Trends and challenges in phytotherapy and phytocosmetics for skin aging

Ahmed, Idris Adewale; Mikail, Maryam Abimbola; Zamakshshari, Nor Hisam; Mustafa, Mohd Rais; Hashim, Najihah Mohd; Othman, Rozana

doi:10.1016/j.sjbs.2022.103363

Cited by 16 publications

(14 citation statements)

References 146 publications

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“…The low activity of P. pulmonarius extracts obtained in this study may be due to the decrease in the polysaccharides concentration, which, in turn, may be a result of the internal β‐glucanase activity. At the same time, the presence of fatty acids, proteins, phenolic compounds, steroids, and terpenoids may be responsible for the high antiproliferative and antioxidant activities of the various mushroom extracts [31,38–47] . The higher antioxidant activities of the aqueous extracts also suggest the existence of remarkable polar and active constituents in the mushroom extracts as established by the LC/MS data and in agreement with the literature [29,30] .…”

Section: Resultssupporting

confidence: 76%

Comparative Study on Biological Activities and Chemical Profiling of Mushroom (Pleurotus pulmonarius (Fr.) Quel.) Cultured on Lignocellulosic Agro Wastes

Zamakshshari

Ahmed

Nasharuddin

et al. 2023

Chemistry & Biodiversity

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The relevance of the lignocellulosic substrate in the cultivation of mushrooms has lent support to the exploration of several lignocellulosic agro wastes. This study was, thus, aimed at the evaluation of durian peel as an alternative substrate for more sustainable mushroom cultivation and climate change mitigation. The secondary metabolites and biological activities of both aqueous and organic mushroom (Pleurotus pulmonarius (Fr.) Quel.) extract cultured on durian peel and rubberwood sawdust substrate were compared using GCMS, LCMS as well as various biological assays (cytotoxicity, antimicrobial and antioxidant activities). Mushroom extracts from durian peel substrates possess remarkable biological activities. The results showed that the aqueous extracts had poor antimicrobial activities. The organic extracts were more active against cancer cells than the aqueous extracts, while the aqueous extracts were more potent as antioxidants than the organic extracts. Overall, the mushroom extract from the durian substrate was the most effective except against A549 and SW948, while the aqueous extract from the durian substrate was the most effective against the A549 cancer cell lines with 29.53±2.39 % inhibition. On the other hand, the organic mushroom extract from the sawdust substrate was the most effective against SW948 with 60.24±2.45 % inhibition. Further studies, however, are needed to elucidate the molecular mechanism of action of P. pulmonarius extracts against cancer cell proliferation and the effect of the substrates on the nutritional composition, secondary metabolites, and other biological activities of P. pulmonarius extracts.

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Section: Resultssupporting

confidence: 76%

Comparative Study on Biological Activities and Chemical Profiling of Mushroom (Pleurotus pulmonarius (Fr.) Quel.) Cultured on Lignocellulosic Agro Wastes

Zamakshshari

Ahmed

Nasharuddin

et al. 2023

Chemistry & Biodiversity

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“…Potential antiaging products or wound healing materials should inhibit the enzymes: elastase, collagenase and hyaluronidase which lead to degradation of elastin, collagen and hyaluronic acid, respectively. [55] Anti-enzymatic (anti-elastase, anti-hyaluronidase, and anti-collagenase) activities were performed on A. sintenisii. The enzyme inhibition IC 50 values of A. sintenisii for anti-elastase activity were found to be 2.32 mg/ml, 1.33 mg/ml for antihyaluronidase activity and 0.37 mg/ml for anti-collagenase activity.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

Eruygur,

Buyukyildirim,

Tetik Rama

et al. 2023

Chemistry & Biodiversity

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Achillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 μg/mg extract) and chlorogenic acid (14.97 μg/mg extract) were identified as main constituents of the extract.

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“…The goal is to be produced on a large scale at low cost, with low hazardous waste generation and highly functional remedial activity [ 6 , 7 , 8 ]. In the last decade, in the treatment of skin diseases, the demand for products with plant-based or organic polysaccharide ingredients has increased [ 9 , 10 ]. Choosing the perfect wound dressing is a crucial step that ensures the speed of regeneration of the skin wound as well as the avoidance of microbial contamination [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications

Chelu

Musuc

Aricov

et al. 2023

IJMS

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The present research aims to describe a new methodology to obtain biocompatible hydrogels based on Aloe vera used for wound healing applications. The properties of two hydrogels (differing in Aloe vera concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable and bioavailable materials such as salicylic acid, allantoin and xanthan gum were investigated. The morphology of the Aloe vera based hydrogel biomaterials was studied by SEM analysis. The rheological properties of the hydrogels, as well as their cell viability, biocompatibility and cytotoxicity, were determined. The antibacterial activity of Aloe vera based hydrogels was evaluated both on Gram-positive, Staphylococcus aureus and on Gram-negative, Pseudomonas aeruginosa strains. The obtained novel green Aloe vera based hydrogels showed good antibacterial properties. In vitro scratch assay demonstrated the capacity of both AV5 and AV10 hydrogels to accelerate cell proliferation and migration and induce closure of a wounded area. A corroboration of all morphological, rheological, cytocompatibility and cell viability results indicates that this Aloe vera based hydrogel may be suitable for wound healing applications.

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Trends and challenges in phytotherapy and phytocosmetics for skin aging

Cited by 16 publications

References 146 publications

Comparative Study on Biological Activities and Chemical Profiling of Mushroom (Pleurotus pulmonarius (Fr.) Quel.) Cultured on Lignocellulosic Agro Wastes

Comparative Study on Biological Activities and Chemical Profiling of Mushroom (Pleurotus pulmonarius (Fr.) Quel.) Cultured on Lignocellulosic Agro Wastes

Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications

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