Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

Zhao, Na; Xiao, Gui; Fang, Qian; Zhang, Rui; Zhu, Weiye; Zhang, Haorui; Li, Qing; Zhou, Yukun; Zhao, Jiawei; Cui, Xiao; Gao, Guangping; Tang, Huipeng; Shen, Ni; Chen, Taoyong; Song, Hongyuan; Shen, Wei

doi:10.1186/s12951-022-01362-4

Cited by 24 publications

(19 citation statements)

References 49 publications

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“…Zhao et al., reported the development of graphene quantum dots (also referred to as CDs) as biocompatible anti‐angiogenic nanomedicines that are effective in treating pathological retinal neovascularization by disrupting the STAT3/periostin/ERK pathway and subsequent downstream of cell cycle pathways by biocompatible CDs nanomaterials ( Figure a). [ 73 ] The number of capillary‐like structures decreased in the CDs treated groups in comparison to the control groups, as shown in Figure 5b,c. To further verify the anti‐angiogenic properties of CDs in vitro, Zhao et al.…”

Section: Ophthalmic Applications Of Cd‐based Nanomaterialsmentioning

confidence: 90%

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Functional Carbon Quantum Dots for Ocular Imaging and Therapeutic Applications

Kumar

Sher

Rencus‐Lazar

et al. 2022

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functional groups such as CHO, CO, NH 2 , OH, COOH, COC, CN, NO, SH, or polymer aggregates. [11] Moreover, CDs are considered to be the most recent form of zero-dimensional carbon, with a diameter of less than 10 nm and excellent fluorescent properties. [12] These properties have led to their application in biomedical engineering [13] and sensor technology, [14,15] including heavy metal ion detection, [16] fluorescent labeling and nucleus targeted imaging of cells, [17] targeting of drug delivery for anti-tumor therapy, [18] photovoltaic devices/solar cell, [19] photocatalysts, [20] dye degradation, [21] lubricant additive, [22] supercapacitor, [23] nanoelectronic devices, [24] fuel cells, [25] anti-viral therapy, [26] photodynamic therapy, [27] gene delivery, [28] and disruption of the fibrillation of amyloidogenic peptides, such as Aβ. [29,30] Recently, Shah et al. have investigated the presence of Aβ in aging eyes and its significance in relation to Alzheimer's disease (AD) pathology. [31] They have also discussed clinical studies investigating the in vivo ocular imaging of Aβ and its relationship to brain Aβ burden, as well as therapies that target ocular Aβ. [31] Therefore, the characterization of retinal Aβ is also necessary in order to differentiate it from eye-related diseases.According to the World Health Organization, more than 2.2 billion individuals were affected by some form of visual impairment in 2020, with an estimated 35 million blind individuals. [32][33][34] Among the leading causes of vision loss Carbon quantum dots (CDs) are a class of emerging carbonaceous nanomaterials that have received considerable attention due to their excellent fluorescent properties, extremely small size, ability to penetrate cells and tissues, ease of synthesis, surface modification, low cytotoxicity, and superior water dispersion. In light of these properties, CDs are extensively investigated as candidates for bioimaging probes, efficient drug carriers, and disease diagnostics. Functionalized CDs represent a promising therapeutic candidate for ocular diseases. Here, this work reviews the potential use of functionalized CDs in the diagnosis and treatment of eye-related diseases, including the treatment of macular and anterior segment diseases, as well as targeting Aβ amyloids in the retina.

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Section: Ophthalmic Applications Of Cd‐based Nanomaterialsmentioning

confidence: 90%

“…e,f) HUVEC sprouting was quantified by measuring the sprouting length of the HUVECs and the number of sprouts surrounding the sphere. Reproduced with permission [73]. Copyright 2022, Springer Nature.…”

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confidence: 99%

Functional Carbon Quantum Dots for Ocular Imaging and Therapeutic Applications

Kumar

Sher

Rencus‐Lazar

et al. 2022

Small

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“…Zhao et al (Zhao, Gui et al, 2022) found that graphene quantum dots (average particle size of 3.6 nm) inhibited the proliferation and cell migration of human umbilical vein endothelial cells in vitro. In the oxygen-induced retinopathy (OIR) model, graphene quantum dots were effective in ameliorating pathological angiogenesis.…”

Section: Anti-angiogenesis (Angiogenesisrelated Eye Diseases)mentioning

confidence: 99%

Nanoparticles in ocular applications and their potential toxicity

Cao

Yang

et al. 2022

Front. Mol. Biosci.

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Nanotechnology has been developed rapidly in recent decades and widely applied in ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current ophthalmic drug delivery and are characterized with strong biocompatibility, stability, efficiency, sustainability, controllability, and few side effects. Nanoparticles have been identified as a promising and generally safe ophthalmic drug-delivery system based on the toxicity assessment in animals. Previous studies have found that common nanoparticles can be toxic to the cornea, conjunctiva, and retina under certain conditions. Because of the species differences between humans and animals, advanced in vitro cell culture techniques, such as human organoids, can mimic the human organism to a certain extent, bringing nanoparticle toxicity assessment to a new stage. This review summarizes the advanced application of nanoparticles in ocular drug delivery and the potential toxicity, as well as some of the current challenges and future opportunities in nanotoxicological evaluation.

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“…14). 268 Pramanik et al reported that GQDs linked to human antimicrobial peptide (LL-37) and human neutrophil polypeptide (HNP1) inhibit viral infection by blocking the binding of the SARS-COV-2 variant (B.1.617.2) of the spike protein receptor binding domain (RBD) to angiotensin converting enzyme 2 (ACE2) in human cells. Compared with GQDs that are combined with a single peptide, the inhibition efficiency of the LL-37 and HNP1 dual-polypeptide combination was greatly improved.…”

Section: Biological Applications Of Quantum Dotsmentioning

confidence: 99%