Inhibition of Glutamine Cellular Uptake Contributes to the Cytotoxic Effect of Xanthohumol in Triple-Negative Breast Cancer Cells

Carmo, F; Silva, C; Martel, Fátima

doi:10.1080/01635581.2022.2076889

Cited by 6 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study found EGCG effectively reduced total and sodium-dependent glutamine uptake in tumor cells ( 197 ). Unfortunately, it is unclear from current studies whether this suppression is related to the expression levels and transport activities of glutamine transporters including alanine/serine/cysteine transporter 2 (ASCT2), and sodium-coupled neutral amino acid transporter 1 and 2 (SNAT1, SNAT2), although these glutamine transporters are often upregulated in tumors.…”

Section: Regulatory Roles In Tumor Metabolic Reprogrammingmentioning

confidence: 99%

The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

Li,

Cao,

Sun

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Cancer, a disease that modern medicine has not fully understood and conquered, with its high incidence and mortality, deprives countless patients of health and even life. According to global cancer statistics, there were an estimated 19.3 million new cancer cases and nearly 10 million cancer deaths in 2020, with the age-standardized incidence and mortality rates of 201.0 and 100.7 per 100,000, respectively. Although remarkable advancements have been made in therapeutic strategies recently, the overall prognosis of cancer patients remains not optimistic. Consequently, there are still many severe challenges to be faced and difficult problems to be solved in cancer therapy today. Epigallocatechin gallate (EGCG), a natural polyphenol extracted from tea leaves, has received much attention for its antitumor effects. Accumulating investigations have confirmed that EGCG can inhibit tumorigenesis and progression by triggering apoptosis, suppressing proliferation, invasion, and migration, altering tumor epigenetic modification, and overcoming chemotherapy resistance. Nevertheless, its regulatory roles and biomolecular mechanisms in the immune microenvironment, metabolic microenvironment, and immunotherapy remain obscure. In this article, we summarized the most recent updates about the effects of EGCG on tumor microenvironment (TME), metabolic reprogramming, and anti-cancer immunotherapy. The results demonstrated EGCG can promote the anti-cancer immune response of cytotoxic lymphocytes and dendritic cells (DCs), attenuate the immunosuppression of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), and inhibit the tumor-promoting functions of tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and various stromal cells including cancer-associated fibroblasts (CAFs), endothelial cells (ECs), stellate cells, and mesenchymal stem/stromal cells (MSCs). Additionally, EGCG can suppress multiple metabolic reprogramming pathways, including glucose uptake, aerobic glycolysis, glutamine metabolism, fatty acid anabolism, and nucleotide synthesis. Finally, EGCG, as an immunomodulator and immune checkpoint blockade, can enhance immunotherapeutic efficacy and may be a promising candidate for antitumor immunotherapy. In conclusion, EGCG plays versatile regulatory roles in TME and metabolic reprogramming, which provides novel insights and combined therapeutic strategies for cancer immunotherapy.

show abstract

Section: Regulatory Roles In Tumor Metabolic Reprogrammingmentioning

confidence: 99%

The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

Li,

Cao,

Sun

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Through proteomic analysis, SLC1A5 has been identified as an independent prognostic factor for breast cancer. Therefore, targeting Gln uptake by SLC1A5 may be a potential therapeutic strategy for TNBC 57,58 …”

Section: Amino Acid Transporters In Breast Cancermentioning

confidence: 99%

Amino acids and their roles in tumor immunotherapy of breast cancer

Xia,

Zhu,

Zheng

et al. 2023

The Journal of Gene Medicine

View full text Add to dashboard Cite

Breast cancer is the most commonly diagnosed cancer among women. The primary treatment options include surgery, radiotherapy, chemotherapy, targeted therapy and hormone therapy. The effectiveness of breast cancer therapy varies depending on the stage and aggressiveness of the cancer, as well as individual factors. Advances in early detection and improved treatments have significantly increased survival rates for breast cancer patients. Nevertheless, specific subtypes of breast cancer, particularly triple‐negative breast cancer, still lack effective treatment strategies. Thus, novel and effective therapeutic targets for breast cancer need to be explored. As substrates of protein synthesis, amino acids are important sources of energy and nutrition, only secondly to glucose. The rich supply of amino acids enables the tumor to maintain its proliferative competence through participation in energy generation, nucleoside synthesis and maintenance of cellular redox balance. Amino acids also play an important role in immune‐suppressive microenvironment formation. Thus, the biological effects of amino acids may change unexpectedly in tumor‐specific or oncogene‐dependent manners. In recent years, there has been significant progress in the study of amino acid metabolism, particularly in their potential application as therapeutic targets in breast cancer. In this review, we provide an update on amino acid metabolism and discuss the therapeutic implications of amino acids in breast cancer.

show abstract

“…By increasing p53-upregulated modulator of apoptosis (PUMA)-mediated apoptosis, it also inhibits non-small cell lung cancer ( Li et al, 2022d ). It hampers glutamine uptake in triple negative breast cancer ( Carmo et al, 2022 ). It also inhibits a variety of cancers as prostate, B-chronic lymphocytic leukemia, hepatocellular, and medullary thyroid cancers ( Lust et al, 2005 ; Szliszka et al, 2009 ; Cook et al, 2010 ; Dorn et al, 2010 ).…”

Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.

show abstract

Inhibition of Glutamine Cellular Uptake Contributes to the Cytotoxic Effect of Xanthohumol in Triple-Negative Breast Cancer Cells

Cited by 6 publications

References 59 publications

The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

Amino acids and their roles in tumor immunotherapy of breast cancer

The therapeutic potential of natural products for treating pancreatic cancer

Contact Info

Product

Resources

About