Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative Stress

Ciobîcă, Alin; Hrițcu, Lucian; Năstasă, V; Pădurariu, Manuela; Bild, Walther

doi:10.2478/v10011-011-0009-3

Cited by 26 publications

(23 citation statements)

References 22 publications

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“…It is approximately eight times more active as an inhibitor of ACE activity as compared to trandolaprilat. It also possesses a long elimination half-life, strong lipophilicity, high ACE inhibitor potency, high affinity for the ACE and a long biological half-life (Ciobica et al, 2011).…”

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confidence: 99%

Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: Mitochondrial dysfunction and neurodegeneration

et al. 2014

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Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: Mitochondrial dysfunction and neurodegeneration

et al. 2014

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“…Oxidative stress is the condition arising from the imbalance between toxic reactive oxygen species (ROS) and antioxidant systems (5), being also recognized as a very important mechanism in a variety of pathologies (6) including neuropsychiatric disorders, as our group has previously demonstrated (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Alexinschi¹,

Chiriță²,

Ciobîcă³

et al. 2014

Journal of Medical Biochemistry

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SummaryBackground: Although it is generally accepted that there is an increased oxidative stress status in alcoholics, the separate relevance of oxidative stress following alcohol withdrawal is still not understood to this date. There are reports stating that the increased oxidative stress status in alcoholics may persist independently of the constant presence of alcohol intake, while on the other side, it was demonstrated that the antioxidant defense mechanism could significantly increase after alcohol withdrawal. Methods: In the present work, we were interested in studying the relevance of oxidative stress status in the alcohol withdrawal processes, by determining some oxidative stress markers (two antioxidant enzymes: superoxide dismutase -SOD and glutathione peroxidase -GPX and a lipid peroxidation maker -MDA) after one week and one month of abstinence, as compared to the baseline and a control group of subjects. Results: Our data confirmed the increased oxidative stress status in alcoholic patients and, more importantly, we de monstrated here a significant decrease of the oxidative stress status one week and one month following the withdrawal, as showed by a significant increase in the specific activity of

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“…Numerous studies have led to the identification of two pharmacologically specific angiotensin receptors type 1 (AT 1) and type 2 (AT 2), which are well represented in various brain areas (10). Our group also previously demonstrated that the administration of losartan and PD-123177, which are selective antagonists for the AT 1 and AT 2, re sults in anxiolytic effects in rats (7). Also, similar effects were reported as the result of angiotensin-converting enzyme (ACE) inhibitors like captopril (7), which is also commonly used as an antihypertensive drug (11).…”

Section: Introductionmentioning

confidence: 58%

The Effects of Central Angiotensin II and Its Specific Blockers on Nociception. Possible Interactions with Oxidative Stress Status / Efekti Centralnog Angiotenzina II I Njegovih Specifičnih Blokatora Na Nocicepciju. Moguće Interakcije Sa Statusom Oksidativnog Stresa

Arcan¹,

Ciobîcă²,

Bild³

et al. 2013

Journal of Medical Biochemistry

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Summary:It has already been demonstrated that a complete brain renin-angiotensin system (RAS) exists distinctly separate from the peripheral system and is implicated in complex functions such as memory, emotional responses and pain. Regarding the implications of angiotensin II (the main bioactive peptide of RAS) in pain, although there are many studies in this area of research, most of the results are contro versial. Also, it seems that oxidative stress follows angio tensin II infusion, but the role of AT1 vs. AT2 receptors is not well established. In this context, we were interested in studying the effects of central RAS on nociception, through the in tra cerebroventricular administration of losartan and PD-123177 (antagonists for the AT1/AT2 receptors), as well as an ACE inhibitor (captopril) and also angiotensin II in rats, which were subsequently tested using the hot-plate task, a well known behavio ral test for pain perception. We present here the analgesic effect of angiotensin II administration, as shown by in crea sed latency-time in the hot-plate, as well as a nociceptive effect of angiotensin II blockers like AT1 and AT2 specific antagonists (losartan and PD-123177) and an ACE inhibitor (captopril), as their administration resulted in decreased la ten cy-time. Moreover, we demonstrated a significant correlation between the results of the nociceptive Kratak sadr`aj: Do sada je ve} pokazano da kompletan mo`dani renin-angiotenzin sistem (RAS) postoji zasebno od perifernog sistema i da je uklju~en u slo`ene funkcije kao {to su memorija, emocionalni odgovori i bol. [to se ti~e implikacija angiotenzina II (glavnog bioaktivnog peptida RAS) u bolu, mada u ovoj oblasti istra`ivanja postoje mnoge studije, rezultati su ve}inom opre~ni. Tako|e, izgleda da infuziju angiotenzina II prati oksidativni stres, ali uloga receptora AT1 i AT2 jo{ nije razja{njena. U tom kontekstu hteli smo da prou~imo efekte centralnog RAS na nocicepciju preko intracerebroventrikularne administracije lozartana i PD-123177 (antagonista za receptore AT1/AT2) kao i jednog ACE in hibitora (kaptopril) i angiotenzina II kod pacova, koji su potom testirani metodom grejne plo~e, poznatim bihevioralnim testom za percepciju bola. Predstavljamo analgeti~ki efekat administracije angiotenzina II pokazan kroz pove}anu latenciju na grejnoj plo~i, kao i nociceptivni efekat blokatora angiotenzina II kao {to su antagonisti specifi~ni za AT1 i AT2 (lozartan i PD-123177) i ACE inhibitora (kaptopril), po{to je rezultat njihove administracije bila smanjena latencija. [tavi{e, uo~ili smo zna~ajnu korelaciju izme|u rezultata nociceptivnog bihevioralnog testa i nivoa nekih od glavnih markera oksidativnog stresa. Na taj na~in obezbe|eni su novi

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Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative Stress

Cited by 26 publications

References 22 publications

Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: Mitochondrial dysfunction and neurodegeneration

Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: Mitochondrial dysfunction and neurodegeneration

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

The Effects of Central Angiotensin II and Its Specific Blockers on Nociception. Possible Interactions with Oxidative Stress Status / Efekti Centralnog Angiotenzina II I Njegovih Specifičnih Blokatora Na Nocicepciju. Moguće Interakcije Sa Statusom Oksidativnog Stresa

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