Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus

Bild, Walther; Hrițcu, Lucian; Ștefănescu, Cristinel; Ciobîcă, Alin

doi:10.1016/j.pnpbp.2012.12.009

Cited by 78 publications

(70 citation statements)

References 95 publications

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“…50 ACE inhibitors are well documented in the production of anti-inflammatory action by reduction of angiotensin II formation. 51,52 Angiotensin II exerted an anti-nociceptive effect at the variable time points but generally it has high pain sensitivity, because the pain attenuating effect is in a diurnal pattern (24 h light and dark cycles). At phasic pain (dark cycle), it exerted an anti-nociceptive effect, whereas in tonic pain (light cycle), it exerted weak circadian fluctuation of the number of pain responses in mice.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice

Kaur

Muthuraman

Kaur

2014

J Renin Angiotensin Aldosterone Syst

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Introduction: The present study was designed to investigate the effect of ramipril (angiotensin-converting enzyme inhibitor) on the chronic constriction injury of sciatic nerve induced neuropathic pain in mice. Methods: The neuropathic pain was induced by four loose ligations of the right sciatic nerve in mice. The battery of behavioral tests, i.e. plantar, pin prick, tail flick, tail pinch, rota rod tests, were performed to assess the degree of thermal and mechanical hyperalgesia in ipsilateral paw and tail, and motor in-coordination activity respectively. In addition, the biochemical tests, i.e. total protein, thiobarbituric acid reactive substances and reduced glutathione, were also performed in sciatic nerve tissue samples. Results: The administration of ramipril (2 and 4 mg/kg, p.o.) significantly attenuated chronic constriction injury-induced rise in peripheral as well as central pain sensitivity (thermal and mechanical) along with impairment of motor in-coordination activity. Further, it also produces ameliorative effects on chronic constriction injury-induced rise in thiobarbituric acid reactive substances and decrease in glutathione levels when compared with a normal control group. Conclusion: It may be concluded that angiotensin-converting enzyme inhibitor may be a potential new target for the management of neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

“…ACE inhibitors are responsible for the reduction of blood pressure and neuroprotective action. 52 The elevation of blood pressure has been reported to produce a reduction in pain sensitivity. The over activation of the RAAS is responsible for the rise in blood pressure, but the role in neuropathic pain has not been explored yet.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice

Kaur

Muthuraman

Kaur

2014

J Renin Angiotensin Aldosterone Syst

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“…This kit uses an indirect method, based on the oxidation of glutathione (GSH) to oxidized glutathione (GSSG) catalyzed by GPx, which is then coupled with recycling GSSG back to GSH utilizing glutathione reductase (GR) and NADPH. The decrease in NADPH absorbance at 340 nm during oxidation of NADPH to NADP is indicative of GPx activity [33].…”

Section: Glutathione Peroxidase Measurementmentioning

confidence: 99%

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

Ciobîcă¹,

Lefter²,

Stoica³

2017

Fiziol Zh

Self Cite

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“…Considering the importance of the animal models in the present research status [18][19][20], studies on canine models of chronic pancreatitis and PP deficiency also demonstrated hepatic resistance to insulin with inadequate production of glucose in the liver, despite normal levels of insulin. Moreover, PP deficient status occurs frequently after surgical resection, considering that the hormone is predominantly localized in the cephalic pancreas.…”

Section: The Pancreatic Polypeptide Pp and The Pancreatic Glucose Metmentioning

confidence: 99%

Mini-Review on the Glucose Metabolism Modifications after Pancreatic Resection

Timofte

Ionescu

Ochiuz

2016

ILNS

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Abstract. Pancreatic cancer is one of the most severe malignant disease, with an extreme degree of lethality, considering that the survival rate at 5 years is up to 4%. In addition, a major disadvantage of this disease is the fact that the diagnosis is determined very late in the evolution of the disorder, despite the development of new technologies. In this way, the main symptoms are occurring later on, when the tumour is well to advanced and totally unresectable. Up to now surgery is the only modality that can provide a greater chance of survival, but unfortunately the pancreatic resection has many unknowns and controversies around it. Moreover, the studies on endocrine pancreatic function after resection are very few and somehow controversial. In this way, in the present minireview we will describe the most relevant experimental data regarding the post-resection pancreatogenic diabetes, the pancreatic polypeptide PP and the pancreatic glucose metabolism after resection or the glucose metabolism after partial or total pancreatectomy.

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Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus

Cited by 78 publications

References 95 publications

Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice

Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

Mini-Review on the Glucose Metabolism Modifications after Pancreatic Resection

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