2019
DOI: 10.1002/jcb.28476
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Inhibition of indoleamine 2,3‐dioxygenase attenuates endotoxin‐mediated tolerance in granulosa cells through kynurenine pathway

Abstract: Ovarian granulosa cells (GCs) have been shown to have innate immune capabilities, which modulate their native endocrine functions through toll-like receptors (TLRs). We have recently shown that GCs exposed to lipopolysaccharide (LPS; 1.0 µg/mL) transiently regulate proinflammatory cytokine expression (interleukin 1β [IL-1β], IL-6, and tumor necrosis factor α) through chromatin remodeling. In the present study, we have demonstrated that GCs become tolerant to LPS on repeated exposure of LPS. To understand the m… Show more

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Cited by 2 publications
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