: Molecular Mechanism of Host Range Variation of Influenza Viruses

Suzuki

2005

Biological & Pharmaceutical Bulletin

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382

333

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“…Association of sulfatide with HA delivered to the cell surface induces translocation of newly synthesized NP from nucleus to cytoplasm. We previously found that sulfatide bound to IAV particles and inhibited viral infection and also inhibited viral sialidase activity under low-pH conditions (36,38). Influenza virus HA and NA are known to cluster in lipid rafts for assembly and budding of IAV (31,44).…”

Section: Resultsmentioning

confidence: 99%

“…We previously found that sulfatide binds to IAV particles and inhibits viral infection and sialidase activity under low-pH conditions (36,38); however, the role of sulfatide in IAV infection remains unknown. In the present study, we investigated the function of sulfatide in the virus infection cycle by knockdown of sulfatide expression in Madin-Darby canine kidney (MDCK) cells, which are known to adequately support IAV replication, and by genetic up-regulation of sulfatide expression in COS-7 cells, which lack sulfatide expression and sufficient IAV replication.…”

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confidence: 99%

Sulfatide Is Required for Efficient Replication of Influenza A Virus

Takahashi

Murakami

Nagakura

et al. 2008

J Virol

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“…We had found that IAV strongly binds to sulfatide, which has no sialic acid ( 156 ), and that sulfatide inhibits IAV sialidase activity under an acidic condition but not under a neutral condition ( 157 ). We have tried to elucidate the role of sulfatide in the IAV infection cycle.…”

Section: Infl Uenza a Virusmentioning

confidence: 99%