Inhibition of Herpes Simplex Virus by Polyamines

Yudovin-Farber, Ira; Gurt, Irina; Hope, Ronen; Domb, Abraham J.; Katz, Ehud

doi:10.3851/imp1401

Cited by 10 publications

(6 citation statements)

References 34 publications

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“…For this reason, QSARs are strongly related with Bioinformatics, because this science entails the creation and advancement of databases, algorithms, computational and statistical techniques and theory to solve formal and practical problems arising from the management and analysis of biological data. In the last 20 years, some QSAR studies have been reported for the design of anti-herpes agents ( Table 2), with the objective to find more potent and versatile compounds with anti-viral activity against herpes viruses, principally HVS-1 and HVS-2 [43][44][45][46][47][48][49][50], and with the use of statistical methods such as multiple linear regression (MLR) and partial least squares (PLS).…”

Section: Qsar Methodologiesmentioning

confidence: 99%

“…In order to perform a rigorous design, only 255 compounds were considered active as herpes viruses DNA-polymerase and/or protease inhibitors [134], according to the biological criterias, which were characteristics of each protein ( Table 5). As measure of biological activity, the enzymatic potency was selected and expressed as IC 50 , i.e., the concentration of the compound that resulted in the diminution of the 50% of the enzymatic activity.…”

Section: Selection Of the Data Set: Calculation Of The Descriptors Anmentioning

confidence: 99%

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Application of Bioinformatics for the Search of Novel Anti-Viral Therapies: Rational Design of Anti-Herpes Agents

Cordeiro¹

2011

CBIO

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Human herpes viruses (HHV) are leading cause of human viral diseases, second after influenza and cold viruses. They cause overt disease or can remain silent for many years waiting for reactivation. HHV are associated to several side-effects or co-conditions like Alzheimer's disease, cholangiocarcinoma and pancreatic cancer, and with the time, they have become resistant to the available commercial drugs like acyclovir, whose final target is the DNApolymerase. For this reason there is an increasing interest for the search of novel compounds against herpes viruses. In this sense, Bioinformatics is determinant for a better understanding of the mechanisms of resistance, and also for the search of new biomolecular targets for the design of more potent and versatile anti-herpes agents. This review is focused on the role of Bioinformatics toward the design of compounds with anti-herpetic activity and also we propose a model based fragment descriptors for the design, search and prediction of anti-herpes compounds through the inhibition of 5 targets belonging to different herpes viruses.

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Section: Qsar Methodologiesmentioning

confidence: 99%

Section: Selection Of the Data Set: Calculation Of The Descriptors Anmentioning

confidence: 99%

Application of Bioinformatics for the Search of Novel Anti-Viral Therapies: Rational Design of Anti-Herpes Agents

Cordeiro¹

2011

CBIO

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“…Other polymers have been synthesized that do not require sulfate groups to effectively inhibit HSV infection. Polymers with a polycationic character have been widely studied in the field: polylysine, polyarginine, polyacrylates, viologen (4,4′-bipyridinium salts) dendrimers, polyethylenimine, poly(amidoamine)s, poly(ethylene glycol)- block -poly(3-(methacryloylamino)propyl trimethylammonium chloride), and oligoamines conjugated to dextran as well as other cationic dextran derivatives. ,− Possible mechanisms of action include destabilizing cell membranes, electrostatically interacting with the envelope of lipid-enveloped viruses, or inhibiting virus–cell surface interactions by binding to negatively charged cell surface heparan sulfate. ,, In some instances, such as AGMA1 poly(amidoamine)s or Eudragit E100, these polymers could potentially be applied as microbicides. , …”

Section: Herpes Simplex Virusmentioning

confidence: 99%

Antiviral Polymers: Past Approaches and Future Possibilities

2020

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Treating a viral disease is no simple feat. Drug resistance, latent reservoirs in the body, emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral therapy. For decades, antiviral polymers have been studied for a range of infectious diseases. The field has emerged, expanded, and adapted over the past 70 years, producing unique classes of materials that hold promise for overcoming these obstacles. Antiviral polymers can directly inhibit viral replication and infection, usually by binding to the virus and preventing it from invading a host cell. They can also serve as microbicides or antiviral drug-delivery vehicles. This Perspective outlines the significant advances and challenges in the field. We discuss polymers with activity against viruses with limited treatment options (hepatitis C), ubiquitous presence (influenza, norovirus), or long-term complications (HIV). We also explore insights into different mechanisms of action, and we offer ideas on how the field of antiviral polymers might advance in the future.

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“…In vitro assays showed dextran‐propan‐1,3‐diamine to be the most potent inhibitor of HSV entry, probably via its interaction with cell receptors. [ 264 ] PEI‐based compounds comprise a class of polycationic antivirals. Unmodified PEI functions in inhibiting the entry of HPV and cytomegalovirus (HCMV) and electrostatically blocking HS cell receptors in vitro.…”

Section: Polymers Against Virusesmentioning

confidence: 99%

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Rodrigues

Campo

Arns

et al. 2021

Part & Part Syst Charact

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Infectious diseases caused by viruses are a global health concern and have become prominent in light of the recent COVID‐19 pandemic. Considering the limitations of drugs and prophylactic methods used in current medicine, antiviral materials are a useful strategy in preventing the spread of viruses and enhancing treatment efficiency. Thus, this review highlights the state‐of‐the‐art antiviral materials, describes the scientific landscape of the primary antiviral materials used based on bibliometric analysis, presents their mechanisms of action, and discusses their clinical applications. The mechanisms of action underlying the broad‐spectrum antiviral properties of metals, ceramics, polymers, and composites are also discussed. Polyanions, polycations, oxides, and metal‐based materials, from bulk to nanoparticles, have good potential in antiviral applications that may help prepare the world for future viral breakouts.

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Inhibition of Herpes Simplex Virus by Polyamines

Abstract: Our in vitro data warrant clinical investigation. DPD could have an advantage as a topical application in combination therapy of HSV lesions.

Cited by 10 publications

References 34 publications

Application of Bioinformatics for the Search of Novel Anti-Viral Therapies: Rational Design of Anti-Herpes Agents

Application of Bioinformatics for the Search of Novel Anti-Viral Therapies: Rational Design of Anti-Herpes Agents

Antiviral Polymers: Past Approaches and Future Possibilities

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

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