Inhibition of Benzoyl Peroxide–Induced Cutaneous Oxidative Stress, Toxicity, and Ear Edema in Mice byNardostachys jatamansi.

Abstract

Recent years have shown considerable efforts to identify new chemopreventive agents that could be of clinical value. In the current study, modulatory effect of Nardostachys jatamansi (Jones) DC on benzoyl peroxide-induced oxidative stress, toxicity, and ear edema is investigated. Pretreatment with jatamansi at doses of 2.5 and 5 mg=kg body weight in acetone prior to the application of benzoyl peroxide (20 mg=animal per 0.2 ml acetone) resulted in significant inhibition of benzoyl peroxide-induced cutaneous oxidative stress, toxicity, and ear edema in a dose-dependent manner. The cutaneous microsomal membrane lipid peroxidation and xanthine oxidase activities were significantly reduced (p < 0.05). Moreover, the depleted levels of phase II metabolizing enzymes and glutathione were recovered significantly (p < 0.05). Our findings suggest that N. jatamansi is an effective chemopreventive agent in mouse skin with potential of ameliorating benzoyl peroxide-induced cutaneous oxidative stress, toxicity, and ear edema.

Oxidative stress mediates rapid compensatory growth and its costs

“…BPO exposure in mice has been demonstrated to deplete antioxidant defence and increase lipid peroxidation (e.g. Ali, Dua, Siddiqui, Sultana, & Rafiullah, 2005; Sharma & Sultana, 2004). To determine a suitable concentration of the free radical initiator BPO (Slaga et al., 1981), we first ran a range finding experiment with five concentrations (control, 1, 2, 5, 10 and 20 mg/L).…”

“…Although the selected BPO concentration was in the same order of magnitude as those used in other studies (e.g. Ali et al., 2005; Sharma & Sultana, 2004) and not lethal during a 4‐week exposure during the range finding test, the exposure duration during the actual experiment was much longer (up to 37 days longer) and considerable mortality (up to 50%) due to BPO exposure was observed. As a consequence, it was not possible to accurately assess which of the BPO‐induced effects were really caused by oxidative stress and to what amount also other toxic effects played a role.…”

Narjatamanins A and B, a pair of novel epimers possessing a 2,3-seco-iridoid skeleton with an unusual 1,10-oxygen bridge from Nardostachys jatamansi and evaluation of their effects on worm paralysis in AD C. elegans

“…3 Several biological effects of the extracts from this species were reported, such as stress remedies, nervous headaches, epilepsy, intestinal colic, improving learning and memory and liver protection. [4][5][6][7] Besides, recent studies have showed chemical constituents of N. jatamansi possess positive anti-Alzheimer's disease activity. 8,9 To the best of our knowledge, previous phytochemical investigations on N. jatamansi led to the isolation of iridoids, sesquiterpenoids, and lignans.…”

Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats

“…27 An acetone extract of N. jatamansi has shown significant inhibition of benzoyl peroxide-induced cutaneous oxidative stress, toxicity, and ear edema in mice. 28 It has also been reported to possess protective activity in 6-hydroxydopamine-induced, parkinsonism in rats. 29 These pharmacological properties of N. jatamansi prompted us to evaluate its efficacy in haloperidol-induced parkinsonism.…”