Inhibition of Cholesterol Biosynthesis by Bovine Milk, Cultured Buttermilk, and Orotic Acid

Bernstein, B. A.; Richardson, Thomas; Amundson, C. H.

doi:10.3168/jds.s0022-0302(76)84237-3

Cited by 22 publications

(1 citation statement)

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“…A relative hypocholesterolemic effect of SMP to that observed with casein was, however, observed in rats fed diets containing cholesterol. It has been stated that the calcium (Howard, 1977), lactose (Marks and Howard, 1977), erotic acid (Bernstein et al, 1975) and inhibitors of cholesterol biosynthesis are implicated in the reduced cholesterolemic effect of milk. More recently, Sautier et al (1983) reported that whey protein when compared to casein has the ability to decrease TSC in rats, to concentrations comparable to soybean and sunflower proteins.…”

Section: Discussionmentioning

confidence: 99%

Temporal Changes in Serum Cholesterol Levels of Rats Fed Casein and Skim Milk Powdered Diets

Kanhai

KIlTS

Powrie

1987

Journal of Food Science

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The temporal cholesterolemic patterns to skim milk powder (SMP) and reprocessed SMP (RSMP) diets were compared to diets containing casein or laboratory rat chow over a 24-day period. SMP was hypocholestetemic relative to casein in rats fed a 1% dietary cholesterol. Reprocessing of SMP resulted in an apparent loss of the relative hypocholesterolemic reponse of native SMP. Amino acid analysis of SMP and RSMP, showed only marginally lower lysine levels than casein; however, the IysineIarginine ratio was higher in SMP than either in casein or RSMP. Available lysine content in SMP was higher than in RSMP, suggesting occurrence of nonenyzmatic browning reactions. Although a similar cholesterolemic response was observed in casein and RSMP, the available lysine content of these two protein sources were markedly different, suggesting that reduced available lysine alone was not totally responsible for the lower cholesterolemic response of SMP, relative to casein.

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Section: Discussionmentioning

confidence: 99%