Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population

Yang, Jung–Min; Lee, Yu Mi; Bae, Sang Geun; Jacobs, David R.; Lee, Dong Hoon

doi:10.1371/journal.pone.0030093

Cited by 29 publications

(13 citation statements)

References 26 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…) including humans (Yang et al . ), indicating the possibility that this mechanism affects VD status in vivo as well. One of the toxic endpoints of PAH‐induced disturbance of VD that may be of importance for farmed fish is disturbance of bone formation.…”

Section: Pah Interactions With Vitaminsmentioning

confidence: 99%

Polyaromatic hydrocarbons in aquafeeds, source, effects and potential implications for vitamin status of farmed fish species: a review

Berntssen¹,

Ørnsrud²,

Hamre³

et al. 2015

Aquacult Nutr

View full text Add to dashboard Cite

Access to marine feed ingredients is considered a limiting factor for the rapidly growing aquaculture industry. With increasing inclusion of vegetable feed ingredients in aquafeeds, new challenges have arisen. Substituting marine oils and meals with vegetable ingredients has decreased the level of persistent organic pollutants (POPs) in marine farmed fish such as Atlantic salmon. Consequently, this shift in feed ingredients has led to increased levels of polyaromatic hydrocarbons (PAHs) in aquafeeds. Several of the PAHs listed are on EFSAs and EPAs list of priority substances. Not only are the carcinogenic and genotoxic properties of PAHs of concern, but also their ability to interact with and disrupt metabolic pathways such as vitamin metabolism and signalling. The interactions, and the potential depletion of vitamin stores that follows, are of particular interest as marine ingredients are naturally rich in micronutrients such as vitamins A and D. This study has summarized the current knowledge on the effect of PAHs commonly found in vegetable feed ingredients on vitamin metabolism/signalling and their possible implications in fish.

show abstract

Section: Pah Interactions With Vitaminsmentioning

confidence: 99%

Polyaromatic hydrocarbons in aquafeeds, source, effects and potential implications for vitamin status of farmed fish species: a review

Berntssen¹,

Ørnsrud²,

Hamre³

et al. 2015

Aquacult Nutr

View full text Add to dashboard Cite

show abstract

“…Potential neurotoxic effects of organochlorine compounds were reported on early psychomotor development even at low doses (Forns et al ., 2012). A positive correlation was observed of exposure to some OC pesticides and vitamin D deficiency in humans (Yang et al ., 2012). Early exposure to certain environmental chemicals, especially organochlorine compounds, with endocrine-disruption activity were reported to interfere with neonatal thyroid hormone status (Freire et al ., 2011).…”

Section: Effect In Humansmentioning

confidence: 99%

Review Article. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment

Ravindran

Megha

Puthur

2016

Interdisciplinary Toxicology

866

359

View full text Add to dashboard Cite

Organochlorine (OC) pesticides are synthetic pesticides widely used all over the world. They belong to the group of chlorinated hydrocarbon derivatives, which have vast application in the chemical industry and in agriculture. These compounds are known for their high toxicity, slow degradation and bioaccumulation. Even though many of the compounds which belong to OC were banned in developed countries, the use of these agents has been rising. This concerns particularly abuse of these chemicals which is in practice across the continents. Though pesticides have been developed with the concept of target organism toxicity, often non-target species are affected badly by their application. The purpose of this review is to list the major classes of pesticides, to understand organochlorine pesticides based on their activity and persistence, and also to understand their biochemical toxicity.

show abstract

“…Moreover, a non-monotonic inverse association between the sum of predominant PCB (PCB 180, 153, and 138) and 25(OH)D3 concentrations was demonstrated [128]. The first human study linking the organochlorine (OC) pesticides and serum 25(OH)D was performed by Yang et al [129]. In 1275 adults it was found that concentrations of p,p -DDT, p,p -DDE, and β-esaclorocicloesano were significantly and negatively related to serum 25(OH)D levels.…”

Section: Vitamin Dmentioning

confidence: 99%

Endocrine Disrupting Chemicals and Type 1 Diabetes

Predieri

Bruzzi

Bigi

et al. 2020

IJMS

View full text Add to dashboard Cite

Type 1 diabetes (T1D) is the most common chronic metabolic disease in children and adolescents. The etiology of T1D is not fully understood but it seems multifactorial. The genetic background determines the predisposition to develop T1D, while the autoimmune process against β-cells seems to be also determined by environmental triggers, such as endocrine disrupting chemicals (EDCs). Environmental EDCs may act throughout different temporal windows as single chemical agent or as chemical mixtures. They could affect the development and the function of the immune system or of the β-cells function, promoting autoimmunity and increasing the susceptibility to autoimmune attack. Human studies evaluating the potential role of exposure to EDCs on the pathogenesis of T1D are few and demonstrated contradictory results. The aim of this narrative review is to summarize experimental and epidemiological studies on the potential role of exposure to EDCs in the development of T1D. We highlight what we know by animals about EDCs’ effects on mechanisms leading to T1D development and progression. Studies evaluating the EDC levels in patients with T1D were also reported. Moreover, we discussed why further studies are needed and how they should be designed to better understand the causal mechanisms and the next prevention interventions.

show abstract

Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population

Cited by 29 publications

References 26 publications

Polyaromatic hydrocarbons in aquafeeds, source, effects and potential implications for vitamin status of farmed fish species: a review

Polyaromatic hydrocarbons in aquafeeds, source, effects and potential implications for vitamin status of farmed fish species: a review

Review Article. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment

Endocrine Disrupting Chemicals and Type 1 Diabetes

Contact Info

Product

Resources

About