2007
DOI: 10.1016/j.intimp.2006.03.018
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Inhibition of gene expression and production of iNOS and TNF-α in LPS-stimulated microglia by methanol extract of Phellodendri cortex

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Cited by 40 publications
(24 citation statements)
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References 21 publications
(33 reference statements)
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“…Previous pharmacological and phytochemical studies about this herb mainly focused on the quaternary isoquinoline alkaloids (e.g. berberine and palmatine) (Ma et al, 2008;Wu et al, 2005;Mitani et al, 2001;Park et al, 2007), while little attention was paid to the phenols and other compounds (Yoshiteru et al, 1994). Several analytical methods, e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Previous pharmacological and phytochemical studies about this herb mainly focused on the quaternary isoquinoline alkaloids (e.g. berberine and palmatine) (Ma et al, 2008;Wu et al, 2005;Mitani et al, 2001;Park et al, 2007), while little attention was paid to the phenols and other compounds (Yoshiteru et al, 1994). Several analytical methods, e.g.…”
Section: Introductionmentioning
confidence: 99%
“…Previous microglia isolation approaches have led to enriched microglia cultures from whole brain (Giulian and Baker, 1986;Floden and Combs, 2007;Park et al, 2007;Wang et al, 2007); hippocampus (Frank et al, 2006); cerebral cortices (Saura et al, 2003;Min et al, 2006); forebrain (Milner and Campbell, 2002;Majed et al, 2006); subcortical white matter (de Groot et al, 2001;Dalmau et al, 2003); corpus callosum; and prefrontal, temporal, and occipital cortex (de Groot et al, 2001).…”
mentioning
confidence: 99%
“…Recently, several studies have shown that PCE had a protective role against ischemia-reperfusioninduced brain injury through the reduction of neutrophil infiltration into the brain (Hwang et al 2002b). It also alleviated LPS-stimulated inflammatory responses, including LPS-induced expression of TNF-a, IL-1b, and iNOS through the negative modulation of nuclear factor-kappaB (NF-kB) signaling in the microglial cells (Park et al 2007). Thus, these studies suggest a new medicinal role of PCE on suppressing inflammatory response in the central nervous system, which can lead to developing a novel therapeutics using PCE for treating neurodegenerative diseases in humans.…”
Section: Discussionmentioning
confidence: 99%
“…Some studies have demonstrated that PCE alleviated LPS-induced acute airway inflammation through decreasing the infiltration of inflammatory cells and releasing inflammatory mediators (Mao et al 2010). It also attenuated LPSinduced inflammatory responses and inhibited the expression of TNF-a, IL-1b, and nitric oxide mRNAs in BV2 mouse microglia cells (Park et al 2007). These studies suggest that PCE could be useful for suppressing inflammation in neurodegenerative diseases.…”
Section: Introductionmentioning
confidence: 99%