Inhibition of hsa_circ_0002570 suppresses high-glucose–induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-1243/angiomotin axis

Liu, Guodan; Zhou, Shifeng; Li, Xinge; Ding, Xing; Tian, Miao

doi:10.1007/s12192-020-01111-2

Cited by 27 publications

(14 citation statements)

References 26 publications

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“…Circular RNA-0002570 (circ-0002570) was a newly identified circRNA. Recently, Liu and his group firstly identified circ-0002570 as a diabetic retinopathy-related circRNA that can sponge miR-1243 ( 13 ). However, whether circ-0002570 was dysregulated in tumors, and its potential function have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer

et al. 2021

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BackgroundCircular RNAs (circRNAs) are closely associated with the occurrences and progress of gastric cancer (GC). We aimed to delve into the function and pathological mechanism of Circular RNA-0002570 (circ-0002570) in GC progression.MethodsCircRNAs differentially expressed in GC were screened using bioinformatics technology. The expression of circ-0002570 was detected in GC specimens and cells via qRT-PCR, and the prognostic values of circ-0002570 were determined. The functional roles of circ-0002570 on proliferation, migration, and invasion in GC cells were explored in vitro and in vivo. Interaction of circ-0002570, miR-587, and VCAN was confirmed by dual-luciferase reporter assays, Western blotting, and rescue experiments.ResultsCirc-0002570 expression was distinctly increased in GC tissues compared to adjacent normal specimens, and GC patients with higher circ-0002570 expressions displayed a short survival. Functionally, knockdown of circ-0002570 resulted in the inhibition of cell proliferation, migration, and invasion, and suppressed tumor growth in vivo. Mechanistically, miR-587 was sponged by circ-0002570. VCAN expression in NSCLC was directly inhibited by miR-587. Overexpression of circ-0002570 prevented VCAN from miR-587-mediated degradation and thus facilitated GC progression.ConclusionThe circ-0002570-miR-587-VCAN regulatory pathway promoted the progression of GC. Our findings provided potential new targets for the diagnosis and therapy of GC.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer

et al. 2021

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“…As previously reported, miR-1243 could also directly bind with hsa_circ_0002570 and angiomotin mRNA, and miR-1243 and hsa_circ_0002570 are mutual inhibitors of each other; moreover, the knockdown of hsa_circ_0002570 inhibited proliferation, migration, tube formation, and the release of pro-inflammatory cytokines induced by hyperglycemia in hRECs (12). In this work, the direct interaction between RELB mRNA/circ_0008590 and miR-1243 was confirmed, suggesting that miR-1243 may be a key molecule in hRECs in DR, and that miR-1243 may be part of the self-protection mechanism during the development of DR through its effect on multiple signaling pathways.…”

Section: Discussionsupporting

confidence: 65%

“…It has been reported that circular RNAs (circRNAs) can act as sponges for microRNAs (miRNAs) (10)(11)(12). In recent years, the number of studies of circRNAs in the field of DR has increased considerably: for example, circRNAs have been screened as potential biomarkers for DR (13); miR-1243 was shown to repress angiogenesis and inflammation in human retinal microvascular endothelial cells (hRECs) grown in a high-glucose environment by inhibiting hsa_circ_0002570 (12); circRNA COL1A2 promotes angiogenesis in DR (14); hsa_circ_0041795 induces ARPE-19 cell damage in a high-glucose environment by interacting with miR-646 (15); circRNA cPWWP2A promotes the DR-induced retinal vasculature by interacting with miR-579 (16), similar to other circRNAs, including circDNMT3B, circHIPK3, and circ_0005015 (17).…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia-induced increasing of RELB/circ_0008590 in NF-κB pathway is repressed by miR-1243 in human retinal microvascular endothelial cells

Shao¹,

Cai²,

Yao³

et al. 2021

Ann Transl Med

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“…Ji and Wei et al reported that hsa_circ_0091581 is involved in hepatocellular carcinoma progression by sponging miR-591 and miR-526b [28,29]. In the present study, hsa_circ_0091581 was able to sponge miR-1243-5p involved in the progression of pancreatic cancer as a target of hsa_circ_0002570 [36]. Then, a search of an online database and luciferase reporter assays were used to select RecQ-mediated genome instability protein 1 (RMI1) as the target of miR-1243-5p.…”

Section: Discussionsupporting

confidence: 58%

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p

Qian

et al. 2021

J. Cancer

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Glioma is a pervasive malignancy and the main cause of cancer-related deaths worldwide. Circular RNA is an important subject of cancer research, and its role and function in glioma are poorly understood. This study demonstrated that hsa_circ_0091581 is upregulated in glioma tissues and cells. The results of the CCK-8, EdU, and transwell assays indicated that hsa_circ_0091581 promotes proliferation, migration, and invasion of glioma cells. The results of the luciferase reporter and RNA immunoprecipitation assays indicated that the mechanism of the effects of hsa_circ_0091581 on glioma cells involves sponging miR-1243-5p to regulate RMI1. The results of the rescue experiments indicated that hsa_circ_0091581 regulates proliferation, migration, and invasion of glioma cells by targeting RMI1 in a miR-1243-5p dependent manner. The results of the nude mice xenograft assays showed that knockdown of hsa_circ_0091581 inhibits glioma growth in vivo. Thus, our study determined the role of hsa_circ_0091581/miR-1243-5p/RMI1 in glioma and suggests that this axis may be a novel therapeutic target in glioma.

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Inhibition of hsa_circ_0002570 suppresses high-glucose–induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-1243/angiomotin axis

Cited by 27 publications

References 26 publications

RETRACTED: Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer

RETRACTED: Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer

Hyperglycemia-induced increasing of RELB/circ_0008590 in NF-κB pathway is repressed by miR-1243 in human retinal microvascular endothelial cells

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p

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