Inhibition of cholinesterase activity by extracts, fractions and compounds from Calceolaria talcana and C. integrifolia (Calceolariaceae: Scrophulariaceae)

Cespedes‐Acuña, Carlos L.; Muñoz, Érika Caballero; Salazar, Juan Rodrigo; Yamaguchi, Lydia F.; Werner, Enrique; Alarcón, Julio; Kubo, Isao

doi:10.1016/j.fct.2013.10.027

Cited by 30 publications

(35 citation statements)

References 46 publications

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“…Therefore, the inhibition of acetylcholinesterase (AChE) activity, leads to the persistence of active acetylcholine in synaptic clefts, leading to interfere with nerve transmission, which could be one of the possible reason of fumigant toxicity of test EO. Similar supportive observation has been reported for the most of commercially available synthetic insecticide such as organophosphate and carbamates (Costa, 2006;Cespedes et al, 2013). In addition, it has been reported that oxidative stress is one of the possible mechanism of the non-target toxicity of commercially available organophosphates to the mammalian system (Gupta et al, 1998;Bebe and Panemangalore, 2005).…”

Section: Discussionsupporting

confidence: 54%

“…Currently, organophosphates, carbamates, pyrethroids, and phosphine are widely used to protect stored-food commodities against insect pest infestation (Cespedes et al, 2013;Ebadollahi, 2013). These insecticides are primarily recognized for their ability to induce toxicity in organisms through inhibition of acetylcholinesterase (AChE), activation of cholinergic receptors and oxidative imbalance (Costa, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Toxicity and biochemical efficacy of chemically characterized Rosmarinus officinalis essential oil against Sitophilus oryzae and Oryzaephilus surinamensis

Kıran

Prakash

2015

Industrial Crops and Products

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Toxicity and biochemical efficacy of chemically characterized Rosmarinus officinalis essential oil against Sitophilus oryzae and Oryzaephilus surinamensis

Kıran

Prakash

2015

Industrial Crops and Products

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“…The mode of action of the carbamate insecticides is similar to that of the organophosphates on the CNS, and the symptoms of intoxication are similar to those with the organophosphates. Decarbamylation of acetylcholinesterase is rapid, typically in minutes, and, therefore, the carbamate insecticides are regarded as reversible acetylcholinesterase inhibitors (Matsumura 1985 ;Von Osten et al 2004 ;Casida and Durkin 2013 ;Cespedes et al 2013 ).…”

Section: Inhibition Of Acetylcholinesterasementioning

confidence: 99%

Mode of Action of Plant-Derived Natural Insecticides

Shivanandappa

Rajashekar

2014

Advances in Plant Biopesticides

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Most of the chemical insecticides are neurotoxic, acting on targets in the central nervous system such as the membrane ion channels (DDT, pyrethroids), the enzyme acetylcholinesterase (organophosphate, carbamate), and the receptors of neurotransmitters (avermectins, neonicotinoids). The recently introduced diamide group of insecticides target the novel ryanodine receptor in the nervous system. Since pests continue to evolve resistance to compounds currently in use, new compounds with new modes of action are needed. Natural products could be a promising source for novel pest control agents. The origin of many of the important insecticide classes is traceable to a natural source as in the case of pyrethroids, avermectins, spinosads, and neonicotinoids. Although insect control agents acting on targets other than the nervous system such as insect growth regulators (e.g., azadirachtin, JH analogues, ecdysone antagonists) have been developed, due to their lack of contact toxicity, they are not quite successful, but fi nd a place in the integrated pest management. Recent progress in understanding the biology of insect olfaction and taste offers new strategies for developing selective pest control agents. Decalesides, recently discovered natural insecticides, represent a new class of plant-derived insecticides targeting the tarsal gustatory receptors. In this chapter, we focus on the toxicity and mode of action of natural insecticides.

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“…The presence of a furan ring may be responsible for the greater level of activity of tanshonine activity against AChE than observed in taxodione. However, diterpenoids such as 1,10-cyclopropyl-9-epi-ent-isopimarol and 1,19-α-hydroxy-abietatriene do not demonstrate anti-AChE activity (Cespedes et al, 2013). These compounds have no phenolic groups and Cespedes et al (2013) suggested that such groups determine the ability to inhibit cholinesterase.…”

Section: Biochemical Studiesmentioning

confidence: 99%

“…However, diterpenoids such as 1,10-cyclopropyl-9-epi-ent-isopimarol and 1,19-α-hydroxy-abietatriene do not demonstrate anti-AChE activity (Cespedes et al, 2013). These compounds have no phenolic groups and Cespedes et al (2013) suggested that such groups determine the ability to inhibit cholinesterase. In the structure of taxodione, a phenolic group is present at C-11 ( Fig.…”

Section: Biochemical Studiesmentioning

confidence: 99%

Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors

Kuźma

Wysokińska

Sikora³

et al. 2015

Phytother. Res.

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Taxodione, an abietane diterpenoid, was isolated from Salvia austriaca transformed roots grown in in vitro conditions. The compound is known to have antibacterial, cytotoxic and anti-tumour properties. This study evaluates the ability of pure taxodione and extracts obtained from the S. austriaca hairy roots and roots from field-grown plants to inhibit human acetylcholinesterase and butyrylcholinesterase. Both extracts were found to have similar actions against acetylcholinesterase. The IC50 for extracts from transformed and untransformed roots were 142.5 and 139.5 µg ml(-1), respectively. The highest activity towards human acetylcholinesterase was demonstrated by taxodione (IC50 = 54.84 µg ml(-1)). With respect to BChE inhibition, the root extracts demonstrated stronger activity (IC50 = 23.6 µg ml(-1): field-grown plants and 41.6 µg ml(-1): transformed roots) than taxodione (IC50 = 195.9 µg ml(-1)). Taxodione showed significant cytotoxicity against A549 cell line (IC50 = 9.1 µg ml(-1)), whereas the activities for the extracts from S. austriaca roots of field-grown plants (IC50 = 75.7 µg ml(-1)) and hairy roots (IC50 = 86.2 µg ml(-1)) were lower. Computer modelling suggests that taxodione should not demonstrate cardiotoxic or genotoxic activity. It also indicates that taxodione should demonstrate very rapid transport from the body with very good blood-brain barrier penetration, but with no cumulative effect on the human body. The obtained results indicate that taxodione is a safe compound and may be used for further investigations in pharmacological activities.

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Inhibition of cholinesterase activity by extracts, fractions and compounds from Calceolaria talcana and C. integrifolia (Calceolariaceae: Scrophulariaceae)

Cited by 30 publications

References 46 publications

Toxicity and biochemical efficacy of chemically characterized Rosmarinus officinalis essential oil against Sitophilus oryzae and Oryzaephilus surinamensis

Toxicity and biochemical efficacy of chemically characterized Rosmarinus officinalis essential oil against Sitophilus oryzae and Oryzaephilus surinamensis

Mode of Action of Plant-Derived Natural Insecticides

Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors

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