Inhibition of Fibroblast Growth Factor Receptor Attenuates UVB-Induced Skin Carcinogenesis

Thakur, Megha; Khandelwal, Alok R.; Gu, Xia; Rho, Okkyung; Carbajal, Steve; Kandula, Rima A.; DiGiovanni, John; Nathan, Cherie‐Ann

doi:10.1016/j.jid.2022.03.036

Cited by 5 publications

(4 citation statements)

References 51 publications

(63 reference statements)

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“…The two types of skin aging are chronologic aging (intrinsic or endogenous) and exogenous aging (photoaging). While chronologic aging, due to the passage of time, is mainly accompanied by the progressive deterioration of the structure and function of the skin, environmental factors such as long-term exposure to sunlight (UV radiation) are responsible for photoaging wherein skin texture changes ( Alencar-Silva et al, 2018 , Espinosa-Leal and Garcia-Lara, 2019 , Gruber et al, 2019 , Lee et al, 2019 , Mukherjee et al, 2011 , Park et al, 2018 , Thakur et al, 2022 ). The two main deleterious types of UV are UV-A and UB-B with the spectrum in the range of 320–400 nm and 290–320 nm, respectively ( Fig.…”

Section: Antioxidants Free Radicals Inflammation and Skincarementioning

confidence: 99%

“…Other common consequences of acute and chronic sun exposure are DAMP generation, changes in skin pigmentation as well as photo-induced skin cancer. The deleterious effects of sun rays on the skin are mainly due to its ultraviolet rays ( Madan and Nanda, 2018 , Seok et al, 2016 , Thakur et al, 2022 ). On the other hand, intrinsic/age-dependent aging is mainly due to conditions such as hormonal changes, telomere shortening, as well as an imbalance between free radicals and antioxidants.…”

Section: Antioxidants Free Radicals Inflammation and Skincarementioning

confidence: 99%

See 1 more Smart Citation

Trends and challenges in phytotherapy and phytocosmetics for skin aging

Ahmed

Mikail²,

Zamakshshari³

et al. 2022

Saudi Journal of Biological Sciences

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Section: Antioxidants Free Radicals Inflammation and Skincarementioning

confidence: 99%

Section: Antioxidants Free Radicals Inflammation and Skincarementioning

confidence: 99%

Trends and challenges in phytotherapy and phytocosmetics for skin aging

Ahmed

Mikail²,

Zamakshshari³

et al. 2022

Saudi Journal of Biological Sciences

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“…Recently, a study by Thakur et al demonstrated that the fibroblast growth factor receptor (FGFR) is strongly involved in UVB-induced skin carcinogenesis and its inhibition may prevent cSCC development. 77 Prior in vitro experiments by Zhu et al in gastric cancer showed that FGFR2 expression is regulated by Twist1, and both are upregulated in more aggressive and poorly differentiated cells. 78 Interestingly, siRNA knockdown of FGFR2 attenuated Twist1induced cell invasion but not proliferation.…”

Section: Regulation Of Twist1mentioning

confidence: 99%

Twist1 as a target for prevention of cutaneous squamous cell carcinoma

Wang

Rho

Eguiarte-Solomon³

et al. 2022

Molecular Carcinogenesis

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Cutaneous squamous cell carcinoma (cSCC) represents an important clinical problem requiring novel approaches for both prevention and treatment. The transcription factor, Twist-related protein 1 (Twist1), has been identified as having a key mechanistic role in the development and progression of cSCC. Studies in relevant mouse models of cSCC have shown that Twist1 regulates epithelial-mesenchymal transition (EMT) and stemness driving progression and metastasis of cSCC. In addition, further research has shown that Twist1 regulates the balance between keratinocyte proliferation and differentiation and therefore impacts earlier stages of cSCC development. Through use of keratinocyte specific Twist1 knockout models, a role for this gene in keratinocyte stem cell homeostasis has been revealed. As a transcription factor, Twist1 regulates a large number of genes both in a positive, as well as a negative manner across several interdependent pathways. Studies in keratinocyte specific knockout models have shown that Twist1 upregulates the expression of genes involved in proliferation, stemness, and EMT while downregulating the expression of genes associated with differentiation. Furthermore, a number of compounds, including naturally occurring compounds, have been identified that target Twist1 and can block its effects in cancer cells and in keratinocytes in vivo. Collectively, the current understanding of Twist1 function in cSCC development and progression suggests that it represents a potential target for prevention and treatment of cSCC.

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“…However, UVA radiation is much less photochemically active and not strongly absorbed by proteins and nucleic acids, so it is generally less harmful than UVB radiation (2,3). In humans, UVB exposure has the most damaging effects and acts as a tumor initiator by producing irreversible mutagenic damage to the epidermis through photoproducts, photohydrates, and oxidative damage (6,7).…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis of RNA-sequencing and microarray for the identification of adverse effects of UVB exposure on human skin

Jang,

Na,

Shin

et al. 2024

Front. Public Health

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BackgroundUltraviolet B (UVB) from sunlight represents a major environmental factor that causes toxic effects resulting in structural and functional cutaneous abnormalities in most living organisms. Although numerous studies have indicated the biological mechanisms linking UVB exposure and cutaneous manifestations, they have typically originated from a single study performed under limited conditions.MethodsWe accessed all publicly accessible expression data of various skin cell types exposed to UVB, including skin biopsies, keratinocytes, and fibroblasts. We performed biological network analysis to identify the molecular mechanisms and identify genetic biomarkers.ResultsWe interpreted the inflammatory response and carcinogenesis as major UVB-induced signaling alternations and identified three candidate biomarkers (IL1B, CCL2, and LIF). Moreover, we confirmed that these three biomarkers contribute to the survival probability of patients with cutaneous melanoma, the most aggressive and lethal form of skin cancer.ConclusionOur findings will aid the understanding of UVB-induced cutaneous toxicity and the accompanying molecular mechanisms. In addition, the three candidate biomarkers that change molecular signals due to UVB exposure of skin might be related to the survival rate of patients with cutaneous melanoma.

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Inhibition of Fibroblast Growth Factor Receptor Attenuates UVB-Induced Skin Carcinogenesis

Cited by 5 publications

References 51 publications

Trends and challenges in phytotherapy and phytocosmetics for skin aging

Trends and challenges in phytotherapy and phytocosmetics for skin aging

Twist1 as a target for prevention of cutaneous squamous cell carcinoma

Integrative analysis of RNA-sequencing and microarray for the identification of adverse effects of UVB exposure on human skin

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