Inhibition of Cholesterol Biosynthesis and Acetyl-Coenzyme A Synthetase by Bovine Milk and Orotic Acid

Bernstein, B. A.; Richardson, Thomas; Amundson, C. H.

doi:10.3168/jds.s0022-0302(77)84112-x

Cited by 29 publications

(9 citation statements)

References 26 publications

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“…Recent evidence suggests that I three organic acids are likely hypocholesterolemic agents. Hydroxymethylglutaric (HMG) and erotic acids lower serum cholesterol when fed to rats (Beg and Siddiqi, 1968;Bernstein et al, 1977) and humans (Robinson and Dombrowski, 1983), while uric acid has been identified as a cholesterol synthesis inhibitor from human milk (Ward et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

Jaspers

Massey

Luedecke

1984

Journal of Food Science

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Ten human adult males' usual diets were modified by incorporating 681g nonfat, unpasteurized yogurt daily throughout three 1421 day periods. A different set of select culture strains, two commercial and one patented, were used for yogurt production in the three dietary periods. Including yogurt daily in the diet significantly reduced fasting total serum cholesterol l&12% in human adult males on some days, but serum cholesterol returned towards control values with continued yogurt consumption. Serum triglycerides and the proportions of serum lipoproteins were not significantly influenced by increasing yogurt consumption. Differences in concentrations of uric, erotic and hydroxymethylglutaric-like acids in the yogurts were insufficient to account for the differences in temporary hypocholesterolemic effects of yogurt consumption seen between strains.

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Section: Introductionmentioning

confidence: 99%

Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

Jaspers

Massey

Luedecke

1984

Journal of Food Science

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“…Other simpler compounds, such allicine from garlic, inhibit acetyl CoA synthetase [34]. This is also the case of an active substance from cow milk, which could be orotic acid [35]. Orotic acid and allicin are available as tablets.…”

Section: Scot Inhibition: a Possible Cancer Treatmentmentioning

confidence: 99%

The metabolic rewiring observed in cancer renders tumor cells dependent of ketone bodies and vulnerable to SCOT inhibition

2020

Endocrinol Diabetes Metab J

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The finding that autoantibodies against glutamic acid decarboxylase that synthesizes GABA, provoke Diabetes type I, draws attention on a GABAergic regulation of the endocrine pancreas suppressing catabolic glucagon release if anabolic insulin is liberated; a GABA deficiency would then impair this exclusion mechanism, allowing a release of both hormones. Moreover, the GABA deficiency alters a mechanism terminating insulin release; an insulin leakage renders differentiated cells gradually resistant to insulin, while responding to glucagon. Mitotic cells with new insulin receptors, respond to both hormones, displaying a hybrid metabolic pattern typically found in tumor cells. They cannot get their mitochondrial acetyl CoA from glycolysis, since pyruvate kinase and pyruvate dehydrogenase are OFF, following the glucagon signal. Nor can they form acetyl CoA by the beta-oxidation of fatty acids, since the insulin signal they receive elicits the synthesis of fatty acids, which automatically closes their beta-oxidation. Indeed, malonyl CoA produced along the lipogenic pathway inhibits the mitochondrial carnityl-transporter of fatty acids. Hence, with both the glycolytic and fatty acid sources of mitochondrial acetyl CoA closed, tumor cells can only get their vital mitochondrial acetyl CoA supply from the ketolysis of ketone bodies.

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Section: -Peso Do Fígado Dos Animais Experimentaisunclassified

“…Embora essa diferença não seja significativa, é indicativo da tendên-cia de que leites fermentados podem provocar o desvio do colesterol sérico para o fígado, promovendo sua deposição neste órgão [4]. BERNSTEIN et al [4] se referiram à diminuição do colesterol sérico pelo leite fermentado, no entanto, a essa redução, seguiu-se a indução de fígado gorduroso. Kinsella, 1967 citado por BERNSTEIN et al [4] demonstrou que ratos alimentados com leite fermentado desenvolviam fígado gorduroso após decréscimo do colesterol plasmático, corroborando o desvio das concentrações séricas deste esterol para o fígado.…”

