Inhibition of ERK1/2 by silymarin in mouse mesangial cells

Youn, Cha Kyung; Cho, Sung-Il; Lee, Min Young; Jeon, Young Jin; Lee, Seog Ki

doi:10.4196/kjpp.2017.21.1.117

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The scheme used in Case 1 is shown in Table 1. [314] and have shown anti-tumor activity in renal cell carcinoma [315][316][317][318][319][320][321][322][323][324][325][326][327][328] and in other tumors as well [329][330][331][332].…”

Section: Human Case Presentationmentioning

confidence: 99%

Targeting the pH Paradigm at the Bedside: A Practical Approach

Koltai¹

2020

IJMS

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The inversion of the pH gradient in malignant tumors, known as the pH paradigm, is increasingly becoming accepted by the scientific community as a hallmark of cancer. Accumulated evidence shows that this is not simply a metabolic consequence of a dysregulated behavior, but rather an essential process in the physiopathology of accelerated proliferation and invasion. From the over-simplification of increased lactate production as the cause of the paradigm, as initially proposed, basic science researchers have arrived at highly complex and far-reaching knowledge, that substantially modified that initial belief. These new developments show that the paradigm entails a different regulation of membrane transporters, electrolyte exchangers, cellular and membrane enzymes, water trafficking, specialized membrane structures, transcription factors, and metabolic changes that go far beyond fermentative glycolysis. This complex world of dysregulations is still shuttered behind the walls of experimental laboratories and has not yet reached bedside medicine. However, there are many known pharmaceuticals and nutraceuticals that are capable of targeting the pH paradigm. Most of these products are well known, have low toxicity, and are also inexpensive. They need to be repurposed, and this would entail shorter clinical studies and enormous cost savings if we compare them with the time and expense required for the development of a new molecule. Will targeting the pH paradigm solve the “cancer problem”? Absolutely not. However, reversing the pH inversion would strongly enhance standard treatments, rendering them more efficient, and in some cases permitting lower doses of toxic drugs. This article’s goal is to describe how to reverse the pH gradient inversion with existing drugs and nutraceuticals that can easily be used in bedside medicine, without adding toxicity to established treatments. It also aims at increasing awareness among practicing physicians that targeting the pH paradigm would be able to improve the results of standard therapies. Some clinical cases will be presented as well, showing how the pH gradient inversion can be treated at the bedside in a simple manner with repurposed drugs.

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Section: Human Case Presentationmentioning

confidence: 99%

Targeting the pH Paradigm at the Bedside: A Practical Approach

Koltai¹

2020

IJMS

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Milk Thistle (Silybum marianum)

Devi

2019

Nonvitamin and Nonmineral Nutritional Supplements

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The Chemical Constituents and Pharmacological Actions of Silybum Marianum

Han

et al. 2019

CNF

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This review presents the chemical constituents and pharmacological actions of Silybum marianum. These chemical constituents include flavonolignans, fatty acids, phenolics and other chemical constituents. Furthermore, flavonolignans constituents include silymarin isosilychristin, silychristin, silydianin, silybin A, silybin B, isosilybin A, isosilybin B, etc. Pharmacological actions include a well curative effect on non-alcoholic steatohepatitis, UV damage, varieties of cancers, diabetes. In addition, its pharmacological actions include anti-inflammatory, anti-depression and more pharmacological actions. This paper will enable Silybum marianum lay the foundation for producing high and sustainable productions in the future.

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Inhibition of ERK1/2 by silymarin in mouse mesangial cells

Cited by 4 publications

References 41 publications

Targeting the pH Paradigm at the Bedside: A Practical Approach

Targeting the pH Paradigm at the Bedside: A Practical Approach

Milk Thistle (Silybum marianum)

The Chemical Constituents and Pharmacological Actions of Silybum Marianum

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