Role of sulfatide in normal and pathological cells and tissues

Takahashi, Toshifumi; Suzuki, Takashi

doi:10.1194/jlr.r026682

Cited by 244 publications

(249 citation statements)

References 155 publications

(127 reference statements)

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“…Several studies have proposed the biological functions of sulfatides in various fields, including the nervous system, immune system, glucose metabolism, osmotic regulation, spermatogenesis, thrombosis/hemostasis, microbial infection, and cancer [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, sulfatide metabolism dysfunction might lead to the development of various diseases [2]. The multifunctional property of sulfatides is thought to be associated with the diversity of their chemical structures.…”

Section: Introductionmentioning

confidence: 99%

“…The multifunctional property of sulfatides is thought to be associated with the diversity of their chemical structures. Depending on the ceramide moiety, various molecular species of sulfatides exist, whose expression pattern and level are specific in tissues [1,2]. Therefore, understanding the regulatory mechanism of sulfatide metabolism in various tissues may be important.…”

Section: Introductionmentioning

confidence: 99%

“…This reaction is catalyzed only by cerebroside sulfotransferase (CST) [3]. In contrast, sulfatides are degraded in this reverse reaction that is catalyzed by arylsulfatase A (ARSA) [1,2]. However, there is little information about the transcriptional regulators for these key enzymes in sulfatide metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs

et al. 2012

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Sulfatides, 3-O-sulfogalactosylceramides, are known to have multifunctional properties. These molecules are distributed in various tissues of mammals, where they are synthesized from galactosylceramides by sulfation at C3 of the galactosyl residue.Although this reaction is specifically catalyzed by cerebroside sulfotransferase (CST), the mechanisms underlying the transcriptional regulation of this enzyme are not understood. With respect to this issue, we previously found potential sequences of peroxisome proliferator-activated receptor (PPAR) response element on upstream regions of the mouse CST gene and presumed the possible regulation by the nuclear receptor PPARα. To confirm this hypothesis, we treated wild-type and Ppara-null mice with the specific PPARα agonist fenofibrate and examined the amounts of sulfatides and CST gene expression in various tissues. Fenofibrate treatment increased sulfatides and CST mRNA levels in the kidney, heart, liver, and small intestine in a PPARα-dependent manner. However, these effects of fenofibrate were absent in the brain or colon.Fenofibrate treatment did not affect the mRNA level of arylsulfatase A, which is the key enzyme for catalyzing desulfation of sulfatides, in any of these six tissues. Analyses of the DNA-binding activity and conventional gene expression targets of PPARα has demonstrated that fenofibrate treatment activated PPARα in the kidney, heart, liver, and 4 small intestine but did not affect the brain or colon. These findings suggest that PPARα activation induces CST gene expression and enhances sulfatide synthesis in mice, which suggests that PPARα is a possible transcriptional regulator for the mouse CST gene.(less than 250 words)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs

et al. 2012

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“…23) Sulfatide has been reported to be involved in many biological activities including the nervous system, cancer, insulin secretion in the islet of Langerhans, hemostasis/thrombosis, immune system, and microbial infection. 24) For viruses other than influenza A virus, roles of sulfatide have been shown or suggested in infection and replication of human immunodeficiency virus-1 (HIV-1), [25][26][27][28][29][30][31] Vaccinia virus, 32) hepatitis C virus, 33) and human parainfluenza virus type 3.…”

Section: )mentioning

confidence: 99%