Inhibition of choroidal neovascularization by systemic delivery of gold nanoparticles

Singh, Rupesh; Batoki, Julia C; M, Ali; Bonilha, Vera L.; Anand‐Apte, Bela

doi:10.1016/j.nano.2020.102205

Cited by 19 publications

(22 citation statements)

References 25 publications

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“…Gold nanoparticles have proven to have anti-angiogenesis and anti-inflammatory properties and can be used to treat retinal diseases [ 8 ]. In the previous laser-induced choroidal neovascularization (CNV) animal model, intravenous injection of gold nanoparticles showed significant anti-angiogenic properties [ 11 ]. AuNPs are an effective inhibitor of VEGF-induced RF/6A cell migration through the Akt/eNOS pathway [ 12 ].…”

Section: Retinopathymentioning

confidence: 99%

“…AuNPs inhibited the phosphorylation of ERK1/2, Akt, and FAK in HUVECs [ 13 ]. Optical coherence tomography (OCT)-assisted CNV volume measurement at all time points showed a significant reduction in lesion size in the group that received an intravenous injection of gold nanoparticles when compared with controls [ 11 , 14 ]. Most notably, metal nanoparticles with diameters of 20 and 80 nm (0.0065 µg/mL 20 nm AuNPs, 0.4 µg/mL 80 nm AuNPs, 0.0035 µg/mL 20 nm AgNPs, and 0.22 µg/mL 80 nm AgNPs) are toxic to photoreceptor cells in vitro [ 15 ].…”

Section: Retinopathymentioning

confidence: 99%

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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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Section: Retinopathymentioning

confidence: 99%

Section: Retinopathymentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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“…The biocompatibility of NPs was a prerequisite for the future clinical application. Recently studies have shown that many metal nanoparticles and metal oxides nanomaterials possess anti-angiogenesis activities [ 31 , 34 , 35 ]. Nevertheless, it is reported that metal nanoparticles and metal oxides nanomaterials have potential toxicity in cells or biology by causing oxidative stress, inflammation, genetic damage [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

et al. 2022

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Background Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and ocular vein occlusion, is one of the major reasons for vision loss, yet the therapeutic option is limited. Multiple nanoparticles have been reported to alleviate angiogenic retinopathy. However, the adverse effect cannot be ignored due to the relatively large scale. Graphene quantum dots (GQDs) have shown potential in drug delivery and have been proved biocompatible. In this study, Graphene quantum dots are extensively investigated for their application in angiogenic retinopathy therapy. Results We showed that GQDs were biocompatible nanomaterials in vitro and in vivo. The nanoparticles have a dose-dependent inhibitory effect on proliferation, migration, tube formation and sprouting of human umbilical vein endothelial cells (HUVECs). Further data show that GQDs could inhibit pathological retinal neovascularization in an oxygen-induced retinopathy (OIR) model. The data of RNA sequencing suggested that periostin is involved in this process. GQDs inhibit the expression of periostin via STAT3, and further regulated cell cycle-related protein levels through ERK pathway. The signaling pathway was conformed in vivo using OIR mouse model. Conclusions The present study indicated that GQDs could be a biocompatible anti-angiogenic nanomedicine in the treatment of pathological retinal neovascularization via disrupting periostin/ERK pathway and subsequent cell cycle. Graphical Abstract

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“…The biocompatibility of NPs was a prerequisite for the future clinical application. Recently studies have shown that many metal nanoparticles and metal oxides nanomaterials possess anti-angiogenesis activities [31,34,35]. Nevertheless, it is reported that metal nanoparticles and metal oxides nanomaterials have potential toxicity in cells or biology by causing oxidative stress, in ammation, genetic damage [36,37].…”

Section: Discussionmentioning

confidence: 99%

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

Zhao

Xiao

Qian

et al. 2022

Preprint

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Background: Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and ocular vein occlusion, is one of the major reasons for vision loss, yet the therapeutic option is limited. Multiple nanoparticles have been reported to alleviate angiogenic retinopathy. However, the adverse effect cannot be ignored due to the relatively large scale. Graphene quantum dots (GQDs) have shown potential in drug delivery and have been proved biocompatible. In this study, Graphene quantum dots are extensively investigated for their application in angiogenic retinopathy therapy. Results: We showed that GQDs were biocompatible nanomaterials in vitro and in vivo. The nanoparticles have a dose-dependent inhibitory effect on proliferation, migration, tube formation and sprouting of human umbilical vein endothelial cells (HUVECs). Further data show that GQDs could inhibit pathological retinal neovascularization in an oxygen-induced retinopathy (OIR) model. The data of RNA sequencing suggested that periostin is involved in this process. GQDs inhibit the expression of periostin via STAT3, and further regulated cell cycle-related protein levels through ERK pathway. The signaling pathway was conformed in vivo using OIR mouse model. Conclusions: The present study indicated that GQDs could be a biocompatible anti-angiogenic nanomedicine in the treatment of pathological retinal neovascularization via disrupting periostin/ERK pathway and subsequent cell cycle.

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Inhibition of choroidal neovascularization by systemic delivery of gold nanoparticles

Cited by 19 publications

References 25 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

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