Inhibition of Cold Agglutinins (Anti-I) by M. pneumoniae Antigens

Costea, Nicolas; Yakulis, Vincent; Heller, Paul

doi:10.3181/00379727-139-36167

Cited by 31 publications

(12 citation statements)

References 4 publications

(12 reference statements)

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“…For example, Streptococcus MG strain shares glycosyl diglyceride groups with M. pneumoniae, and similarities can be found also between M. pneumoniae and the cellular components of some host tissues. [8][9][10] This raises the possibility of false positive reactions in tests using glycolipid containing antigen. The false positive reactions may be due to some heterogenic CF antibodies against some other microorganism or cellular components in tissues made free by tissue damage.411-14 Significant rises of CF serum antibodies have been reported in acute pancreatitis.14 15 Large amounts of antibodies against M. pneumoniae lipid containing antigen have also been detected in children's sera by radioimmunoprecipitation.…”

mentioning

confidence: 99%

Serological diagnosis of Mycoplasma pneumoniae infection by enzyme immunoassay.

Räisänen¹,

Suni²,

Leinikki³

1980

J Clin Pathol

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SUMMARY Antibodies against Mycoplasma pneumoniae antigen obtained by Tween-ether treatment from purified M. pneumoniae were measured by means of enzyme-linked immunosorbent assay (ELISA). Paired sera from 19 patients with pneumonia and from 13 patients with acute pancreatitis with a significant rise in complement fixing antibodies against M. pneumoniae were studied. Single sera from healthy 1-year-old children were used as controls. High levels of IgG and IgM class antibodies were seen in sera from patients with pneumonia while most patients with acute pancreatitis and all the children showed low levels of antibodies. The results indicate that ELISA using Tween-ether treated M. pneumoniae antigen could be used successfully in the specific laboratory diagnosis of M. pneumoniae infection.

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confidence: 99%

Serological diagnosis of Mycoplasma pneumoniae infection by enzyme immunoassay.

Räisänen¹,

Suni²,

Leinikki³

1980

J Clin Pathol

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“…The majority of patients with antibodies do not show symptoms (Rosenfield et al 1965, Foerster 1993. Immunologic cross-reactivity can be accepted as a cause of erythrocyte antibodies after the observation of reactivity of anti-I red blood cell antibodies with Mycoplasma antigens (Costea et al 1972). Acute bacterial infections can cause hemolytic anemia in a different way.…”

Section: Discussionmentioning

confidence: 99%

An Infant with Acute Brucellosis Presenting With Coombs-Positive Autoimmune Hemolytic Anemia: Is Breastfeeding Guilty for Transmission?

Apa

Keskin

Gülfidan

et al. 2013

Vector-Borne and Zoonotic Diseases

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Brucellosis is a zoonotic infectious disease that can be transmitted to humans through infected milk and dairy products. There are limited cases with Brucella infection acquired via breastfeeding in infants in the literature. Also, Coombs-positive autoimmune hemolytic anemia as a result of the disease is comparatively rare when considering the other frequent hematologic complications. We report a mother who acquired the infection as a result of consuming infected milk and dairy products after delivery and of her 5-month-old baby, who had acquired the disease via breastfeeding and presented with Coombs-positive autoimmune hemolytic anemia.

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“…Cold agglutinins are believed to be a result of immu nization with antigens cross-reacting with red cells and found on certain microorganisms such as M. pneumoniae [10].…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis of Anemia Associated with <i>Mycoplasma Pneumoniae</i>

Fiala¹,

Myhre²,

Chinh³

et al. 1974

Acta Haematol

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A 46-year-old female infected with Mycoplasma pneumoniae developed severe pneumonia with hypoxia and anemia; both conditions responded promptly to erythromycin. The patient’s serum contained cold agglutinins at a high titer for 18 days; the agglutinins were polyclonal, cold agglutinin idiotypenegative, and predominantly blood group I-specific. During the acute phase of illness, the patient was anergic to tuberculin. It is suggested that, in addition to hemolysis, bone marrow suppression played an important role in the pathogenesis of the anemia in our patient.

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Inhibition of Cold Agglutinins (Anti-I) by M. pneumoniae Antigens

Cited by 31 publications

References 4 publications

Serological diagnosis of Mycoplasma pneumoniae infection by enzyme immunoassay.

Serological diagnosis of Mycoplasma pneumoniae infection by enzyme immunoassay.

An Infant with Acute Brucellosis Presenting With Coombs-Positive Autoimmune Hemolytic Anemia: Is Breastfeeding Guilty for Transmission?

Pathogenesis of Anemia Associated with <i>Mycoplasma Pneumoniae</i>

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