Inhibition of Candida albicans biofilm formation and yeast-hyphal transition by 4-hydroxycordoin

Messier, Céline; Epifano, Francesco; Genovese, Salvatore; Grenier, Daniel

doi:10.1016/j.phymed.2011.01.013

Cited by 34 publications

(17 citation statements)

References 24 publications

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“…High-throughput screening performed by Heintz-Bushart and others revealed that compounds from methyl aryl-oxazoline carboxylate, dihydrobenzo [d]isoxazolone and thiazolo[4,5-e] benzoisoxazole families can effectively suppress hyphal production (Heintz-Buschart et al, 2013). Messier and coworkers found that natural isopentenyloxychalcone, 4-hydroxycordoin, inhibits hyphal formation of C. albicans at a concentration ranging from 50 to 200 μg/mL (Messier et al, 2011). Moreover, gymnemic acids…”

Section: Resultsmentioning

confidence: 99%

Emodin, a natural inhibitor of protein kinase CK2, suppresses growth, hyphal development, and biofilm formation of Candida albicans

Janeczko

Masłyk

Kubiński³

et al. 2017

Yeast

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Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a natural secondary plant product, originally isolated from the rhizomes of Rheum palmatum. Many reports show its diuretic, vasorelaxant, antibacterial, antiviral, anti-ulcerogenic, immunosuppressive, hepatoprotective, anti-inflammatory and anticancer potential. Emodin is a pleiotropic molecule capable of interacting with several major molecular targets, e.g. NF-κB, AKT/mTOR and STAT3. The compound can also act as an inhibitor of some protein kinases, with special affinity to protein kinase CK2. The aim of the presented report was to evaluate antifungal properties of emodin and its activity towards CK2 isolated from Candida cells. Our studies revealed that the compound suppressed growth of the cells of reference strains as well as clinical Candida strains, with minimal inhibitory concentration and minimal fungicidal concentration values between 12.5 and 200 μg/mL. Moreover, at a low concentration, the compound was able to effectively stop hyphal formation, thus showing a distinct antivirulent potential. Interestingly, we showed that emodin added to Candida culture inhibited the phosphorylation of many cellular proteins, presumably owing to the inhibition of protein kinase CK2. Notably, the enzyme isolated from the Candida cells was susceptible to emodin with IC of 2.8 μg/mL. Indeed, our computational modelling revealed that emodin was able to occupy the ATP-binding pocket of CK2. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Emodin, a natural inhibitor of protein kinase CK2, suppresses growth, hyphal development, and biofilm formation of Candida albicans

Janeczko

Masłyk

Kubiński³

et al. 2017

Yeast

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“…Biofilm formation was investigated by the method described by Messier et al (2011), with modifications. A yeast inoculum was added to Luria-Bertani (LB) broth (Oxoid) so that the initial yeast cell number was 10 5 c.f.u.…”

Section: Biofilm Formationmentioning

confidence: 99%

Deproteinated Potato Wastewater as a Sustainable Nitrogen Source in Trichosporon domesticum Yeast Lipids Biosynthesis—a Concept of Valorization of Wastewater from Starch Industry

Gientka

Aleksandrzak‐Piekarczyk

Bzducha-Wróbel

et al. 2019

Potato Res.

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This study determines the ability of an isolated Trichosporon domesticum yeast strain to accumulate intracellular lipids in media with deproteinated potato wastewater (DPW) containing various carbon sources. The yeast strain was isolated from kefir and identified by internal transcribed spacer (ITS) region sequence analysis. The sequence was deposited in GenBank under accession number MH094668, and the strain was deposited in Polish Collection of Microorganisms as T. domesticum PCM 2960. DPW is an inexpensive and valuable source of nitrogen, potassium, phosphorus, and other elements in yeast cultures. DPW supplemented with glucose medium was most effective at stimulating lipid biosynthesis by T. domesticum PCM 2960 and bioreactor incubation resulted in a final lipid yield of 4.8 g L −1. The lipids of the T. domesticum PCM 2960 biomass were characterized by high contents of linoleic acid (Δ9,12 C18:2), oleic acid (Δ9 C18:1), palmitic acid (C16:0), and α-linolenic acid (Δ9,12,15 C18:3). Theoretical calculations for biodiesel properties showed that the methylated esters of lipids from T. domesticum PCM 2960 biomass cannot be used as a biodiesel in diesel engines. Additionally, the ability to produce biofilm as one criterion for pathogenicity was tested. The ability for biofilm formation by the isolated strain was low. This study provides a promising solution for the more economical production of microbial lipids with DPW.

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“…Denture stomatitis is a common form of oral Candidiasis presented among complete or partial denture wearers, and it is defined as an inflammation of the palatal mucosa in contact with the denture 1710…”

Section: Introductionmentioning

confidence: 99%

Fiber‐reinforced nanopigmented poly(methyl methacrylate) as improved denture base

Moreno-Maldonado

Acosta-Torres

Barceló-Santana

et al. 2012

J of Applied Polymer Sci

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Nanopigmented and fiber‐reinforced poly (methyl methacrylate) (PMMA) were synthesized for denture bases, by incorporating E‐glass fibers, flock fibers, or polyethylene fibers into the PMMA powder formulation to improve the flexural behavior and porosity; decreasing the Candida albicans adherence and being noncytotoxic. The commercial acrylic resin, Lucitone 199 was used as a control group. Scanning electron microscopy analysis was performed to the PMMA particles and the reinforcing fibers. Flexural strength increased by adding E‐glass fibers in the PMMA powder as compared to flock and polyethylene fibers. The reinforced PMMA with flock fibers showed the lower porosity even smaller than Lucitone 199. The synthesized PMMA and the fiber reinforced nanopigmented PMMA groups reduced significantly the C. albicans adherence when compared to the commercial acrylic resin. All the tested groups were found to be nontoxic materials after being in contact with mouse fibroblast culture during 24 h, showing that these novel nanostructured composites are suitable for producing adequate and nontoxic reinforced materials with antimicrobial properties for dentistry applications. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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Inhibition of Candida albicans biofilm formation and yeast-hyphal transition by 4-hydroxycordoin

Cited by 34 publications

References 24 publications

Emodin, a natural inhibitor of protein kinase CK2, suppresses growth, hyphal development, and biofilm formation of Candida albicans

Emodin, a natural inhibitor of protein kinase CK2, suppresses growth, hyphal development, and biofilm formation of Candida albicans

Deproteinated Potato Wastewater as a Sustainable Nitrogen Source in Trichosporon domesticum Yeast Lipids Biosynthesis—a Concept of Valorization of Wastewater from Starch Industry

Fiber‐reinforced nanopigmented poly(methyl methacrylate) as improved denture base

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