Inhibition of biological activity of cholecalciferol (vitamin D3) by o,p'-DDT or p,p'-DDT in rachitic cockerel

Nowicki, Henry G.; Wong, Richard G.; Myrtle, James F.; Norman, Anthony W.

doi:10.1021/jf60180a058

Cited by 15 publications

(3 citation statements)

References 17 publications

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“…Thinning egg shells is closely related to calcium metabolism which is largely regulated by two steroids, estradiol and vitamin D [22]. Although it has long been suspected that DDT disturbs the metabolism of vitamin D, early experimental studies in 1960s or 70s failed to show that DDT disturb vitamin D metabolism [23], [24], [25].…”

Section: Discussionmentioning

confidence: 99%

Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population

et al. 2012

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BackgroundRecently low dose organochlorine (OC) pesticides have been strongly linked to various chronic diseases including diabetes and cardiovascular diseases. Both field and animal studies have suggested a possibility that persistent lipophilic chemicals like OC pesticides can cause vitamin D deficiency, but there have been no human studies of exposure to any chemical as a possible cause of vitamin D deficiency. This study was performed to examine if serum concentrations of OC pesticides were associated with serum concentrations of 25-hydroxyvitamin D (25(OH)D) in the U.S. general population.Methodology/Principal FindingsCross-sectional associations of serum OC pesticides with serum 25(OH)D were investigated in 1,275 subjects aged ≥20 in the National Health and Nutrition Examination Survey(NHANES), 2003–2004. We selected 7 OC pesticides detectable in ≥80% of participants. Among the 7 OC pesticides, p,p′-DDT (β = −0.022, P<0.01), p,p′-DDE (β = −0.018, P = 0.04), and β-hexachlorocyclohexane (β = −0.022, P = 0.02) showed significant inverse associations with serum 25(OH)D levels. When study subjects were stratified by age, race, and the presence of various chronic diseases, p,p′-DDT showed consistent inverse associations in all subgroups, although stronger associations tended to be observed among subjects with old age, white race, or chronic diseases.Conclusion/SignificanceThe current study suggests that the background exposure to some OC pesticides leads to vitamin D deficiency in human. Considering the importance of vitamin D deficiency in the development of chronic diseases, chemical exposure as a possible cause of vitamin D deficiency should be evaluated in prospective and experimental studies.

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Section: Discussionmentioning

confidence: 99%

Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population

et al. 2012

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“…Nevertheless, it should be pointed out that excretion was the route that was most affected in quantitative terms. Peakall (1969) and Nowicki et al (1972) have suggested that the action of certain chlorinated hydrocarbons, and specifically that of DDT, is not associated with an effect on gastrointestinal absorption of Ca, but rather, exerted through the Ca that is already absorbed, due to anomalies in its storage and mobilization. Since in birds the urine and feces are excreted together, it is impossible at this time for us to determine whether the forementioned effects occur at a digestive level because the intestinal absorption increases, or on the other hand, it is the result of a metabolic phenomenon which would lead to a decreased urinary excretion, or perhaps, a combined action of both effects.…”

Section: Methodsmentioning

confidence: 99%

Dieldrin, Ca and P Balance, and Characteristics of the Egg in the Quail (Coturnix coturnix japonica)

1978

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A study was made of the Ca and P balance, Ca and P content in the femur, physical characteristics of the egg, mineral structure of the shell, and the number of eggs in quails treated with dieldrin (20 mg/kg of diet) for 48 days. The diet contained 3.24% Ca and 0.72% P. The Ca and P balance, the bone contents of Ca and P and the calcemia in the males were not changed by the pesticide. In the females, the pesticide decreased the amount of excreted Ca and Ca in the egg, for which reason the coefficient of nutritive utilization (CNU), the coefficient of corporal retention (CCR), and the Ca level in the femur were greater in treated laying quails. The calcemia remained stable, and the balance of P was not significantly modified by the dieldrin. The study of weight, size, and strength of the egg did not reveal any influence of the dieldrin, and egg production fluctuated throughout the test period.

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“…Laboratory experiments have shown that dichlorodiphenyl-trichloroethane (DDT) interferes with the function of cholecalciferol in NSH cockerels (Nowicki et al, 1972a(Nowicki et al, , 1972b. OCs were detected in bile, feces, feathers and blood of NSH crows and in one blood and one feather sample of control crows.…”

Section: Organochlorinesmentioning

confidence: 99%

Environmental factors associated with nutritional secondary hyperparathyroidism in wild birds

Tangredi¹

2007

Avian & Poul. Biolog. Rev.

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Six published case reports of nutritional secondary hyperparathyroidism are described occurring in different species of juvenile wild birds worldwide. Gross skeletal deformities are characterised by fractures and curvature of the long bones and beak resulting from an altered calciumyphosphorus ratio in the blood. The histopathologic diagnosis is osteodystrophia fibrosa and parathyroid gland hyperplasia. Deficiency of vitamin D is implicated in the two instances in which this was measured. Environmental factors include: decreased biodiversity of food sources, surface water pollution, seasonal conditions affecting food and exposure to UV light, and sub-lethal exposure to xenobiotics. Evidence is presented on the possible role of xenobiotics in the pathogenesis.

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Inhibition of biological activity of cholecalciferol (vitamin D3) by o,p'-DDT or p,p'-DDT in rachitic cockerel

Cited by 15 publications

References 17 publications

Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population

Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population

Dieldrin, Ca and P Balance, and Characteristics of the Egg in the Quail (Coturnix coturnix japonica)

Environmental factors associated with nutritional secondary hyperparathyroidism in wild birds

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