Inhibition of DNA Double-Strand Break Repair by Niclosamide in Human Colorectal Cancer Cells

Zhirnik, A. S.; Semochkina, Yu. P.; Moskaleva, E. Yu.

doi:10.1134/s1062359019120100

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…Niclosamide was reported to enhanced the radiation sensitivity of many cancer types such as lung cancers ( 62 , 67 , 137 ), triple-negative breast cancer ( 35 ), nasopharyngeal carcinoma ( 138 ), and colorectal cancer ( 139 ). Synergism between niclosamide and radiotherapy may occur in part through the ability of niclosamide to inhibit multiple adaptive pathways upregulated during or following radiation.…”

Section: Combination Of Niclosamide With Other Therapiesmentioning

confidence: 99%

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The magic bullet: Niclosamide

Jiang

2022

Front. Oncol.

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The term ‘magic bullet’ is a scientific concept proposed by the German Nobel laureate Paul Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease without harming the body. Oncologists have been looking for a magic bullet for cancer therapy ever since. However, the current therapies for cancers—including chemotherapy, radiation therapy, hormone therapy, and targeted therapy—pose either pan-cytotoxicity or only single-target efficacy, precluding their ability to function as a magic bullet. Intriguingly, niclosamide, an FDA-approved drug for treating tapeworm infections with an excellent safety profile, displays broad anti-cancer activity in a variety of contexts. In particular, niclosamide inhibits multiple oncogenic pathways such as Wnt/β-catenin, Ras, Stat3, Notch, E2F-Myc, NF-κB, and mTOR and activates tumor suppressor signaling pathways such as p53, PP2A, and AMPK. Moreover, niclosamide potentially improves immunotherapy by modulating pathways such as PD-1/PDL-1. We recently discovered that niclosamide ethanolamine (NEN) reprograms cellular metabolism through its uncoupler function, consequently remodeling the cellular epigenetic landscape to promote differentiation. Inspired by the promising results from the pre-clinical studies, several clinical trials are ongoing to assess the therapeutic effect of niclosamide in cancer patients. This current review summarizes the functions, mechanism of action, and potential applications of niclosamide in cancer therapy as a magic bullet.

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Section: Combination Of Niclosamide With Other Therapiesmentioning

confidence: 99%

“…Niclosamide inhibits the hypoxic induction of Wnt/β-catenin and HIF1α signaling, leading to tumor radiosensitivty ( 35 , 67 ). Niclosamide downregulates the expression of Ku70/80, inhibiting DNA double-strand break repair to sensitize the cancers to radiation ( 138 , 139 ).…”

Section: Combination Of Niclosamide With Other Therapiesmentioning

confidence: 99%

The magic bullet: Niclosamide

Jiang

2022

Front. Oncol.

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Inhibition of DNA Double-Strand Break Repair by Niclosamide in Human Colorectal Cancer Cells

Cited by 1 publication

References 22 publications

The magic bullet: Niclosamide

The magic bullet: Niclosamide

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