Section: -Peso Do Fígado Dos Animais Experimentaisunclassified

“…BERNSTEIN et al [4] se referiram à diminuição do colesterol sérico pelo leite fermentado, no entanto, a essa redução, seguiu-se a indução de fígado gorduroso. Kinsella, 1967 citado por BERNSTEIN et al [4] demonstrou que ratos alimentados com leite fermentado desenvolviam fígado gorduroso após decréscimo do colesterol plasmático, corroborando o desvio das concentrações séricas deste esterol para o fígado.…”

Section: -Peso Do Fígado Dos Animais Experimentaisunclassified

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Efeito de probiótico na modulação dos níveis de colesterol sérico e no peso do fígado de ratos alimentados com dieta rica em colesterol e ácido cólico

Machado¹,

Ferreira²,

Costa

et al. 2003

Ciênc. Tecnol. Aliment.

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Efeito de probiótico na modulação dos níveis de colesterol sérico e no peso do fígado de ratos, Machado et al. -INTRODUÇÂONo Brasil, as doenças cardiovasculares são responsáveis por cerca de 300 mil falecimentos por ano, ou seja, 820 por dia. Nos Estados Unidos, são responsáveis por 70 a 80% das mortes de pessoas com mais de 65 anos e de acordo com estimativa, no ano 2003, um em cada cinco indivíduos terá mais de 65 anos [23].A Organização Mundial de Saúde OMS [19] ressalta que o aumento da expectativa de vida de uma população está diretamente relacionada com a prevenção das doenças cardiovasculares.O risco destas doenças, que incluem o infarto e a aterosclerose, tem sido continuamente associado a ní-veis elevados de colesterol sangüíneo e pequena redução do seu nível plasmático está relacionada a um decréscimo significativo desse risco [2].Sabe-se que o principal papel da dieta é fornecer nutrientes para satisfazer os requerimentos de uma alimentação balanceada e ao mesmo tempo proporcionar um sentimento de satisfação e bem-estar ao comensal. SUMMARY EVALUATION OF THE PROBIOTIC EFFECT IN THE MODULATION OF THE LEVELS OF SERIC CHOLESTEROL AND IN THE WEIGHT OF THE LIVER OF MICES FED WITH RICH DIET IN CHOLESTEROL AND COLIC ACID.Probiotics are known as functional foods and have been recommended as dietary adjunct for individuals with high serum cholesterol levels. To evaluate probiotics effects on the modulation of serum cholesterol an experiment was carried out during 28 days, using 90 Wistar male rats, distributed in four treatments and individually housed, with initial average weight of 250±32g. The experimental groups were: Standard; Control; LDR and P. The Standard group received the AIN-93G diet during the whole experimental period. The other groups received for 28 days the AIN-93G diet added of 1% of cholesterol and 0,1% of cholic acid. Of the 15 th to the 28 th day (after an initial period of 14 days of hipercolesterolemia induction) the LDR group received the supplement of 0,1mL/day/animal of reconstituted skimmed milk at 10% of non fat solids and, the group P received 0,1mL/day/animal of a probiotic in the form of a concentrate of cells contends 10 10 UFC/mL of Lactobacillus acidophilus NCFM. Total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) were evaluated at 28 th days of experiment (immediately after the end of probiotic administration). The dietary increment of 1% of crystalline cholesterol and 0,1% of cholic acid did not promote hipercholesterolemia in the animals, evidenced by the non significant difference (p>0,05) of levels of total cholesterol, LDL-cholesterol and HDL-cholesterol among the groups Standard, Control, LDR and P after 14 days receiving hipercholesterolemic diet. However it provoked significant increase of the weight and alteration of normal coloration of liver (of red intense for red yellowish) due to fat accumulation in this organ, in the animals that received rich diet in cholesterol compared to the Standard group. Thus, rich diet in cholesterol and...

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Inhibition of Cholesterol Biosynthesis and Acetyl-Coenzyme A Synthetase by Bovine Milk and Orotic Acid

Cited by 29 publications

References 26 publications

Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

The metabolic rewiring observed in cancer renders tumor cells dependent of ketone bodies and vulnerable to SCOT inhibition

Efeito de probiótico na modulação dos níveis de colesterol sérico e no peso do fígado de ratos alimentados com dieta rica em colesterol e ácido cólico

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