Inhibition of Candida albicans hypha formation in biofilm formation by Ruta angustifolia extract

Noer, Shafa; Abinawanto, .; Bachtiar, Endang W.; Bowolaksono, Anom

doi:10.1063/5.0041682

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…In addition, alkaloids contribute to the antifungal activity of the plant, notably arborinine and graveoline present in the leaves of R. angustifolia , as detailed below [ 19 ]. Recently, an activity has been mentioned also using an ethanolic leave extract of R. angustifolia on a preformed biofilm of C. albicans , but no quantitative information was reported [ 20 ].…”

Section: Pharmacological Activities Of R Angustifolia ...mentioning

confidence: 99%

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Bailly

2023

Plants

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The genus Ruta in the family Rutaceae includes about 40 species, such as the well-known plants R. graveolens L. (common rue) or R. chalepensis L. (fringed rue), but also much lesser-known species such as R. angustifolia Pers. (narrow-leaved fringed rue). This rue specie, originating from the Mediterranean region, is well-distributed in Southeast Asia, notably in the Indo-Chinese peninsula and other territories. In some countries, such as Malaysia, the plant is used to treat liver diseases and cancer. Extracts of R. angustifolia display antifungal, antiviral and antiparasitic effects. Diverse bioactive natural products have been isolated from the aerial parts of the plant, notably quinoline alkaloids and furocoumarins, which present noticeable anti-inflammatory, antioxidant and/or antiproliferative properties. The present review discusses the main pharmacological properties of the plant and its phytoconstituents, with a focus on the anticancer activities evidenced with diverse alkaloids and terpenoids isolated from the aerial parts of the plant. Quinoline alkaloids such as graveoline, kokusaginine, and arborinine have been characterized and their mode of action defined. Arborinine stands as a remarkable inhibitor of histone demethylase LSD1, endowed with promising anticancer activities. Other anticancer compounds, such as the furocoumarins chalepin and rutamarin, have revealed antitumor effects. Their mechanism of action is discussed together with that of other bioactive natural products, including angustifolin and moskachans. Altogether, R. angustifolia Pers. presents a rich phytochemical profile, fully consistent with the traditional use of the plant to treat cancer. This rue species, somewhat neglected, warrant further investigations as a medicinal plant and a source of inspiration for drug discovery and design.

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Section: Pharmacological Activities Of R Angustifolia ...mentioning

confidence: 99%

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Bailly

2023

Plants

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“…Apabila tidak ditangani dengan baik, penyakit yang disebabkan oleh jamur ini dapat menimbulkan masalah kesehatan yang serius terutama ketika spesies ini membentuk struktur biofilm. Berbagai ekstrak tanaman telah diteliti untuk melawan biofilm dari tanaman ini diantaranya adalah Acorus calamus (Subha dan Gananamani, 2009), Allium sativum (Shuford et al, 2005), Alpinia officinarum (Gong et al, 2011), Ruta angustifolia (Noer et al, 2021), dan lain-lain.…”

Section: Pendahuluanunclassified

Uji Daya Hambat Ekstrak Jahe Putih Terhadap Pertumbuhan Pseudomonas aeruginosa dan Candida albicans Secara in Vitro

Hadyprana

Noer

Supriyatin

2021

BSEJ

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Saat ini dunia sedang dilanda pandemi virus Corona (Covid-19) dan berbagai cara dianjurkan agar terhindar dari virus ini, salah satunya adalah dengan meningkatkan daya tahan tubuh baik secara tradisional maupun secara modern. Salah satu cara tradisional dalam mencegah mikroorganisme patogen adalah dengan mengkonsumsi rempah-rempah contohnya penggunaan jahe putih (Zingiber officinale var. Amarum) yang dapat mengganggu kesehatan adalah Pseudomonas aeruginosa dan Candida albicans. Tujuan dari penelitian ini adalah untuk mengetahui daya hambat ekstrak jahe putih terhadap pertumbuhan Pseudomonas aeruginosa dan Candida albicans sehingga dapat diketahui apakah ekstrak jahe putih terbukti efektif melawan mikroorganisme bakteri dan jamur. Metode yang digunakan dalam penelitian ini adalah metode disk diffusion untuk melihat keefektifan ekstrak jahe pada konsentrasi 20, 40, 60, 80 dan 100% terhadap pertumbuhan Pseudomonas aeruginosa dan Candida albicans. Hasil penelitian menunjukkan tiap konsentrasi ekstrak jahe putih yang ditentukan akan memberikan nilai daya hambat pertumbuhan Pseudomonas aeruginosa dan Candida albicans, yang artinya semakin tinggi konsentrasi maka semakin kuat daya hambat yang diberikan.

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Inhibition of Candida albicans hypha formation in biofilm formation by Ruta angustifolia extract

Cited by 2 publications

References 9 publications

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Ruta angustifolia Pers. (Narrow-Leaved Fringed Rue): Pharmacological Properties and Phytochemical Profile

Uji Daya Hambat Ekstrak Jahe Putih Terhadap Pertumbuhan Pseudomonas aeruginosa dan Candida albicans Secara in Vitro

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